Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model

Hussain, Zulfia; Khan, Junaid; Arshad, Arfa; Asif, Palwasha; Rashid, Haroon; Arshad, Muhammad Imran

doi:10.1016/j.biopha.2018.11.123

Cited by 50 publications

(38 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[90] It was reported that the potential health benefits of cinnamon derived primarily from bioactive ingredients such as polyphenols and flavonoids as antioxidants [91] Pharmaceutical analyses of its essential oil revealed that cinnamaldehyde, cinnamic acid, cinnamate, procyanidins, eugenol, and catechins are the major elements of cinnamon. [92,93] The WEC and EEC had high phenolic contents of 153.5 and 205.5 GAE/g extract, respectively. A high phenolic content in any extract indicates its high antioxidant capability.…”

Section: Phenolic Compositionmentioning

confidence: 99%

Anticholinergic, antidiabetic and antioxidant activities of cinnamon ( cinnamomum verum ) bark extracts: polyphenol contents analysis by LC-MS/MS

Gülçın

Kaya

Gören

et al. 2019

International Journal of Food Properties

View full text Add to dashboard Cite

Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum)were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. Their inhibitory effects were tested against some enzymes including acetylcholinesterase, butyrylcholinesterase, α-glycosidase and αamylase, which linked to different diseases. Additionally, the antioxidant properties were determined and polyphenolic compositions of the both extracts were evaluated by LC-MS/MS analysis. According to the LC-MS/MS experiments, thirteen compounds were found in WEC and EEC. Also, p-hydroxybenzoic acid (321.1 mg/kg extract), p-coumaric acid (291.4 mg/kg extract), and pyrogallol (142.4 mg/kg extract) were found to be the most abundant ingredients in the WEC. On the other hand, pyrogallol (264.3 mg/kg extract), ferulic acid (224.7 mg/ kg extract) and p-coumaric acid (170.2 mg/kg extract) were found as the most plentiful chemicals in the EEC. For the estimation of the antioxidant capacities of the both extracts (WEC and EEC), DPPH· and ABTS •+ scavenging activities, as well as Fe 3+ -Fe 2+ , and Cu 2+ -Cu + reducing assays were studied. The IC 50 values of the WEC and EEC indicated that they were potent effective DPPH· (21. 25 and 15.71 μg/mL) and ABTS •+ (6.52 and 5.79 μg/mL) scavengers, as well as AChE (221.33 and 110.26 μg/mL), BChE (461.69 and 94.93 μg/mL), α-glycosidase (206.86 and 220.00 μg/mL) and α-amylase (189.86 and 200.86 μg/mL) inhibitors. As a conclusion, both EEC and WEC had rich phenolic contents and demonstrated effective anticholinergic, antidiabetic and antioxidant effects. ARTICLE HISTORY

show abstract

Section: Phenolic Compositionmentioning

confidence: 99%

Anticholinergic, antidiabetic and antioxidant activities of cinnamon ( cinnamomum verum ) bark extracts: polyphenol contents analysis by LC-MS/MS

Gülçın

Kaya

Gören

et al. 2019

International Journal of Food Properties

View full text Add to dashboard Cite

show abstract

“…Apart from its delicious taste and flavouring of the food, it has been an effective remedy against many ailments since ancient times. The studies have revealed that the use of cinnamon helps in controlling blood glucose level and it has protective effects against oxidative stresses [8,9]. Along with the beneficial effects of the cinnamon, there are no toxic and side effects associated with the use of cinnamon.…”

Section: Discussionmentioning

confidence: 99%

The evaluation of toxicological effects of cinnamon nanoparticles by histopathological examination

2020

Ann Clin Anal Med

View full text Add to dashboard Cite

Aim: The aim of the present study is to assess the potential toxic effects of the different doses of nanoparticles of cinnamon on the liver and kidney of mice . Materials and Methods: After the preparation of nanoparticles of cinnamon, the three experimental groups (A1, A2, and A3) of the animals were fed 5 ppm, 10 ppm, and 20 ppm respectively while the control group (B) was not exposed to cinnamon nanoparticles. Each group of animals contains six BALB/c mice. Liver and kidney tissue samples from the experimental groups and control group were evaluated for possible toxicological effects by histopathological examination. Results: The histological examination of liver revealed mild inflammation in Group A3 that was fed 20ppm of nanoparticles of cinnamon while the other experimental groups (A1, A2) and control group showed no morphological evidence of toxic effects. The histopathological assessment of kidneys specimen of the animals from the experimental Group A3 showed vacuolization in the tubules while no morphological alterations were seen in other experimental groups and the control group. Discussion: Cinnamon nanoparticles showed some histological evidence of toxic effects in the liver and kidney of rats with their higher dosage.

show abstract

“…These particular states are characterized by an upregulated production of inflammatory mediators, alteration of vascular responses, and inflammatory cell infiltration. 74,75 Therefore, the use of natural products with anti-inflammatory activity, such as cinnamon essential oil, 76,77 to alleviate the negative effects of UVB radiation could be of high interest.…”

Section: In Vivo Efficacy Of the Fibrous Dressingsmentioning

confidence: 99%

Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care

et al. 2020

View full text Add to dashboard Cite

show abstract

Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model

Cited by 50 publications

References 36 publications

Anticholinergic, antidiabetic and antioxidant activities of cinnamon ( cinnamomum verum ) bark extracts: polyphenol contents analysis by LC-MS/MS

Anticholinergic, antidiabetic and antioxidant activities of cinnamon ( cinnamomum verum ) bark extracts: polyphenol contents analysis by LC-MS/MS

The evaluation of toxicological effects of cinnamon nanoparticles by histopathological examination

Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care

Contact Info

Product

Resources

About