Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang, Min‐Cheol; Lee, Seung‐Hong; Lee, Won Woo; Kang, Ning; Kim, Eun-A; Kim, Seo Young; Lee, Dong Hoon; Kim, Daekyung; Jeon, You‐Jin

doi:10.1016/j.jff.2014.09.007

Cited by 35 publications

(22 citation statements)

References 51 publications

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“…Several studies have reported that among the pigments of brown algae, fucoxanthin can reduce oxidative stress and symptoms of metabolic syndrome via its anti-diabetic and anti-obesogenic effects [54,55,56,57]. In addition, Kang et al [58] reported that fucoxanthin isolated from IO can reduce high glucose-induced oxidative stress in human umbilical vein endothelial cells (HUVEC) and in zebrafish models. Taken together, the antioxidative effects of IO may be effective as supplementary treatment of metabolic syndrome, including obesity and diabetes.…”

Section: Composition Of Iomentioning

confidence: 99%

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Yang

Fernando

et al. 2019

Marine Drugs

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Obesity is associated with several health complications and can lead to the development of metabolic syndrome. Some of its deleterious consequences are related to insulin resistance, which adversely affects blood glucose regulation. At present, there is a growing concern regarding healthy food consumption, owing to awareness about obesity. Seaweeds are well-known for their nutritional benefits. The brown alga Ishige okamurae (IO) has been studied as a dietary supplement and exhibits various biological activities in vitro and in vivo. The bioactive compounds isolated from IO extract are known to possess anti-obesity and anti-diabetic properties, elicited via the regulation of lipid metabolism and glucose homeostasis. This review focuses on IO extract and its bioactive compounds that exhibit therapeutic effects through several cellular mechanisms in obesity and diabetes. The information discussed in the present review may provide evidence to develop nutraceuticals from IO.

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Section: Composition Of Iomentioning

confidence: 99%

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Yang

Fernando

et al. 2019

Marine Drugs

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“…Ishige okamurae is a brown seaweed widespread in South Korea throughout Japan to China. The ethanolic extract of I. okamurae has shown antioxidant, antidiabetes, antihypertension, and antiobesity effects [15,16,17]. Recent evidence reported that diphlorethohydroxycarmalol (DPHC) isolated from I. okamurae could efficiently induce apoptosis via downregulating Bcl-2 while activating Bax caspase-3 and caspase-9 in adipocyte cells [18].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Adipogenesis by Diphlorethohydroxycarmalol (DPHC) through AMPK Activation in Adipocytes

et al. 2019

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The purpose of this study was to investigate the antiobesity effect and the mechanism of action of diphlorethohydroxycarmalol (DPHC) isolated from Ishige okamurae in 3T3-L1 cells. The antiobesity effects were examined by evaluating intracellular fat accumulation in Oil Red O-stained adipocytes. Based on the results, DPHC dose-dependently inhibited the lipid accumulation in 3T3-L1 adipocytes. DPHC significantly inhibited adipocyte-specific proteins such as SREBP-1c, PPARγ, C/EBP α, and adiponectin, as well as adipogenic enzymes, including perilipin, FAS, FABP4, and leptin in adipocytes. These results indicated that DPHC primarily acts by regulating adipogenic-specific proteins through inhibiting fat accumulation and fatty acid synthesis in adipocytes. DPHC treatment significantly increased both AMPK and ACC phosphorylation in adipocytes. These results indicate that DPHC inhibits the fat accumulation by activating AMPK and ACC in 3T3-L1 cells. Taken together, these results suggest that DPHC can be used as a potential therapeutic agent against obesity.

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“…Epidemiological data has suggested that the regular consumption of seaweeds can reduce the risk of developing diseases associated with oxidative stress. As a dietary antioxidant, fucoxanthin improves the antioxidant capacity of blood serum levels (Kang et al 2014), and is capable of quenching reactive oxygen species under hypoxic physiological conditions, unlike the majority of food-derived antioxidants (Kaneko et al 2013). Reactive oxygen species are known to cause cellular damage, which is implicated in the pathogenesis of disorders such as cardiovascular disease, cancer, metabolic syndrome, and type II diabetes.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

Shannon¹,

Abu‐Ghannam²

2016

J Appl Phycol

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Fucoxanthin is a xanthophyll pigment which occurs in marine brown algae (Phaeophyceae). The anti-diabetic, anti-obesity, anti-cancer, and antioxidant properties of fucoxanthin have been widely reported. Macroalgae, particularly brown seaweeds, grow prolifically around Irish coasts, representing a valuable resource of nutraceuticals such as fucoxanthin for functional food applications. The aim of this study was to maximise the solvent extraction yield from three anatomically discrete regions of the seaweed thallus: blade, stipe, and holdfast. Response surface methodology was applied to determine optimum parameters for extraction of fucoxanthin from the seaweed, Fucus vesiculosus, as a model species. A central composite design was applied with four extraction variables: time (30-70 min), temperature (30-70°C), solvent pH (5.0-9.0), and percentage acetone (30-70 %). Fucoxanthin content of extracts was quantified by highperformance liquid chromatography. Percentage acetone was found to have the most significant (P = 0.0002) effect on fucoxanthin yield, followed by pH (P = 0.028) and temperature (P = 0.049). Multiple response optimisation determined that fucoxanthin yield from F. vesiculosus may be maximised by incubating at 30.0°C for 36.5 min, pH 5.7, with 62.2 % acetone. Optimised responses were applied to a further nine brown seaweeds; Alaria esculenta, Ascophyllum nodosum, Fucus serratus, Himanthalia elongata, Laminaria digitata, Laminaria hyperborea, Pelvetia canaliculata, Saccharina latissima, and Saccorhiza polyschides. In all species, the blades contained significantly more fucoxanthin than stipes, while holdfasts contained the least. Alaria esculenta blade had the greatest yield (0.870 mg g −1 dry mass), followed by ).

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Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Cited by 35 publications

References 51 publications

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Inhibition of Adipogenesis by Diphlorethohydroxycarmalol (DPHC) through AMPK Activation in Adipocytes

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

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