Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats

Korani, Mehrdad Shahrani; Farbood, Yaghoob; Sarkaki, Alireza; Moghaddam, Hadi Fathi; Mansouri, Mohammad Taghi

doi:10.1016/j.ejphar.2014.03.044

Cited by 67 publications

(31 citation statements)

References 46 publications

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“…These results suggested that GA did not disturb memory. This is in coincidence with the data of Korani et al (2014) who found that GA ameliorated the spatial memory deficit in a model of vascular dementia (15). Mansouri et al (2013) found that GA prevented the cognitive deficit in a model of Alzheimer's disease (16).…”

Section: Discussionsupporting

confidence: 86%

Effects of gallic acid on exploratory behavior and locomotor activity in rats

Georgieva¹,

Belcheva²,

Tashev³

et al. 2015

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PURPOSE: The present study investigated the effects of GA on exploratory behavior and locomotor activity in male Wistar rats. METHODS: GA (20 mg/kg) or saline were administrated orally to different groups of rats for 7, 14, 21 and 30 days. At the end of each experimental period, the changes in rat behavior were recorded in an Opto Varimex apparatus. The number of horizontal and vertical movements recorded every minute served as a measure of exploratory activity and habituation. The total number of movements was used as a measure of locomotor activity. RESULTS: It was found that after 7 days of treatment, GA did not significantly affect exploratory behavior and locomotor activity of rats compared to the saline-treated controls. After the 14 day treatment period, GA did not significantly affect horizontal activity but reduced the number of vertical movements. After 21 and 30 days, GA significantly reduced both horizontal and vertical movements of rats compared to the controls. At all testing periods, GA did not disturb habituation which is considered as an elementary form of learning. CONCLUSION: The present study suggested that GA applied subchronically to rats has a sedative effect and does not disturb the memory and learning processes.

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Section: Discussionsupporting

confidence: 86%

Effects of gallic acid on exploratory behavior and locomotor activity in rats

Georgieva¹,

Belcheva²,

Tashev³

et al. 2015

TJS

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“…GA an endogenous plant phenol is known to have antioxidant, anti-cancer, anti-inflammatory, neuroprotective, and free radical scavenging activity. [ 12 32 33 34 35 36 37 38 ]…”

Section: Discussionmentioning

confidence: 99%

Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical

et al. 2016

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Background:Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti-inflammatory, anti-cancer, and anti-fungal properties. The aim of this study was to assess the protective effect of GA on cyclophosphamide (CPA)-induced hepatotoxicity in male Wistar rats.Methods:Sixty rats were grouped into six groups of 10 rats per group. Group 1 received distilled water. Group 2 received CPA at 200 mg/kg single dose intraperitoneally on day 1. Groups 3 and 4 received a single dose of CPA (200 mg/kg) intraperitoneally on day 1 and then were treated with GA at 60 and 120 mg/kg body weight for 14 days, respectively. Rats in Groups 5 and 6 only received GA at 60 and 120 mg/kg body weight for 14 days, respectively. GA was administered orally.Results:CPA induced hepatic damage as indicated by significant elevation (P < 0.05) in aspartate aminotransferase, organ weight, and evidence by the histological study. CPA also induced hepatic oxidative stress as indicated by significant elevation (P < 0.05) in malondialdehyde content, hydrogen peroxide (H2O2) generation, nitrite level, and the level of glutathione (GSH) peroxidase crashed in the CPA-treated group. GA enhanced the antioxidant defense system as indicated by significant elevation (P < 0.05) in GSH level, catalase activity, and GSH-S-transferase activity.Conclusions:Taken together, the result of this present study shows that GA has a protective effect on CPA-induced hepatotoxicity.

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“…Therefore, it significantly enhanced the cerebral antioxidant defense against cognitive deficits. 65 Overall, gallic acid has exhibited great neuroprotective effects in various cellular or animal models in vitro and in vivo. As a result of regulation of antioxidant enzyme activities, neuroinflammatory cytokines, cytosolic Ca 2+ concentration, and ROS generation, gallic acid could prevent neuronal death, and increase the learning and passive avoidance memory.…”

Section: Degenerative Diseasementioning

confidence: 99%

A Role of Gallic Acid in Oxidative Damage Diseases: A Comprehensive Review

Gao

et al. 2019

Natural Product Communications

117

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Gallic acid is a trihydroxybenzoic acid of plant metabolites widely spread throughout the plant kingdom. It has characteristics of the strong antioxidant and free radical scavenging activities, and can protect biological cells, tissues, and organs from damages caused by oxidative stress. This review aims to summarize the protective roles of gallic acid and the underlying pharmacological mechanisms in the pathophysiological process of the oxidative damage diseases, such as cancer, cardiovascular, degenerative, and metabolic diseases. The studies reviewed herein showed that the main therapeutic effects of gallic acid were attributed to its antioxidant properties. It modulated various signaling pathways through a wide range of inflammatory cytokines, and enzymic and nonenzymic antioxidants. However, the available data were limited to few studies assessing the treatment effects of gallic acid in human subjects to confirm its therapeutic outcomes. Therefore, the clinical trials were urgently needed to investigate the safety and efficacy of gallic acid treatment on human beings. The scientific data summarized in this review highlighted the therapeutic potentials of gallic acid for oxidative damage diseases. It could be developed as versatile adjuvant or therapeutically lead compound in future.

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Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats

Cited by 67 publications

References 46 publications

Effects of gallic acid on exploratory behavior and locomotor activity in rats

Effects of gallic acid on exploratory behavior and locomotor activity in rats

Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical

A Role of Gallic Acid in Oxidative Damage Diseases: A Comprehensive Review

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