Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase‐2, in experimental periodontitis in rats

Holzhausen, Marinella; Spolidório, Denise Madalena Palomari; Muscará, Marcelo Nícolas; Hebling, Josimeri; Spolidório, Luís Carlos

doi:10.1111/j.1600-0765.2005.00787.x

Cited by 47 publications

(55 citation statements)

References 17 publications

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“…We used a delayed treatment model starting 5 days after the induction of periodontitis, when bone loss is already demonstrable (30). This approach more closely resembles the situation in clinical outpatient practice rather than an early treatment (18).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats

Azoubel¹,

Menezes²,

Bezerra³

et al. 2007

Braz J Med Biol Res

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We investigated the effect of etoricoxib, a selective cyclooxygenase-2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhibitor, on experimental periodontitis, and compared their gastrointestinal side effects. A ligature was placed around the second upper left molars of female Wistar rats (160 to 200 g). Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day. The weight and survival rate were monitored. Alveolar bone loss (ABL) was measured as the sum of distances between the cusp tips and the alveolar bone. The gastric mucosa was examined macroscopically and the periodontium and gastric and intestinal mucosa were examined by histopathology. The ongoing ABL was significantly inhibited (P < 0.05) by 3 and 9 mg/kg etoricoxib and by indomethacin: control = 4.08 ± 0.47 mm; etoricoxib (3 mg/kg) = 1.89 ± 0.26 mm; etoricoxib (9 mg/kg) = 1.02 ± 0.14 mm; indomethacin = 0.64 ± 0.15 mm. Histopathology of periodontium showed that etoricoxib and indomethacin reduced inflammatory cell infiltration, ABL, and cementum and collagen fiber destruction. Macroscopic and histopathological analysis of gastric and intestinal mucosa demonstrated that etoricoxib induces less damage than indomethacin. Animals that received indomethacin presented weight loss starting on the 7th day, and higher mortality rate (58.3%) compared to etoricoxib (0%). Treatment with etoricoxib, even starting when ABL is detected, reduces inflammation and cementum and bone resorption, with fewer gastrointestinal side effects.

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Section: Discussionmentioning

confidence: 99%

“…A recent study has documented a preventive benefit of etoricoxib (18). However, the mode of treatment with etoricoxib, a selective COX-2 inhibitor, has been poorly studied in periodontal disease models.…”

Section: Introductionmentioning

confidence: 99%

Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats

Azoubel¹,

Menezes²,

Bezerra³

et al. 2007

Braz J Med Biol Res

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“…Stereomicroscopic evaluation (Olympus SZ-PT, Tokyo, Japan) confirmed these observations; the maxillae were photographed (Olympus C-4000 ZOOM, Tokyo, Japan) under the stereomicroscope and are shown in Figure 1A. The present study employed the direct digital radiography method (22,23; Figure 1B). The stereomicroscopic and digital radiographic evaluations were conducted only to evidence the periodontal breakdown.…”

Section: Determination Of the Presence Of Periodontitismentioning

confidence: 79%

Deneysel periodontitiste fazla kilolu olma durumunun dolaşımdaki sitokinler ve adipokinler üzerine etkisi

2017

SDÜ Sağlık Bilimleri Dergisi

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Objective: Interleukin (IL)-1β, IL-4, IL-6, and tumor necrosis factor (TNF-α) are forefront cytokines in the periodontitis pathogenesis. Therefore, this study aimed to test the hypothesis that overweight rats with periodontitis have higher pro-inflammatory cytokines and/or adipokines, and lower anti-inflammatory cytokines and/or adipokines in serum than normal weight rats. Material-Method: Thirty-two 4-month old male Wistar rats were divided into 4 groups: normal weight, periodontally healthy rats (NH, n = 8), normal weight rats with periodontitis (NP, n = 8), overweight, periodontally healthy rats (OH, n = 8); and overweight rats with periodontitis (OP, n = 8). Periodontitis was induced by ligature for 14 days. The serum cytokine' and adipokine' levels were investigated using ELISA. Results: IL-4 levels were higher in the NH and NP groups than their counterparts in the overweight rats (p<0.01). The IL-6 level was significantly higher in the OP group than in the NP group (p<0.01). The adiponectin level was significantly higher in the NH group than in the OH and OP groups (p<0.01). Leptin and resistin levels didn't differ significantly among the groups (p>0.01). Conclusions:The overweight status affected the cytokine' and adipokine' level independent from the periodontal status in this experimental model. Overweight rats with and without periodontitis have lower serum levels of anti-inflammatory cytokine and adipokines (IL-4 and adiponectin) and higher serum levels of pro-inflammatory cytokine (IL-6) than their counterparts in normal weight rat groups.

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“…(16) Other investigators have conducted experiments over much longer periods of time. (17) Fernandeset al (18) compared the histometric and morphometric methods and found that both are capable of detecting alveolar bone loss in rats. Li and Amar (19) likewise compared the different methods-morphometric isolated, histometric and morphometric associated and micro-computed tomography-in 100 male rats, and their findings showed that all the methods are accurate for quantification of alveolar bone loss (20) .The histological results of the present study revealed that in control ligature group lack of normal architechture of periodontal ligament (PDL), resorptive bays on bone detachment associatedwith PDL detachment in certain areas, In vehicle group, total degeneration of PDL, lack of normal architecture of PDL and resorptive bone area, Using watery extract of lepiduimsativum, at 15 days there were gradual healing of PDL with marked reduction in marrow spaces numbers, completebone attachment, while in 30 days, almost complete regeneration of PDL and reversal lines are observed.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Different Extract of LepidiumSativum on Induced Periodontitis in Dexamethasone Immunosuppressed Rats

Elsayed¹,

Elkilani²,

Farid³

2017

ADJ-for Girls

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Objective : The present study was designated to evaluate the effect of lepidiumsativum extract on structure and density of bone in immunosuppressed rats with induced chronic periodontitis histologically, hostometrically as well as radiodensitometric analysis by digital radiography assessment (vista scan). Materials and methods: A total 36 wistar male rats were divided randomly into 6 groups (6 rats/group). The study sample was divided into:I -Control group: in this group rats were fed with a normal diet.II-Control group with ligature: without receiving dexamethasone injection, a sub marginal cotton ligature.III-Vehicle group: in this group rats were received a weekly dose of dexamethasone for 6 weeks and received sub marginal cotton ligature (no treatment). SRP 1 (methanol group): rats were received methanol extract for 30 days, these were subjected to scaling and root planning (SRP). SRP 2 (watery group): in this group rats were subjected to (SRP). SRP 3 group submitted only to SRP and received no further treatment.Results: methanol extract has better anabolic effect on bone and regenerative on periodontal ligaments than watery extract.This could be explained by the fact that lepidiumsativum possesses anti-inflammatory, immunomodulatory properties and antioxidative activity that may resolve periodontal inflammation.

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Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase‐2, in experimental periodontitis in rats

Abstract: These data provide evidence that systemic therapy with etoricoxib can retard alveolar bone loss in a ligature-induced periodontitis model in rats.

Cited by 47 publications

References 17 publications

Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats

Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats

Deneysel periodontitiste fazla kilolu olma durumunun dolaşımdaki sitokinler ve adipokinler üzerine etkisi

The Effects of Different Extract of LepidiumSativum on Induced Periodontitis in Dexamethasone Immunosuppressed Rats

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