Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats

Abd‐Elhakim, Yasmina M.; Abdel-Motal, Sabry M.; Malhat, Seham M.; Mostafa, Hatem; Ibrahim, Walied M.; Beheiry, Rasha R.; Moselhy, Attia A.A.; Said, Enas N.

doi:10.1007/s11356-022-21932-1

Cited by 9 publications

(1 citation statement)

References 84 publications

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“…Furthermore, it did not interfere with the anticancer effect of CIS. This study supplements the evidence that CUR/GOQDs can effectively protect the hearing of guinea pigs after administration ( Abd-Elhakim et al, 2022 ). It is well tolerated and does not affect hearing itself, even if the daily dose concentration is several weeks higher than the concentration used for ear protection.…”

Section: Discussionsupporting

confidence: 84%

Curcumin-loaded graphene oxide quantum dots enhance otoprotective effects via blocking cuproptosis

Zhang

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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Graphical AbstractMechanisms by which exposure to cisplatin disrupts the inner ear system are not yet known. Here, we show that cisplatin exposure is associated with dysregulation of oxidative stress in the inner ear of the rodent. Furthermore, we found that, unlike controls, the response parameters of auditory cells of rats exposed to cisplatin were related to an imbalance in copper metabolism. These data suggest that curcumin related changes in the inner ear are depend on their effects on the mechanism of balance of the copper metabolism and that exposure to cisplatin can disrupt the plastic copper metabolism mechanisms needed to restore normal processing in peripheral auditory cells after hearing loss.

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Section: Discussionsupporting

confidence: 84%

Curcumin-loaded graphene oxide quantum dots enhance otoprotective effects via blocking cuproptosis

Zhang

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats

Fadil

Behairy

Ebraheim

et al. 2023

Environ Sci Pollut Res

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This study investigated the possible protective role of mulberry leaf (MLE) and olive leaf (OLE) ethanolic extracts against paracetamol (PTL)–induced liver injury in rats compared to silymarin as a reference drug. Initially, MLE and OLE were characterized using gas chromatography–mass spectrometry (GC/MS). Then, forty male Sprague Dawley rats were divided into five groups: the negative control group orally received distilled water for 35 days, the PTL-treated group (PTG) received 500 mg PTL/kg b. wt. for 7 days, the MLE-treated group (MLTG) received 400 mg MLE/kg b. wt., the OLE-treated group (OLTG) received 400 mg OLE/kg b. wt., and the silymarin-treated group (STG) received 100 mg silymarin/kg b. wt. The last three groups received the treatment for 28 days, then PTL for 7 days. The GC–MS characterization revealed that MLE comprised 19 constituents dominated by ethyl linoleate, phytol, hexadecanoic acid, ethyl ester, and squalene. Moreover, OLE comprised 30 components, and the major components were 11-eicosenoic acid, oleic acid, phytol, and à-tetralone. MLE and OLE significantly corrected the PTL-induced normocytic normochromic anemia, leukocytosis, hypercholesterolemia, and hypoproteinemia. Moreover, the MLE and OLE pretreatment considerably suppressed the PTL-induced increment in serum levels of hepatic enzymes, including alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase. Furthermore, the PTL-induced depletion in antioxidant enzymes, including glutathione peroxidase, superoxide dismutase, and catalase, and the rise in hepatic malondialdehyde content were significantly reversed by the MLE and OLE pretreatment. Besides, MLE and OLE pretreatment significantly protected the hepatic tissue against PTL-induced DNA damage, pathological perturbations, and increased caspase 3 and CYP2E1 immunoexpression. Of note, OLTG showed better enhancement of most indices rather than MLTG. Conclusively, these findings imply that OLE, with its antioxidant and antiapoptotic capabilities, is superior to MLE in protecting against PTL-induced liver injury.

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Development of Chinese herbal medicine for sensorineural hearing loss

Wu,

Zhang,

Liu

et al. 2024

Acta Pharmaceutica Sinica B

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Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats

Cited by 9 publications

References 84 publications

Curcumin-loaded graphene oxide quantum dots enhance otoprotective effects via blocking cuproptosis

Curcumin-loaded graphene oxide quantum dots enhance otoprotective effects via blocking cuproptosis

The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats

Development of Chinese herbal medicine for sensorineural hearing loss

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