Protective effects of edible Rhus tripartita (Ucria) stem extract against ethanol-induced gastric ulcer in rats

Barka, Zaineb Ben; Tlili, Mounira; Alimi, Hichem; Miled, Hanène Ben; Rhouma, Khémaïs Ben; Sakly, Mohsen; Ksouri, Riadh; Schneider, Yves Jacques; Tebourbi, Olfa

doi:10.1016/j.jff.2017.01.021

Cited by 27 publications

(14 citation statements)

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“…Different mechanisms of gastric cytoprotection have been suggested, including increased gastric mucosal blood flow, free radical scavenging, and stimulation of cell growth and repair [ 64 ]. In the current study, consistent with previous findings, administration of 80% ethanol solution by intragastric gavage produced marked damage in the gastric mucosa of rats, characterized mainly by elongated macroscopic lesions with intense hemorrhaging and hyperemia, as well as loss of mucus [ 35 , 65 , 66 ]. Pre-treatment of rats for eight days with ExPhy markedly attenuated gastric damage and promoted healing of gastric mucosa lesions induced by ethanol, although to a lesser extent than the standard drug, omeprazole.…”

Section: Discussionsupporting

confidence: 92%

“…In accordance with previous studies, the ulcer control group showed typical histological damage 1 h after ethanol administration. This damage was characterized by vascular congestion, submucosal edema formation, loss of gastric mucosa integrity, and necrotic tissue injury, as well as an inflammatory response characterized by neutrophil and eosinophil infiltration [ 65 , 69 , 70 ]. The aggregation of neutrophils plays a fundamental role in the process of injury and inflammation in the gastric mucosa due to their release of tissue-disruptive substances like proteases, leukotrienes B4 (LTB4), and reactive oxygen species [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

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Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima

et al. 2018

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Phycobiliproteins of Arthrospira (Spirulina) maxima have attracted attention because of their potential therapeutic antioxidant properties. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins (ExPhy) against ethanol-induced gastric ulcers in rats. To explore the possible mechanisms of action, we examined antioxidant defense enzymes (e.g., catalase, superoxide dismutase, and glutathione peroxidase), as well as the level of lipid peroxidation (MDA) and the histopathological changes in the gastric mucosa. Intragastric administration of ExPhy (100, 200, and 400 mg/kg body weight) significantly lowered the ulcer index value compared to the ulcer control group (p < 0.05). The greatest protection was provided by the concentration of 400 mg/kg. The histological study supported the observed gastroprotective activity of ExPhy, showing a reduced inflammatory response. Moreover, the alcohol-induced decrease in stomach antioxidant enzyme activity found in the ulcer control group was prevented by ExPhy pretreatment. Furthermore, ExPhy reversed the ethanol-induced increase in lipid peroxidation. In summary, the antiulcerogenic potential of ExPhy may be due, at least in part, to its anti-oxidant and anti-inflammatory effects.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima

et al. 2018

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“…We also investigated the self-made BJO’s effects on gastric ulcer. The animal models were induced by ethanol administration since ethanol could produce necrotic damage penetrating deeply into the mucosa, 21 disappearance of the mucus cells, 22 hemorrhagic erosion 23 and inflammatory cell infiltration. 21 As expected, ethanol caused a marked gastric ulceration in the present study.…”

Section: Discussionmentioning

confidence: 99%

Enhanced gastric therapeutic effects of <em>Brucea javanica</em> oil and its gastroretentive drug delivery system compared to commercial products in pharmacokinetics study

