Protective Effects of Fruits and Vegetables against In Vivo Clastogenicity of Cyclophosphamide or Benzo[a]pyrene in Mice

Edenharder, R.; Frangart, J.; Häger, M; Hofmann, Patrick; Rauscher, R.

doi:10.1016/s0278-6915(98)00035-0

Cited by 30 publications

(16 citation statements)

References 24 publications

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“…In this context, an important focus of the search is to understand the true effi cacy of plant materials and determine its mechanism of action in different experimental models (RomeroJiménez et al, 2005). Although human body is equipped with self defense mechanisms such as detoxifi cation process through various enzymes, serious exposure to dangerous chemicals can cause changes in the genetic material (mutations) leading to carcinogenic events (Edenharder et al, 1998;Belitsky & Yakubovskaya, 2008). Cyclophosphamide (CP), an antineoplastic agent, and its metabolites can bind DNA, causing damage that may result in chromosome breaks, micronucleus formation and cell death (Murata et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimão") leaf extracts

Filho¹,

Ferreira²,

Gouvêa³

2011

Rev. bras. farmacogn.

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The present study describes for the first time the antigenotoxic and antioxidant properties of Stryphnodendron adstringens (Mart.) Coville, Fabaceae ("barbatimão") leaves. The aqueous (AEB), water fraction (WFB) and ethanolic (EEB) extracts of leaves were obtained and they presented high content of phenolic compounds, flavonoids and proanthocyanidins. WFB and EEB inhibited the genotoxicity induced by cyclophosphamide. WFB inhibited the DNA lesion formation and both WFB and EEB decreased significantly (p<0.05) micronucleus formation. All extracts also showed high DPPH radical scavenging activity and reducing power. In conclusion all extracts presented antioxidant activity and WFB and EEB protected cells from genotoxicity induced by cyclophosphamide in rat bone marrow cells. Thus, our results support the beneficial effects of the barbatimão extracts as an anticarcinogenic agent.

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Section: Introductionmentioning

confidence: 99%

Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimão") leaf extracts

Filho¹,

Ferreira²,

Gouvêa³

2011

Rev. bras. farmacogn.

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“…1 Many natural compounds in plants have been reported to have potential protective effects on these diseases as well as anticarcinogenic effects. 2 Medicinal plants have potential preventive properties because of chemical constituents such as phenolic compounds and flavonoids. Flavonoids and phenolic compounds have many biological properties, including hepa toprotective, antibacterial, and anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Chemoprotective Effects of Zataria multiflora Against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells

et al. 2010

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The preventive effective of Zataria multiflora (ZM) extract was investigated in mouse bone marrow cells against genotoxicity induced by cyclophosphamide (CP). Mice were orally (gavaged) pretreated with solutions of ZM extract prepared at 3 different doses (50, 100, and 200 mg/kg body weight) for 7 consecutive days. They were injected with CP (50 mg/kg body weight) on the seventh day of treatment and killed after 24 hours for the evaluation of micronucleated polychromatic erythrocytes (MnPCEs) and the ratio of PCE/(PCE + NCE), where PCE refers to polychromatic erythrocyte, and NCE refers to normochromatic erythrocyte. All 3 doses of extract significantly reduced MnPCEs induced by CP (P < .0001). Zataria extract at a dose of 200 mg/kg body weight reduced MnPCEs 7.8 fold and also completely normalized the PCE/ (PCE + NCE) ratio. Administration of ZM inhibited bone marrow suppression induced by CP. Zataria extract exhibited concentration-dependent antioxidant activity on 1, 1-diphenyl 2-picryl hydrazyl free radical and lipid peroxidation. It appeared that ZM with antioxidative activity reduced the oxidative stress and genotoxicity induced by CP in mouse bone marrow cells.

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“…In vivo micronucleus test can be a useful short term test the serving explanation of the mechanisms and the identification of chemical compounds responsible for anticlastogenic effect. EDENHARDER et al (1998) proved anticlastogenic effects of fruits and vegetables, commonly consumed in Germany, against benzo(a)pyrene and cyclophosphamide. Similar effects were confirmed in the subsequent study (EDENHARDER et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Chemoprotective Effects of Broccoli Juice Treated with High Pressure

Mandelová¹,

Totušek²

2006

Czech J. Food Sci.

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We investigated chemoprotective effects of broccoli juice, treated with high pressure method, using 500 MPa for a period of 10 minutes. By the use of this method, the conservation of nutritionally important substances occurs (for example vitamins, polyphenolic compounds, glucosinolates and other constituent substances). We followed the inhibition of mutagenicity of the model mutagen, N-nitroso-N-methylurea (MNU), by means of in vivo micronucleus test. After fourteen-day application of broccoli juice (0.2 ml/10 g of body weight of mouse) and after a single administration of MNU mutagen (50 mg/kg), a statistically significant decrease (p < 0.01) occurred of the number of micronuclei induced by the application of MNU. Broccoli juice treated with high pressure therefore seems to have a preventive potential against MNU-induced micronuclei formation in BALB/C mouse bone marrow cells.

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Protective Effects of Fruits and Vegetables against In Vivo Clastogenicity of Cyclophosphamide or Benzo[a]pyrene in Mice

Cited by 30 publications

References 24 publications

Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimão") leaf extracts

Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimão") leaf extracts

Chemoprotective Effects of Zataria multiflora Against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells

Chemoprotective Effects of Broccoli Juice Treated with High Pressure

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