Protective Effect of Curcumin against Sodium Salicylate-Induced Oxidative Kidney Damage, Nuclear Factor-Kappa Dysregulation, and Apoptotic Consequences in Rats

Abstract

This study examined the effect of sodium salicylates (SS), alone and in combination with curcumin (CUR), on kidney function and architecture in rats. Five rat groups were given 1 mL physiological saline/rat orally, 1 mL olive oil/rat orally, 50 mg CUR/kg bwt orally, 300 mg SS/kg bwt intraperitoneally, or CUR+SS for 15 days. The hematological indices, serum protein profile, serum electrolytes balance, oxidative stress, and lipid peroxidation of kidney tissues were assessed. The histopathological examination and immune expression of Caspase-3 and nuclear factor kappa (NF-κB) were conducted. The findings showed that SS injection induced nephrotoxic activity, including increased serum urea, creatinine, and uric acid levels. It also caused apparent pathological alterations with increased Caspase-3 and NF-κB immuno-expression. In addition, thrombocytopenia, leukocytosis, neutrophilia, hyponatremia, hypochloremia, hypocalcemia, and hypomagnesemia but not hyperkalemia and hyperphosphatemia were evident in SS-injected rats. Moreover, SS exposure increased serum α1 globulin, renal tissue malondialdehyde, and Caspase-3 levels but superoxide dismutase, glutathione peroxidase, and Bcl-2 levels declined. Meanwhile, CUR significantly counteracted the SS harmful impacts on kidneys but SS+CUR co-administration induced an anemic condition. Overall, CUR has an evident protective role against SS-induced renal damage, but the disturbed hematological alterations should be carefully taken into consideration in their combined use.

Toll-like receptors and nuclear factor kappa B signaling pathway involvement in hepatorenal oxidative damage induced by some food preservatives in rats

“…The liver is the main site of xenobiotic metabolism and is consequently highly susceptible to its harmful impacts 27 , 51 . In the current study, a marked impaired liver function was detected in the rats orally given BHA, PS, SB, BA, and CP for 90 days, which reflected in a significant increase in serum AST and ALT levels than control ones.…”

“…The liver is responsible for a major portion of xenobiotic metabolism 26 . The kidney tubule cell produces proinflammatory cytokines that directly respond to infections or toxins 27 . These cells function as proinflammatory cells, or immune system responders are crucial in developing renal dysfunction 28 .…”

Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats

“…As a result, CCM showed beneficial roles in a variety of health problems such as autoimmune diseases (Aggarwal and Harikumar 2009 ), cancer (Momtazi and Sahebkar 2016 ), diabetes mellitus (Pivari et al 2019 ), and liver disease (Abd-Elhakim et al 2021c ; Jalali et al 2020 ). Also, CCM has strong anti-inflammatory (Aggarwal and Harikumar 2009 ), antiapoptotic (Abd-Elhakim et al 2021b ), antigenotoxic (Saber et al 2019 ), and immunostimulant (Mollazadeh et al 2019 ) activities. Besides, CCM has shown important protective effects against widespread ototoxic substances and hearing disorders (Bucak et al 2015 ; Soyalıç et al 2017 ; Soyalıç et al 2016 ).…”

The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats

“…Currently, a global interest has been directed toward using medicinal herb products to reduce adverse effects associated with drug use (Abd-Elhakim et al 2022 , 2021a , b ; Abd El-Rahman et al 2020 ). The current study revealed that PTL oral dosing for 7 days resulted in a significant decrease in weight gain with a significant increase in hepatosomatic index.…”