Protective effects of fucoxanthin against ferric nitrilotriacetate-induced oxidative stress in murine hepatic BNL CL.2 cells

Liu, Cheng-Ling; Liang, Ai‐Ling; Hu, Miao‐Lin

doi:10.1016/j.tiv.2011.04.023

Cited by 37 publications

(24 citation statements)

References 33 publications

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“…Liu et al [ 53 ] demonstrated that pretreatment with fucoxanthin (1–20 μ M) for 24 h could protect the murine hepatic BNL CL.2 cells against oxidative damage induced by ferric nitrilotriacetate (Fe-NTA). They [ 53 ] found that when the incubation of BNL CL.2 cells was treated with Fe-NTA for 30 min, cell proliferation was obviously decreased. However, fucoxanthin significantly recovered cell proliferation in a dose-dependent manner.…”

Section: Pharmacological Activities Of Fucoxanthinmentioning

confidence: 99%

Fucoxanthin: A Promising Medicinal and Nutritional Ingredient

Zhang

Tang

Ying

et al. 2015

Evidence-Based Complementary and Alternative Medicine

158

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Fucoxanthin, an allenic carotenoid, can be isolated from edible brown seaweeds. Recent studies have reported that fucoxanthin has many physiological functions and biological properties, such as antiobesity, antitumor, antidiabetes, antioxidant, anti-inflammatory, and hepatoprotective activities, as well as cardiovascular and cerebrovascular protective effects. Therefore, fucoxanthin can be used as both medicinal and nutritional ingredient to prevent and treat chronic diseases. Although fucoxanthin possesses many medicinal ingredient and nutritional qualities, studies indicated that its structure was unstable. In this paper, we consulted the current documents and reviewed structural properties and factors affecting the stability of fucoxanthin. We also reported the metabolism, safety, pharmacological activities, and the methods of improving the bioavailability of fucoxanthin. Based on these studies providing essential background knowledge, fucoxanthin can be developed into marine drugs and nutritional products.

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Section: Pharmacological Activities Of Fucoxanthinmentioning

confidence: 99%

Fucoxanthin: A Promising Medicinal and Nutritional Ingredient

Zhang

Tang

Ying

et al. 2015

Evidence-Based Complementary and Alternative Medicine

158

View full text Add to dashboard Cite

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“…The extract of Ishige okamurae has shown various biological activities in vitro and in vivo such as antioxidant, anti-diabetes and neuro-protective effect (Heo et al, 2012;Min, Kim, Jeon, & Han, 2011). Among these pigment, fucoxanthin are found in brown algae and chrysophyta, have been reported to improve oxidative stress and metabolic syndrome such as anti-diabetes and anti-obesity (Kang et al, 2011;Kumar, Hosokawa, & Miyashita, 2013;Liu, Liang, & Hu, 2011;Maeda, Hosokawa, Sashima, Funayama, & Miyashita, 2005;Maeda, Hosokawa, Sashima, & Miyashita, 2007;Nishikawa, Hosokawa, & Miyashita, 2012;Woo et al, 2010). Therefore, in the present study, we investigated the protective effects of fucoxanthin against high glucose level induced oxidative damage in human umbilical vein endothelial cells (HUVEC) and zebrafish model.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

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Available online A B S T R A C THigh glucose induced oxidative stress is implicated in intracellular toxicity in tissue and blood vessel such as oxidative stress, lipid peroxidation, and cell death. In this study, we attempted to investigate protective effects of fucoxanthin isolated from Ishige okamurae against high glucose induced oxidative stress in human umbilical vein endothelial cells (HUVEC) and zebrafish model. The ROS generation, lipid peroxidation and cell death were significantly reduced in both the fucoxanthin treated HUVEC and zebrafish in vivo model, compared to those of both negative controls. This study indicates that fucoxanthin could protect cells and organ injury against oxidative stress induced by high glucose in vitro HUVEC and in vivo zebrafish model.

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“…This carotenoid has been shown to have several biological functions, such as antioxidant activity [34,35,36,37], anti-obese effect [38,39], antidiabetic activity [40], antimutagenicity [41], anti-inflammation [42,43], and anticancer effects [44,45]. A previous report revealed that inhibition of proliferation of human hepatoma HepG2 cells by fucoxanthin is related to cell cycle arrest by downregulation of cyclin D and induction of GADD45A gene expression [45,46,47].…”

Section: Introductionmentioning

confidence: 99%

Fucoxanthin Enhances Cisplatin-Induced Cytotoxicity via NFκB-Mediated Pathway and Downregulates DNA Repair Gene Expression in Human Hepatoma HepG2 Cells

Liu

Lim

2013

Marine Drugs

Self Cite

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Cisplain, a platinum-containing anticancer drug, has been shown to enhance DNA repair and to inhibit cell apoptosis, leading to drug resistance. Thus, the combination of anticancer drugs with nutritional factors is a potential strategy for improving the efficacy of cisplatin chemotherapy. In this study, we investigated the anti-proliferative effects of a combination of fucoxanthin, the major non-provitamin A carotenoid found in Undaria Pinnatifida, and cisplatin in human hepatoma HepG2 cells. We found that fucoxanthin (1–10 μΜ) pretreatment for 24 h followed by cisplatin (10 μΜ) for 24 h significantly decreased cell proliferation, as compared with cisplatin treatment alone. Mechanistically, we showed that fucoxanthin attenuated cisplatin-induced NFκB expression and enhanced the NFκB-regulated Bax/Bcl-2 mRNA ratio. Cisplatin alone induced mRNA expression of excision repair cross complementation 1 (ERCC1) and thymidine phosphorylase (TP) through phosphorylation of ERK, p38 and PI3K/AKT pathways. However, fucoxanthin pretreatment significantly attenuated cisplatin-induced ERCC1 and TP mRNA expression, leading to improvement of chemotherapeutic efficacy of cisplatin. The results suggest that a combined treatment with fucoxanthin and cisplatin could lead to a potentially important new therapeutic strategy against human hepatoma cells.

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Protective effects of fucoxanthin against ferric nitrilotriacetate-induced oxidative stress in murine hepatic BNL CL.2 cells

Cited by 37 publications

References 33 publications

Fucoxanthin: A Promising Medicinal and Nutritional Ingredient

Fucoxanthin: A Promising Medicinal and Nutritional Ingredient

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Fucoxanthin Enhances Cisplatin-Induced Cytotoxicity via NFκB-Mediated Pathway and Downregulates DNA Repair Gene Expression in Human Hepatoma HepG2 Cells

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