Zhang

et al. 2018

DDDT

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BackgroundBrucea javanica oil (BJO), a traditional Chinese herbal medicine, has a variety of pharmacological activities and several BJO-related patent drugs have been widely used in China.PurposeThe objective of this study was to evaluate the gastric therapeutic effects of self-made BJO and its pharmaceutical potential to formulate novel BJO gastroretentive floating bead by comparing with commercial products.MethodsBJO was extracted from the seeds of B. javanica, and its therapeutic effects were evaluated by comparing with commercial products in the treatment of human gastric cancer and gastric ulcer. Furthermore, the developed gastroretentive drug delivery system was evaluated by in vivo tests. A high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS) method for detecting the concentration of glycerol trioleate in the pharma-cokinetic study was applied.ResultsThe antitumor activity of BJO was stronger than that of the marketed preparation; the 50% inhibitory concentration (IC50) values of BJO extracts on HGC27, SGC7901 and BGC823 gastric carcinoma were 0.3091, 1.736 and 2.743 μg/mL, respectively, whereas the values of marked BJO preparation were 15.26, 32.60 and 7.456 μg/mL, respectively. Histopathological studies demonstrated the ability of BJO to locally prevent and treat absolute ethanol-induced gastric ulcer. Developed BJO gastroretentive floating bead showed a satisfactory in vivo study. The highest glycerol trioleate concentration in the stomach after taking BJO gastroretentive floating bead was nearly two times higher when compared to the marketed BJO soft capsule.ConclusionSelf-made BJO has a strong therapeutic effect on the stomach, and gastroretentive drug delivery system can be a promising approach to prolong and enhance its therapy ability when treating gastric diseases.

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“…Animals were kept on fasting overnight and orally received following different treatments : group I and II (normal and disease control respectively), group III; omeprazole (20 mg/kg) [24], group IV; ranitidine (30 mg/kg) [25] and group V; Lavandula stoechas L. extract (300 mg/kg) [26]. After 1 h, disease (gastric mucosal ulcer) was induced in animals (group II-V) by oral administration of 1 ml of ethanol (80%) [27]. After 5 h, animals were anesthetized using xylazine (10 mg/kg, intraperitoneal) & ketamine (100 mg/kg, intraperitoneal) [28] and sacrificed to obtain the stomach.…”

Section: Gastroprotective Potential Of Lavandula Stoechas L Extractmentioning

confidence: 99%

Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Javed

Khan

Arshad³

et al. 2020

RADS J. Pharm. Pharm. Sci.

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Background: The constituents of Lavandula stoechas L. possess antioxidant properties that help in protecting the mucosal cells from oxidative damage and speed up the healing process however, its role in the treatment of ethanol-induced peptic ulcers is not clear. Objectives: We aimed to evaluate the pharmacological potential of Lavandula stoechas L. extracts for anti-ulcer activity, and compare with the standard drugs and to explore novel treatment for peptic ulcer. Methods: We evaluated anti-ulcer potential of plant extract in ethanol-induced ulcer model in rats. Omeprazole and ranitidine were standard drugs. After 5 h of disease induction, animals were sacrificed to get tissues for histological evaluation and ulcer index was measured. While the antimicrobial potential of Lavandula stoechas L. aqueous and methanolic extracts was evaluated against different bacterial stains using standard antibiotic discs. Qualitative phytochemical and GCMS analysis were performed to identify novel constituents. Results: The methanolic extract of Lavandula stoechas L. showed antimicrobial activity against Proteus Mirabilis while the GCMS based analysis revealed the presence of 10 phytochemicals including camphor (antimicrobial agent). The aqueous extract showed significant anti-ulcer activity in ethanol-induced gastric (P < 0.001) and duodenal (P < 0.01) ulcers when compared with controls. Aqueous and methanolic Lavandula stoechas L. extracts showed strong free radical scavenging activity. Conclusion: Lavandula stoechas L. extract possess antimicrobial and anti-ulcer activity in alcohol-induced ulcer model in experimental animals.

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Protective effects of edible Rhus tripartita (Ucria) stem extract against ethanol-induced gastric ulcer in rats

Cited by 27 publications

References 50 publications

Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima

Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima

Enhanced gastric therapeutic effects of <em>Brucea javanica</em> oil and its gastroretentive drug delivery system compared to commercial products in pharmacokinetics study

Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

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