Protective effects of curcumin against naproxen-induced mitochondrial dysfunction in rat kidney tissue

Aziziaram, Zahra; Bilal, Ismael; Zhong, Yuan; Mahmod, Azzadin; Roshandel, Reza

doi:10.55705/cmbr.2021.138879.1001

Cited by 21 publications

(16 citation statements)

References 27 publications

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“…There have already been reports of the biological effects of turmeric [16][17][18][19][20][21][22] .…”

Section: Results and Disscusionmentioning

confidence: 99%

Curcumin Inhibits the Growth and Induces Apoptosis of Human Endometrial Cancer Cells

Li¹

2022

IJPS

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Li: Effect of Curcumin on Human Endometrial Cancer CellsThe objective of this study was to analyze the mechanism of curcumin inhibiting the growth and inducing apoptosis of human endometrial carcinoma cell line. Human endometrial carcinoma cell line was cultured in vitro and all cells were divided into control group, curcumin low, medium and high treatment group, the concentrations were 5 mg/l, 10 mg/l and 20 mg/l, respectively. Compared with the non-medicated control group, the proliferation of human endometrial carcinoma cell treated with curcumin at different concentrations for 24, 48 and 72 h was significantly inhibited and with the increase of drug concentration, the inhibition rate was significantly increased in a dose-dependent manner (p<0.05). After treatment of human endometrial carcinoma cell with curcumin 5 mg/l, 10 mg/l and 20 mg/l, the ratio of growth 0/ growth 1 was significantly lower than that of the control group, the ratio of growth 2/mitosis phase was significantly higher than that of the control group and the ratio of growth 2/mitosis phase was gradually increased with the increase of drug concentration, which was dose-dependent (p<0.05). After treatment of human endometrial carcinoma cells with curcumin 5 mg/l, 10 mg/l and 20 mg/l, the apoptosis rate gradually increased and with the increase of drug concentration, the apoptosis rate increased sequentially (p<0.05). After treatment of human endometrial carcinoma cell with curcumin 5 mg/l, 10 mg/l and 20 mg/l, compared with the control group, the protein level of apoptosis factor Livin was significantly decreased and the protein level of caspase-3 was significantly increased in each group (p<0.05). The levels of Livin protein and caspase-3 protein were dose-dependent with curcumin concentration. It was concluded that curcumin has obvious inhibitory effect on human endometrial cancer cells and can induce cell cycle arrest, promote apoptosis, which is concentration dependent. The related reason may be through inhibiting Livin protein expression and increasing caspase-3 protein level.

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“…There have already been reports of the biological effects of turmeric [16][17][18][19][20][21][22] .…”

Section: Results and Disscusionmentioning

confidence: 99%

Curcumin Inhibits the Growth and Induces Apoptosis of Human Endometrial Cancer Cells

Li¹

2022

IJPS

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“…After 5 minutes, the mixture was acidified with 0.05 ml 7 M H 3PO 4 and injected into the HPLC system. Superoxide dismutase (SOD) enzyme activity was measured following the method described by [ 37 ]. Spectrophotometric assay of SOD was performed using 50 mM air-saturated 2-amino-2-methyl-1,3-propanediol buffer containing 3 mM boric acid and 0.1 mM diethylenetriaminepentaacetic acid at pH 8.8 and temperature 37°C.…”

Section: Methodsmentioning

confidence: 99%

The ameliorating role of sofosbuvir and daclatasvir on thioacetamide-induced kidney injury in adult albino rats

et al. 2022

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Thioacetamide (TAA) exposure and hepatitis C virus infection are usually associated with renal dysfunction. Sofosbuvir (SFV) and daclatasvir (DAC) drugs combination has great value in the treatment of hepatitis C. The study aimed to identify the nephrotoxic effects of TAA and to evaluate the ameliorative role of SFV and DAC in this condition. Forty-eight adult male albino rats were divided into eight groups and received saline (control), SFV, DAC, SFV+DAC, TAA, TAA+SFV, TAA+DAC and TAA+SFV+DAC for eight weeks. Kidney and blood samples were retrieved and processed for histological (Hematoxylin and Eosin and Masson's trichrome), immunohistochemical (α-smooth muscle actin), and biochemical analysis (urea, creatinine, total protein, albumin, malondialdehyde, reduced glutathione, superoxide dismutase, and tumor necrosis factor-α). Examination revealed marked destruction of renal tubules on exposure to TAA with either hypertrophy or atrophy of glomeruli, increase in collagen deposition, and wide expression of α-smooth muscle actin. Also, significant disturbance in kidney functions, oxidative stress markers, and tumor necrosis factor-α. Supplementation with either SFV or DAC produced mild improvement in the tissue and laboratory markers. Moreover, the combination of both drugs greatly refined the pathology induced by TAA at the cellular and laboratory levels. However, there are still significant differences when compared to the control. In conclusion, SFV and DAC combination partially but greatly ameliorated the renal damage induced by TAA which might be enhanced with further supplementations to give new hope for those with nephropathy associated with hepatitis.

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“…[2][3][4]11 Some sorts of wound healers derived from nature are octopus-inspired adhesive patches and mussel-inspired injectable hydrogel. 10,[12][13][14][15][16][17] Moreover, the extracts promote granulation, epithelialization, and collagen deposition in wound healing processes. [11][12][13][14][15][16][17] The bioactive component of Cyamopsis tetragonoloba, Lemon verbena (L. verbena), Prunus persica, Calotropis procera, Berberis lycium, Teucrium polium, Azadirachta indica, Red Ginseng, Aloe vera, and Turmeric possess antibacterial and wound treatment properties.…”

Section: Introductionmentioning

confidence: 99%

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

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Despite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.

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Protective effects of curcumin against naproxen-induced mitochondrial dysfunction in rat kidney tissue

Cited by 21 publications

References 27 publications

Curcumin Inhibits the Growth and Induces Apoptosis of Human Endometrial Cancer Cells

Curcumin Inhibits the Growth and Induces Apoptosis of Human Endometrial Cancer Cells

The ameliorating role of sofosbuvir and daclatasvir on thioacetamide-induced kidney injury in adult albino rats

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

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