The evaluation of toxicological effects of cinnamon nanoparticles by histopathological examination

Abstract

Aim: The aim of the present study is to assess the potential toxic effects of the different doses of nanoparticles of cinnamon on the liver and kidney of mice . Materials and Methods: After the preparation of nanoparticles of cinnamon, the three experimental groups (A1, A2, and A3) of the animals were fed 5 ppm, 10 ppm, and 20 ppm respectively while the control group (B) was not exposed to cinnamon nanoparticles. Each group of animals contains six BALB/c mice. Liver and kidney tissue samples from the experimental groups and control group were evaluated for possible toxicological effects by histopathological examination. Results: The histological examination of liver revealed mild inflammation in Group A3 that was fed 20ppm of nanoparticles of cinnamon while the other experimental groups (A1, A2) and control group showed no morphological evidence of toxic effects. The histopathological assessment of kidneys specimen of the animals from the experimental Group A3 showed vacuolization in the tubules while no morphological alterations were seen in other experimental groups and the control group. Discussion: Cinnamon nanoparticles showed some histological evidence of toxic effects in the liver and kidney of rats with their higher dosage.