Protective Effects of Dietary Cyanidin 3-O-β-d-Glucoside on Liver Ischemia–Reperfusion Injury in Rats

Tsuda, Takanori; Horio, Fumihiko; Kitoh, Junzoh; Osawa, Toshihiko

doi:10.1006/abbi.1999.1311

Cited by 135 publications

(90 citation statements)

References 30 publications

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“…Anthocyanins and their aglycons, anthocyanidins, have various biological effects, such as antioxidative activity (Cao et al, 1997;Kahkonen and Heinonen, 2003;Rahman et al, 2006;Tsuda et al, 1999a), anti-hyperglycemic activity (Matsui et al, 2002), anti-inflammatory activity (Karlsen et al, 2007;Wang et al, 2008b), cell protective activity (Elisia and Kitts, 2008;Tarozzi et al, 2007) and antitumor activity (Hou, 2003;Lala et al, 2006;Kang et al, 2003). One major anthocyanidin is cyanidin, and the effects of cyanidin and cyanin, its glycoside, have been investigated, but the biological effects of these compounds are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lines

Takeuchi

Ohtani

et al. 2011

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Anthocyanins are pigments in plants. Anthocyanins and their aglycons, anthocyanidins, have various biological effects. In the present study, we examined the effects of cyanidin and cyanidin-3-glucoside on intracellular reactive oxygen species (ROS) levels and on proliferative effects, using four cancer cell lines and one normal cell line, and we found that cyanidin (100 μmol/L) has significant effects when compared with cyanidin-3-glucoside. Cyanidin reduced intracellular ROS levels in MCF-7, HuH-7, HepG2, Caco-2 and HUVEC cell lines, but cyanidin-3-glucoside did not. Cyanidin inhibited the proliferation of MCF-7, HuH-7, HepG2 and Caco-2 cells, but cyanidin-3-glucoside did not. Cyanidin and cyanidin-3-glucoside had no effect on the proliferation of HUVEC. We also tested cyanidin-3-rutinoside, peonidin and peonidin-3-glucoside, but the presence of a sugar in their structure hampered the biological effects of aglycons. These results suggest that a sugar in the anthocyanin structure affects biological activity.

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Section: Introductionmentioning

confidence: 99%

Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lines

Takeuchi

Ohtani

et al. 2011

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“…It has been demonstrated that anthocyanins have the following physiological functions: atherogenic index-lowering effects of ruburobrassicin (cyanidin 3-sophoroside-5-monoglucoside) (Igarashi et al, 1990), serum cholesterol-lowering effect of nasunin from peel of eggplant (Kayamori & Igarashi, 1994), triacylglycerol-lowering effect of malvin (Igarashi & Inagaki, 1991), protective effects of dietary cyanidin 3-O-glucoside on liver ischemia-reperfusion injury (Tsuda et al, 1999b), promoting effect of anthocyanogen for regeneration of rhodopsin (Tronche et al, 1967), protective effect of cyanidin on oxidation of low density lipoprotein (Satue-Gracia et al, 1997), and preventive effects of nasunin and acylated anthocyanins from red cabbage on paraquat-induced oxidative stress in rats (Kimura et al, 1999;Igarashi et al, 2000). Anthocyanins are expected to have even more physiological functions which differ from those above.…”

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Protective Effects of Boysenberry Anthocyanins on Oxidative Stress in Diabetic Rats

Sugimoto

Igarashi

Kubo

et al. 2003

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The protective effects of major boysenberry anthocyanins (BoAnt) against oxidative stress were investigated in streptozotocin (STZ)-induced diabetic rats. Increases in the concentration of plasma thiobarbituric acid reactive substances (TBARS), and in the liver 8-hydroxy deoxyguanosine (8-OH dG)/deoxyguanosine (dG) ratio and also in the liver GSSG/GSH ratio, which were all observed in STZ-injected rats, were restored or tended to be restored to the level of the control rats when a diet with BoAnt was given to the diabetic animals. The susceptibility of the liver homogenate of the diabetic rats to the oxidation by AAPH was relieved when BoAnt was fed to them. These results suggested that BoAnt was effective in protecting the development of in vivo oxidation involved with diabetes.

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“…Anthocyanins are widely used as natural food colorants, and have been reported to have functional effects, such as antioxidant (Tsuda et al, 1998;Noda et al, 1998) antitumor (Koide et al, 1996;Koide et al, 1997), antimutagenicity (Yoshimoto et al, 1999), and others (Tsuda et al, 1999); they are also expected to be functional food ingredients. Research on production of secondary plant metabolites by plant cell and tissue cultures is increasing to find an effective system, or as one aspect of food biotechnology (Koda et al, 1992;Koda et al, 1993;Nawa & Ohtani, 1992).…”

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Production of Anthocyanins by Habituated Cultured Cells of Nyoho Strawberry(Fragaria ananassa Duch.).

Asano¹,

Ohtsubo²,

Nakajima³

et al. 2002

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Cultured leaf cells of Nyoho strawberry (Fragaria ananassa Duch.) produced 4 times more anthocyanins than fruit, with additions of 2.0 mg/l of 1-naphthalenacetic acid (NAA) and 0.2 mg/l of benzyladenine (BA) for 2 weeks. They were habituated after 6 passages at NAA 1.25 and BA 0.125 g/l in 107 cultures with stepwise decrease of the additions at 2-week intervals, and supervention of a gradual decrease in anthocyanin contents of 80%. They fully recovered through the following 43 passages without the additions. Finally, 3 types of cell line rich in cyanidin 3-glucoside (62%), peonidin 3-glucoside (55%) or both (49 and 36%, respectively) were obtained. They also produced pelargonidin 3-glucoside (0.6 to 1.8%), which was the main component in the fruit. The fruit produced peonidin 3-glucoside (0.4%), as well as pelargonidin 3-O-(6-O-malonyl-␤-D-glucoside) and cyanidin 3-glucoside. The habituation seems to have caused some activation or inhibition of the cell's anthocyanin formation, which originated from the mother plant.

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Protective Effects of Dietary Cyanidin 3-O-β-d-Glucoside on Liver Ischemia–Reperfusion Injury in Rats

Cited by 135 publications

References 30 publications

Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lines

Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lines

Protective Effects of Boysenberry Anthocyanins on Oxidative Stress in Diabetic Rats

Production of Anthocyanins by Habituated Cultured Cells of Nyoho Strawberry(Fragaria ananassa Duch.).

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