Protective effects of dexmedetomidine on ischaemia‐reperfusion injury in an experimental rat model of priapism

Abstract

The study aimed to investigate the effects of dexmedetomidine against ischaemia‐reperfusion injury occurring after priapism in a model of induced‐priapism in rats. A total of 18 male rats were randomised into three groups. Group 1 was the control group. A priapism model was performed rats in Group 2 and then ischaemia‐reperfusion injury was evaluated. Group 3 had similar procedures to the rats in Group 2. Rats in Group 3 additionally had 100 μg/kg dexmedetomidine administered intraperitoneally immediately after reperfusion. Blood and tissue samples were analysed. Biochemical analysis of blood samples revealed a decrease in the levels of the pro‐inflammatory cytokines including interleukin‐1 beta (IL‐1 Beta), interleukin‐6 (IL‐6), and tumour necrosis factor‐alpha (TNF‐alpha) in Group 3 compared to Group 2 (p:.04, p:.009 and p:.009, respectively). Similarly, the highest malondialdehyde (MDA) level was in Group 2 (p:.002). The levels of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) activities were significantly higher in Group 3 than that of Group 2 (p:.037 and p:.045, respectively). Direct microscopic examinations revealed positive changes in desquamation, oedema, inflammation and vasocongestion scores in Group 3 compared to Group 2 (p:.007, p:.008, p:.007 and p:.006, respectively). Dexmedetomidine has a protective effect against ischaemia‐reperfusion injury in penile tissue.

SARS-CoV-2 Infection as a Determining Factor to the Precipitation of Ischemic Priapism in a Young Patient with Asymptomatic COVID-19

“…A number of cytokines involved in the etiopathogenesis of COVID-19 have a well-known role in both inflammation and thrombosis: IL-6 in particular is linked to multiple such procoagulant pathways, purportedly through tissue factor expression on mononuclear cells [ 4 ]. Furthermore, available data heavily stresses IL-6's crucial role in COVID-19 pathophysiology [ 5 ] as well as in murine models investigating ischemic priapism [ 6 ].…”

The Effects of Dexmedetomidine on Abdominal Aortic Occlusion-Induced Ovarian Injury via Oxidative Stress and Apoptosis

“…DEX has been proven to prevent acute kidney and lung injury by inhibiting mitochondrial damage, cellular inflammation, and apoptosis [Qiu et al, 2018;Tan et al, 2018]. Kölükçü et al, 2021 revealed that DEX has a protective effect against I/R injury in penile tissue, increasing antioxidants while reducing pro-inflammatory cytokine levels. Tuglu et al [2015] reported that DEX exhibited a dosedependent antioxidant-protective effect in testicular I/R injury.…”

“…In addition, α2AR agonists can inhibit the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) (JAK/STAT) pathways [Schneider et al, 2016;Nguyen et al, 2017;Meng et al, 2018;Lankadeva et al, 2021]. DEX exhibits a protective effect against I/R injury through oxidative damage and by inducing antiapoptotic activity [Kölükçü et al, 2021]. Additionally, it exhibits anti-inflammatory and antiapoptotic effects by inhibiting both the NF-κB signaling pathway and caspase-3-related apoptosis [Sun et al, 2018].…”

“…Additionally, it exhibits anti-inflammatory and antiapoptotic effects by inhibiting both the NF-κB signaling pathway and caspase-3-related apoptosis [Sun et al, 2018]. DEX has also been shown to cause a significant decrease in the production of several cytokines, including IL-1β, TNF-α, and IL-6 [Qiu et al, 2018;Kölükçü et al, 2021;Zhao et al, 2022]. Another important feature of DEX in I/R injury is that it is a powerful antioxidant that increases GSH synthesis and regulates inflammatory enzyme activities [Kutanis et al, 2016].…”

Continuous midazolam infusion can minimize the pro-inflammatory response to anesthesia and surgery for pediatric patients with intra-abdominal infection: Comparative study versus continuous propofol infusion

“…Anesthetic drugs have discrepant effects on patients' immune milieu, desflurane alone or with NO 2 cause significant increase in systemic interleukin (IL)-6 one day after surgery [7]. On contrary, sevoflurane can attenuate the inflammatory response during cardiopulmonary bypass [8] and dexmedetomidine, in ischemia-perfusion animal model, decreased levels of IL-1β, IL-6 and tumor necrosis factor-α (TNF-α) [9].…”