Protective Effects of Erdosteine and Vitamins C and E Combination on Ischemia–Reperfusion-Induced Lung Oxidative Stress and Plasma Copper and Zinc Levels in a Rat Hind Limb Model

Sırmalı, Mehmet; Uz, Efkan; Sirmali, Rana; Kilbas, Aynur; Yılmaz, H. Ramazan; Altuntaş, İrfan; Nazıroğlu, Mustafa; Delibas, Namik; Vural, Hüseyín

doi:10.1007/s12011-007-0010-3

Cited by 26 publications

(18 citation statements)

References 33 publications

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“…4,5 The role of neutrophils and oxidative damage in the lung and liver following lower I/R injury is well documented. 17,18,22 Increased alveolar fluid gene expression for tumor necrosis factor-a, interferon-g, interleukin-1b, and macrophage inflammatory protein-2 have been found in anesthetized rats after inhalation of volatile anesthetics. 23 However, the authors did not study anesthesia conducted with desflurane.…”

Section: Discussionmentioning

confidence: 99%

New volatile anesthetic, desflurane, reduces vitamin E level in blood of operative patients via oxidative stress

Eroğlu

Yavuz

Ceylan

et al. 2010

Cell Biochemistry & Function

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It has been well known that some volatile anesthetic agents produce oxidative stress. Desflurane as a new volatile agent might have limited oxidative toxic effect because it is relatively a new short-acting anesthetic characterized by a short duration of action and a quick postanesthetic recovery. We investigated effect of desflurane on serum glutathione peroxidase (GSH-Px), lipid peroxidation (LP), vitamin E, and erythrocyte superoxide dismutase (SOD) values in patients. Fifteen adult patients are scheduled for elective surgery, ASA I or II physical status. Tidal volume and ventilation frequency were kept unchanged during the operation. Baseline values in venous blood samples were preoperatively taken and blood was also taken postoperatively at the 1st and the 12th hours of desflurane exposure. LP levels were significantly (p < 0.05) higher postoperatively at 1st hour than in preoperative values while alpha-tocopherol concentration was significantly (p < 0.001) lower in postoperative period at 1st hour than in preoperative period. Erythrocyte SOD and serum GSH-Px activities did not differ between pre- and postoperative periods. In conclusion, we observed that desflurane produced oxidative stress by decreasing alpha-tocopherol levels. Use of vitamin E may be possible to reduce the oxidative effect of desflurane.

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Section: Discussionmentioning

confidence: 99%

New volatile anesthetic, desflurane, reduces vitamin E level in blood of operative patients via oxidative stress

Eroğlu

Yavuz

Ceylan

et al. 2010

Cell Biochemistry & Function

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“…The biomedical roles of Se include its actions in the antioxidant defense against oxidative stress, protection against cardiovascular diseases, cancers, and physiological functions in the nervous system [8][9][10]. It has been shown that selenium exerts protective effects against ischemia-reperfusion of lung [11], brain disorders [12], and chemotherapeutic drug-induced liver oxidative injury [13]. These effects of selenium are attributed to its role in reducing oxidative stress and inhibition of apoptosis [8,14].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Selenium on Oxidative Stress Induced by Waterpipe (Narghile) Smoke in Lungs and Liver of Mice

