Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model

Lee, Kyungjin; Lee, Beom-Joon; Bu, Youngmin

doi:10.3390/molecules200711930

Cited by 21 publications

(16 citation statements)

References 35 publications

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“…CGA improved the behavioral outcome in a rabbit small clot embolic stroke model 174 . CGA and its metabolite dihydrocaffeic acid (DHCA) inhibited MMP-2/9 activity, attenuated BBB damage and reduced brain infarction and brain edema 175 , 176 . CGA also exerted anti-inflammatory effects against cerebral ischemia-reperfusion injury 177 , 178 .…”

Section: Natural Active Compounds Targeting Onoo − mentioning

confidence: 99%

Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

Chen

et al. 2018

Acta Pharmacol Sin

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Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-reperfusion injury. RNS activate multiple signaling pathways and participate in different cellular events in cerebral ischemia-reperfusion injury. Recent studies have indicated that caveolin-1 and matrix metalloproteinase (MMP) are important signaling molecules in the pathological process of ischemic brain injury. During cerebral ischemia-reperfusion, the production of nitric oxide (NO) and peroxynitrite (ONOO−), two representative RNS, down-regulates the expression of caveolin-1 (Cav-1) and, in turn, further activates nitric oxide synthase (NOS) to promote RNS generation. The increased RNS further induce MMP activation and mediate disruption of the blood-brain barrier (BBB), aggravating the brain damage in cerebral ischemia-reperfusion injury. Therefore, the feedback interaction among RNS/Cav-1/MMPs provides an amplified mechanism for aggravating ischemic brain damage during cerebral ischemia-reperfusion injury. Targeting the RNS/Cav-1/MMP pathway could be a promising therapeutic strategy for protecting against cerebral ischemia-reperfusion injury. In this mini-review article, we highlight the important role of the RNS/Cav-1/MMP signaling cascades in ischemic stroke injury and review the current progress of studies seeking therapeutic compounds targeting the RNS/Cav-1/MMP signaling cascades to attenuate cerebral ischemia-reperfusion injury. Several representative natural compounds, including calycosin-7-O-β-D-glucoside, baicalin, Momordica charantia polysaccharide (MCP), chlorogenic acid, lutein and lycopene, have shown potential for targeting the RNS/Cav-1/MMP signaling pathway to protect the brain in ischemic stroke. Therefore, the RNS/Cav-1/MMP pathway is an important therapeutic target in ischemic stroke treatment.

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Section: Natural Active Compounds Targeting Onoo − mentioning

confidence: 99%

Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

Chen

et al. 2018

Acta Pharmacol Sin

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“…In addition, dihydrocaffeic acid (DHCA), one of the metabolites of CGA and other natural products in coffee, also has protective effects on ischemic damage (Lee et al, 2015). Further studies are necessary in order to conclude that there is a direct association between treatment with CGA and ischemic stroke.…”

mentioning

confidence: 99%

Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicity

Mikami

Yamazawa

2015

Life Sciences

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“…231 In addition, dihydrocaffeic acid exhibited protective activities on ischemia-induced neuronal damage and brain edema cerebral on a focal cerebral ischemia rat model. 232 Besides, m-hydroxyphenylpropanoic acid displayed antioxidant effect 233 and decaffeoyl verbascoside possessed anti-inflammatory activity in vivo and vitro. 234 Therefore, we can make the conclusion that the metabolites of PhGs such as hydroxytyrosol, caffeic acid, 3-HPP, DCA, decaffeoyl verbascoside, and m-hydroxyphenylpropanoic are the active substances in vivo.…”

Section: Biotransformation Of Phgs By Microbiota In Vitromentioning

confidence: 98%

Therapeutic potential of phenylethanoid glycosides: A systematic review

Georgiev

Cao

et al. 2020

Medicinal Research Reviews

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Phenylethanoid glycosides (PhGs) are generally watersoluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antibacterial, anticancer, antidiabetic, anti-inflammatory, antiobesity, antioxidant, antiviral, and neuroprotective properties. Despite these promising benefits, PhGs have failed to fulfill their therapeutic applications due to their poor bioavailability. The attempts to understand their metabolic pathways to improve their bioavailability are investigated. In this review article, we will first summarize the number of PhGs compounds which is not accurate in the literature. The latest

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Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model

Cited by 21 publications

References 35 publications

Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicity

Therapeutic potential of phenylethanoid glycosides: A systematic review

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