Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis

Ramadan, Gamal; Elmenshawy, Omar M.

doi:10.1111/1756-185x.12054

Cited by 52 publications

(35 citation statements)

References 39 publications

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“…It inhibits Cyclooxygenase-2 and 5-Lipoxygenase pathways. Ginger induces T-helper-2, and anti-inflammatory cytokines such as IL-4 and IL-10 production, 33,34 increases glutathione level, and activity of the antioxidant enzyme like superoxide dismutase, 35 inhibits the release of substance P (mediator of inflammation and pain), 36 and decreases TNFα, IL1β, IL6, IL2, and prostaglandins levels. One Study shows Ginger is more effective than indomethacin in reducing the pain associated with inflammation and oxidative stress.…”

Section: Ginger and Rheumatic Disordersmentioning

confidence: 99%

Ginger and its Effects on Inflammatory Diseases

Aryaeian¹,

Tavakkoli²

2015

Adv Food Technol Nutr Sci Open J

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Today, Ginger is used as a spice all around the world. In the past, Ginger was consumed for the treatment of various diseases, including osteo-arthritis, neurological diseases, vomiting, asthma, and so on. It seems that Ginger can reduce inflammation in those diseases. We searched the following keywords in PubMed, Google scholar, and Scopus database until 2015: inflammation and Ginger, Ginger and diseases. Clinical trials, animal studies, and human studies were included in the results of this search. Ginger extract with the antioxidant and anti-inflammatory ingredients such as 6 Gingerols, 6-Shogoals, Zhingerol, etc can reduce inflammatory mediators such as inflammatory cytokines and chemokines due to their effects on NF-κB activation, cyclooxygenase 2 reduction and serotonin receptors inhibition. It increases reducing antioxidant enzymes so it can be useful in inflammatory diseases improvement and their complications prevention. In conclusion, Ginger can help in the treatment of inflammatory chronic diseases such as Fatty Liver, Asthma, Cancer and Arthritis through anti-inflammatory, immunoregulatory and antioxidative mechanisms.

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Section: Ginger and Rheumatic Disordersmentioning

confidence: 99%

Ginger and its Effects on Inflammatory Diseases

Aryaeian¹,

Tavakkoli²

2015

Adv Food Technol Nutr Sci Open J

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“…1 The most prevalent forms of these articular diseases being osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is an auto immune disorder caused due to trigger of pro-inflammatory cytokines (eg, TNF-α and IL-1β) while osteoarthritis is a degenerative joint disease characterized by the progressive breakdown of articular cartilage.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Naz¹,

Ahmad²

2015

IJN

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The present work investigated the topical delivery potential of nanoemulsion gel loaded with curcumin (CR). CR nanoemulsion (CR-NE) was prepared by spontaneous emulsification method using oil (Labrafac PG/glyceryl triacetate), surfactant:cosurfactant (S mix ) (tween 80/polyethylene glycol [PEG] 400) and water. The pseudo-ternary phase diagrams were constructed and thermodynamic stability testing was performed. Droplet size and zeta potential were evaluated using photon correlation spectroscopy and transmission electron spectroscopy. Six formulations selected with an average droplet size ≤70±2.72 nm showed a fourfold increase in skin permeation as compared to crude CR solution in oil. The formulation CR-NE4 having a flux of 117.04±2.32 µg/cm 2 /h and with maximum retention (42.87%) was selected, characterized (droplet size =41.13±3.34 nm and zeta potential =−33.1±1.45 mV), and incorporated into gel using carbopol-980 (1% w/v). Skin dynamics analyzed by confocal laser scanning microscopy showed maximum deposition of CR up to a depth of 86.98 µm and was in concordance with differential scanning calorimetry and Fourier transform infrared spectroscopy studies that confirmed lipid bilayer disruption, enhancing permeation. A 28-day anti-arthritic evaluation (body weight, paw edema, tibiotarsal joint thickness, TNF-α and IL-1β levels, and histopathology) on Freund’s complete adjuvant induced arthritic rat model after topical application of CR-NE gel in Wistar rats demonstrated substantial reversal of arthritic symptoms. Thus, CR-NE gel possesses potential for therapeutic effects locally in inflammatory arthritic disorders with improved topical bioavailability.

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“…Ginger extract or its pungent constituents, including gingerol and shogaol, are also reported to have antiinflammatory activities in experimental animal models (Lee et al, 2012). The anti-inflammatory effects of ginger and its components have been reported in patients with type 2 diabetes (Priya Rani et al, 2011), osteoarthritis (Drozdov et al, 2012), rheumatoid arthritis (Ramadan and El-Menshawy, 2013), acute respiratory distress syndrome (Vahdat Shariatpanahi et al, 2013), primary dysmenorrheal (Rahnama et al, 2012) and also in experimental models of airway inflammation (Kuo et al, 2011), ulcerative colitis (El-Abhar et al, 2008, neuroinflammation (Ha et al, 2012) and gastric ulcers (Wang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

Jafarzadeh

Mohammadi-Kordkhayli

Ahangar-Parvin

et al. 2014

Journal of Neuroimmunology

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Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis

Abstract: Ginger-turmeric rhizomes mixture may be effective against RA severity and complications as shown in an AIA rat model.

Cited by 52 publications

References 39 publications

Ginger and its Effects on Inflammatory Diseases

Ginger and its Effects on Inflammatory Diseases

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

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