Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

Jafarzadeh, Abdollah; Mohammadi-Kordkhayli, M.; Ahangar-Parvin, Rayhaneh; Azizi, V.; Khoramdelazad, Hossein; Shamsizadeh, Ali; Ayoobi, A.; Nemati, Maryam; Hassan, Zuhair Muhammad; Moazeni, S M; Khaksari, Mohammad

doi:10.1016/j.jneuroim.2014.08.614

Cited by 42 publications

(41 citation statements)

References 72 publications

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“…A novel luteolin analog, tetramethoxyluteolin, is more potent that luteolin (Weng et al, 2014b), making it an attractive molecule for drug development especially since it is also less metabolized (Walle, 2007). Black ginger is rich in methoxyluteolin (Wei et al, 2014) and it is interesting that a ginger extract was recently reported to reduce the clinical symptoms of experimental immune encephalomyelitis and IL-33 expression in the spinal cord of the mice (Jafarzadeh et al, 2014). Recent reviews have discussed the possible use of flavonoids in the treatment of neurodegenerative diseases (Jäger and Saaby, 2011;Jones et al, 2012;Solanki et al, 2015).…”

Section: Il-33 In Autoimmune and Inflammatory Disordersmentioning

confidence: 99%

Targeting IL-33 in Autoimmunity and Inflammation

Theoharides

Petra

Taracanova

et al. 2015

J Pharmacol Exp Ther

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Section: Il-33 In Autoimmune and Inflammatory Disordersmentioning

confidence: 99%

Targeting IL-33 in Autoimmunity and Inflammation

Theoharides

Petra

Taracanova

et al. 2015

J Pharmacol Exp Ther

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“…Ginger, of which 6‐GIN is a major active compound, has been used as an immune therapeutic drug for centuries in Asia . For example, Jafarzadeh et al . reported that ginger extracts alleviate the clinical course of EAE by influencing the IL‐27 and IL‐33 expression.…”

Section: Discussionmentioning

confidence: 99%

Treatment with 6‐Gingerol Regulates Dendritic Cell Activity and Ameliorates the Severity of Experimental Autoimmune Encephalomyelitis

Han

et al. 2019

Molecular Nutrition Food Res

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Scope: Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder, with increasing incidence worldwide but unknown etiology. 6-Gingerol (6-GIN), a major dietary compound found in ginger rhizome, has immunomodulatory activity. However, its role in autoimmune diseases, as well as the underlying mechanisms, are unclear. In this study, it is evaluated if 6-GIN can effectively ameliorate the clinical disease severity of experimental autoimmune encephalomyelitis, an animal model of MS. Methods and results: Clinical scores of experimental autoimmune encephalomyelitis (EAE) mice are recorded daily. Inflammation of periphery and neuroinflammation of EAE mice are determined by flow cytometry analysis, ELISA, and histopathological analysis, and results show that 6-GIN significantly inhibits inflammatory cell infiltration from the periphery into the central nervous system and reduces neuroinflammation and demyelination. Flow cytometry analysis, ELISA, and quantitative PCR show that 6-GIN could suppress lipolysaccharide-induced dendritic cell (DC) activation and induce the tolerogenic DCs. Immunoblot analysis reveals that the phosphorylation of nuclear factor-κB and mitogen-activated protein kinase, two critical regulators of inflammatory signaling, are significantly inhibited in 6-GIN-treated DCs. Conclusion: The results of this study demonstrate that 6-GIN has significant potential as a novel anti-inflammatory agent for the treatment of autoimmune diseases such as MS via direct modulatory effects on DCs.

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“…system seems to alleviate the symptoms of EAE (ref. 49 ). Both c-Maf and AHR seems to be partially regulated by PTIP -under no PTIP influence the production of IL-22 rises while that of IL-17 decreases 50 .…”

Section: C-mafmentioning

confidence: 99%

The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

Zarobkiewicz

Kowalska

Sławiński

et al. 2019

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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The aim of this paper was to summarise knowledge of IL-22 involvement in multiple sclerosis (MS) and the possible link between IL-22 and two transcription factors-AHR and c-Maf. The conclusion is that despite numerous studies, the exact role of IL-22 in the pathogenesis of MS is still unknown. The expression and function of c-Maf in MS have not been studied. It seems that the functions of c-Maf and AHR are at least partly connected with IL-22, as both directly or indirectly influence the regulation of IL-22 expression. This possible connection has never been studied in MS.

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Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

Cited by 42 publications

References 72 publications

Targeting IL-33 in Autoimmunity and Inflammation

Targeting IL-33 in Autoimmunity and Inflammation

Treatment with 6‐Gingerol Regulates Dendritic Cell Activity and Ameliorates the Severity of Experimental Autoimmune Encephalomyelitis

The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

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