Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats

Tekeli, İbrahim Ozan; Ateşşahín, Ahmet; Sakin, Fatih; Aslan, Abdullah Nabi; Çeribaşı, Songül; Yi̇pel, Mustafa

doi:10.1007/s10787-018-0485-x

Cited by 35 publications

(23 citation statements)

References 59 publications

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“…Moreover, SSZ was associated with significantly lower inflammation markers (TNF-α, IL-6, ESR, and MPO) and tissue damage. These effects of SSZ have also been previously reported in similar experimental models [46,53,56,61,62,63].…”

Section: Discussionsupporting

confidence: 83%

“…Moreover, although the protection imparted by Spirulina platensis was compared to a widely-accepted clinically-used treatment in IBD, SSZ, one important limitation of the current study is the lack of direct evidence to show the role of carotenoids, and possibly other ingredients, in the protective effects displayed by the HA extracts. However, clinical and experimental evidence by others has highlighted the importance of carotenoids in the management of gastrointestinal inflammatory conditions, including UC [19,21,28,29,61,68].…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Spirulina platensis Extract against Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Rats

et al. 2019

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Inflammatory bowel disease is a multifactorial inflammatory condition. This study aimed to test the protective effects of Spirulina platensis against ulcerative colitis (UC). UC was induced in thirty-six male Wistar rats by adding dextran sulfate sodium (DSS) to their drinking water, while a control group received only drinking water. UC rats were equally-divided into six groups that received a single oral daily dose of vehicle (DSS), sulfasalazine (SSZ, 50 mg/kg/day), chloroform or the hydroalcoholic extracts of Spirulina platensis (100 or 200 mg/kg/day) for 15 days, and then blood and colon samples were harvested for determination of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), myeloperoxidase (MPO), and histopathology. At the end of the study, compared to time-matched controls, UC rats showed increased TNF-α (1.64-fold), IL-6 (5.73-fold), ESR (3.18-fold), and MPO (1.61-fold), along with loss of body weight (24.73%) and disease activity index (1.767 ± 0.216 vs. 0 ± 0), p < 0.001. These effects were prevented by SSZ treatment (p < 0.001 vs. DSS). The hydroalcoholic extract of Spirulina platensis dose-dependently modulated all DSS-induced inflammatory changes. However, the chloroform extract significantly lowered only IL-6 and ESR, but not TNF-α or MPO levels. The protective effects of the hydroalcoholic extract of Spirulina platensis against experimental UC involved mitigation of DSS-induced inflammation.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Protective Effect of Spirulina platensis Extract against Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Rats

et al. 2019

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“…MFE was freshly prepared as a solution in distilled water (20 mg/ml). Sulfasalazine (Sulfa) was used as the reference drug, and the dose was obtained from the study of Tekeli et al (2018). Sulfa was dissolved in normal saline 0.9% to a final concentration of 10 mg/ml.…”

Section: Methodsmentioning

confidence: 99%

Protective effect ofMorus macrouraMiq. fruit extract against acetic acid-induced ulcerative colitis in rats: Involvement of miRNA-223 and TNFα/NFκB/NLRP3 inflammatory pathway

Salama

Darwish

Shaffei

et al. 2020

Preprint

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Tumor necrosis factor receptor (TNFR) activation and nuclear factor kappa B (NFκB) expression play a significant role in the activation of nod-like receptor pyrin domain-1 containing 3 (NLRP3) inflammasome inflammatory pathway, which is involved in the pathogenesis of ulcerative colitis (UC). Furthermore, miRNA-223 expression was shown to exert counter-regulatory effect on NLRP3 expression. Interestingly, polyphenols are attaining increased importance for their potential effectiveness in ameliorating certain diseases owing to their antioxidant and anti-inflammatory activity. In accord, our study attempted to investigate the effect of mulberry tree (Morus macroura) fruit extract (MFE) against acetic acid (AA)- induced UC in rats, which is not previously investigated, based on previous promising results for MFE in alleviating gastric ulcer in rats. First, total phenolic (TPC), total flavonoid (TFC), and total anthocyanin content (TAC) were determined in MFE. Then, MFE (300 mg/kg) and sulfasalazine (Sulfa), as a standard treatment (100 mg/kg), were given orally for seven days before intra-rectal induction of UC by AA (2 ml, 4% v/v) on day eight. The extent of UC was evaluated macroscopically and microscopically. Biochemically, the colonic TNFR1, NLRP3, p- NFκB p65, TNFα, interleukin-1 beta (IL-1β), IL-18 levels, miRNA-223 expression and caspase-1 activity were assayed. MFE significantly reduced macroscopic and microscopic scores, colonic levels of TNFR1, NLRP3, p-NFκB p65, TNFα, IL-1β, IL-18, and caspase-1 activity, and showed increased miRNA-223 expression, almost similarly to Sulfa effects. In conclusion, our study provided a novel impact for MFE against AA-induced UC in rats through affecting miRNA-223 expression and halting TNFα/NFκB/NLRP3 inflammatory pathway.

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“…Oxidative injure has been established to have significant serious effects on IBD pathogenesis (Sepehrimanesha et al, 2018). Acetic acid produced colon ulcer through different mechanisms including generation of oxidative stress, initiation of lipid peroxidation, inflammation, infiltration of neutrophils and induction of apoptosis (Tekeli et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Lycopene mitigates experimental colitis in rats by inhibiting oxidative stress-mediated inflammation and apoptosis

Hashem

Hussein

Senosi

2020

Benha Veterinary Medical Journal

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The potential protective and beneficial effects of Lycopene (LYC) in a rat model of acetic acid-induced ulcerative colitis (UC) were evaluated. Forty male albino rats were divided into five equal groups. Group I: (Control normal) rats received no drugs. Group II: (Early ulcerative colitis): rats received 2 ml (3% v/v) glacial acetic acid intra-colonially at 21 th day of experiment and sacrificed 3 days later. Group III:(Early ulcerative colitis + Lycopene protected) rats received Lycopene (10 mg/kg body weight/day, orally) for 21 successive days prior to acetic acid administration. Group IV: (Late ulcerative colitis) rats received acetic acid similar to group II for 3 successive days and sacrificed after 21 days. Group V: (Late ulcerative colitis+ Lycopene treated) rats first administered with acetic acid then after 3 days Lycopene was administered for 21successive days. A significant increase in L-Malondialdehyde (L-MDA) with marked decreases in reduced glutathione (GSH) level and Catalase (CAT) activity were observed in colon tissue of UC-induced rats. Additionally, a significant up-regulation of nuclear factor kappa B (NF-κB), caspase-3 and transforming growth factor-β1 (TGF-β1) and down-regulation of Interleukin-10 (IL-10) and Beta cell lymphoma-2 (Bcl-2) gene expression levels were observed in colon of UC induced rats. However, a significant depletion of colon tissue L-MDA and down-regulation of NF-κB, caspase-3 and TGF-β1 in addition to marked increases in GSH concentration and CAT activity and up-regulation of IL-10 and Bcl-2 were observed after LYC treatment. Lycopene has powerful antioxidants, anti-inflammatory and anti-apoptotic effects against ulcerative colitis.

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Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats

Cited by 35 publications

References 59 publications

Protective Effect of Spirulina platensis Extract against Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Rats

Protective Effect of Spirulina platensis Extract against Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Rats

Protective effect ofMorus macrouraMiq. fruit extract against acetic acid-induced ulcerative colitis in rats: Involvement of miRNA-223 and TNFα/NFκB/NLRP3 inflammatory pathway

Lycopene mitigates experimental colitis in rats by inhibiting oxidative stress-mediated inflammation and apoptosis

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