Charab

Abouzeinab

Moustafa

2016

Biol Trace Elem Res

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Waterpipe smoking is common in the Middle East populations and results in health problems. In this study, we investigated the effects of exposure of mice to waterpipe smoke on oxidative stress in lungs and liver and the effects of selenium administration before smoke exposure on the oxidative stress. Twenty-four mice were divided equally into four groups: (i) the control mice received no exposure or treatment; (ii) mice exposed to waterpipe smoke; (iii) mice received intraperitoneal injection of 0.59 μg selenium/kg body weight as sodium selenite 15 min before the exposure to waterpipe smoke; and (iv) mice received intraperitoneal injection of 1.78 μg selenium/kg body weight as sodium selenite 15 min before the exposure to waterpipe smoke. Mice were exposed to waterpipe smoke every other day for four times within 8 successive days. Malondialdehyde and nitric oxide levels were significantly higher in the lungs and liver, while the activities of superoxide dismutase, glutathione peroxidase-1, and catalase were significantly lower in the waterpipe smoke group when compared to control mice. Treating mice with 1.78 μg selenium/kg body weight significantly restored the normal levels of these parameters. Histological examinations of lungs and liver confirmed the protective actions of selenium against the effects of exposure to waterpipe smoke. In conclusion, exposure of mice to waterpipe smoke-induced oxidative stress in lungs and liver. Administration of low level of selenium, 1.78 μg selenium/kg body weight as sodium selenite, exerted protective effects against oxidative stress induced by exposure to waterpipe smoke.

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“…25,35 In addition to its mucolytic action, Met I also is an useful antioxidant. 13 In current study, we showed histopathological changes such as cellular disruption, cell vacuolization and central necrosis in rats received RCM. These changes show that RCM administration lead to cellular disruption and hepatocellular necrosis in liver tissue.…”

Section: Discussionmentioning

confidence: 56%

“…9,13 Administration of RCM is characterized by activation of the inflammatory response system. 12,23 TBARS levels is a major oxidative degradation product of membrane unsaturated fatty acid and has been shown to be biologically active with ROS properties.…”

Section: Discussionmentioning

confidence: 99%

“…The reducing potential of these sulfhydryl groups accounts for free radical scavenging and antioxidant activity of erdosteine. 13 In many studies, erdosteine has been successfully used as a preventive agent against various toxic agents in animals and humans via inhibition of I/R injury of cells. 2,13 Therefore, erdosteine seems to be a promising protector agent against ROS-induced damage in many pathologic conditions.…”

Section: Introductionmentioning

confidence: 99%

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Erdosteine modulates radiocontrast‐induced hepatotoxicity in rat

Yeşildağ

Özden

Yilmaz

et al. 2009

Cell Biochemistry & Function

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It has been suggested that reactive oxygen species (ROS) plays an important role in radio contrast media (RCM)-induced ischemia reperfusion tissue injury although antioxidants may have protective effects on the injury. We investigated the effects of erdosteine as an antioxidant agent on RCM-induced liver toxicity in rats by evaluation of lipid peroxidation (as TBARS), catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) values and histological evaluation. Twenty-one rats were equally divided into three groups as follows: control, RCM, and RCM plus erdosteine. RCM was intraperitoneally administered for 1 day. Erdosteine was administered orally for 2 days after RCM administration. Liver samples were taken from the rats and they homogenized in a motor-driven tissue homogenizer. TBARS levels were significantly (p < 0.005) higher in RCM group than in control although SOD activities significantly (p < 0.05) decreased in RCM group. TBARS levels were lower in RCM plus erdosteine group than in control although SOD activity and GSH level increased (p < 0.05) in liver as compared to RCM alone. Erdosteine showed also histopathological protection (p < 0.0001) against RCM induced hepatotoxicity. GSH-Px and CAT activities were not statistically changed by the erdosteine. According to our results, it can be concluded that radiocontrast media can induce oxidative stress in liver as suggested by previous studies. Erdosteine seems to be protective agent on the radiocontrast media-induced liver toxicity by inhibiting the production of ROS via the enzymatic antioxidant system.

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Protective Effects of Erdosteine and Vitamins C and E Combination on Ischemia–Reperfusion-Induced Lung Oxidative Stress and Plasma Copper and Zinc Levels in a Rat Hind Limb Model

Cited by 26 publications

References 33 publications

New volatile anesthetic, desflurane, reduces vitamin E level in blood of operative patients via oxidative stress

New volatile anesthetic, desflurane, reduces vitamin E level in blood of operative patients via oxidative stress

The Protective Effect of Selenium on Oxidative Stress Induced by Waterpipe (Narghile) Smoke in Lungs and Liver of Mice

Erdosteine modulates radiocontrast‐induced hepatotoxicity in rat

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