Protective effects of cerium oxide and yttrium oxide nanoparticles on reduction of oxidative stress induced by sub-acute exposure to diazinon in the rat pancreas

Khaksar, Mohammad Reza; Rahimifard, Mahban; Baeeri, Maryam; Maqbool, Faheem; Navaei-Nigjeh, Mona; Hassani, Shokoufeh; Moeini-Nodeh, Shermineh; Kebriaeezadeh, Abbas; Abdollahi, Mohammad

doi:10.1016/j.jtemb.2017.02.013

Cited by 63 publications

(31 citation statements)

References 61 publications

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“…In a pilot study, NC induced severe toxicity at a dose of 5 mg/kg for 7 days. While Khaksar et al (32) showed that NC (35 mg/kg daily for 2 weeks) has a protective effect against diazinon-induced pancreatic damage. They also showed that NC decreases oxidative stress and apoptosis (caspase 3 and 9).…”

Section: Discussionmentioning

confidence: 97%

Anti-apoptotic and Antioxidant Effect of Cerium Oxide Nanoparticles on Cyclophosphamide-Induced Hepatotoxicity

Amiri¹,

Hamzeh²,

Beklar³

et al. 2018

Erciyes Med J

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Objective: Cyclophosphamide (CP), as an anticancer agent has side effects, especially hepatotoxicity. Cerium oxide nanoparticles [nanoceria (NC)], which act as antioxidants, have a protective effect against oxidative stress-induced toxicity. This study evaluated the preventive effect of NC in hepatotoxicity induced by CP. Materials and Methods: Thirty-two mice were randomly distributed into four groups: control (received only normal saline), NC (received NC 100 μg/kg for 3 days, intraperitoneally), CP (received CP 200 mg/kg single dose on the third day of the study, intraperitoneally), and NC+CP (NC 100 μg/kg and CP 200 mg/kg). Two days after the final treatment, oxidative stress marker (MDA and GSH) and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels were measured, and histopathological and immunohistochemical examinations were performed for determining the effects of NC on hepatotoxicity. Results: CP-induced hepatotoxicity was evident by the significant elevation of liver enzyme levels and alteration in oxidative stress marker levels. Additionally, histopathological changes and apoptosis were markedly increased. NC decreased MDA level, increased GSH level and decreased liver enzyme levels in CP-treated mice. In addition, NC pretreatment could be alleviated by the immunoreactivity of caspase-3 in CP-treated mice compared with the CP group. Conclusion: NC showed a potent antioxidant effect in hepatotoxicity induced by CP. The study suggested that NC through its antioxidant and anti-apoptotic properties has a protective effect against hepatotoxicity induced by CP.

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Section: Discussionmentioning

confidence: 97%

Anti-apoptotic and Antioxidant Effect of Cerium Oxide Nanoparticles on Cyclophosphamide-Induced Hepatotoxicity

Amiri¹,

Hamzeh²,

Beklar³

et al. 2018

Erciyes Med J

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“…During the execution of apoptosis cleaved caspase 3 is responsible, either partly or totally, for the proteolytic cleavage of a large number of proteins and for apoptosis associated chromatin margination, DNA fragmentation and nuclear collapse during apoptosis [22] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Orlistat on the pancreas of the female albino rat: Histological and Histochemical study

Abdelwahab

Ali

Mahmoud

2017

Journal of Medical Histology

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Introduction: Orlistat is the only FDA approved drug for long term management of obesity. It reduces the absorption of dietary fat by inhibiting lipase enzyme. Many cases of pancreatitis were clinically reported in people who used orlistat. Aim of The work:The aim of the present study is to shed a light on the possible deleterious effect of orlistat on the normal pancreatic tissue, and the molecular mechanisms beyond these changes. Materials & Methods: Thirty six female albino rats were divided into 4 groups: Control Group I (a) without treatment &I (b) received only1 ml fish oil. Group II received 30 mg/kg/day of orlistat dissolved in 1ml of fish oil orally for 8 weeks. Group III, received 40 mg/kg/day of orlistat .Group IV (a) & (b) withdrawal groups. Pancreas was dissected out and processed for histological and immunohistochemical study for CASPASE, TNF, INOS and INSULIN. Results: Orlistat caused variable degrees of pancreatic tissue degeneration, dilatation of pancreatic ducts with retained secretion, fatty degeneration and congestion. Inflammatory cells infiltration observed in both pancreatic acini and islets of Langerhan,s only with high dose (40mg/kg). Positive immunoreactivity for activated caspase 3 and iNOS being more evident in high dose and decrease in immunoreactivity for anti-insulin antibody. immunoreactivity for TNF-α had been shown in high dose. These effects disappear after low dose withdrawal only. Conclusion: Orlistat may induce inflammation, fatty degeneration and impaired insulin production in the pancreas. These effects are dose dependent, and it should be taken in consideration while prescribing orlistat as a treatment for obesity.

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“…This study, therefore, reports a comparative finding in terms of surface reactivity and biocompatibility of Y 2 O 3 NPs with the chemically related NPs of CeO 2 and chemically un-related NPs of ZnO. It is notable that NPs of Y 2 O 3 , like that of CeO 2 NPs, have been reported to be antioxidant and protective in cells of neural [18,19] and retinal [20], whereas some investigators have reported this NP as oxidative and toxic [21,22]. In this study, we have provided a comparative data on surface reactivity with BSA and media components which is not known.…”

Section: Introductionmentioning

confidence: 84%

“…In mouse normal hepatocyte cell line, Y 2 O 3 NPs (7-8 nm) coated with polymer of acrylic acid have been reported to cause toxicity at the concentration of 10 µg/mL [21]. On the other hand, NPs of Y 2 O 3 have been reported to be antioxidant and protective in cells of neural [18,19] and retinal [20] origin. In this study, no significant difference in cell viability was observed for BSA-coated and native NPs of Y 2 O 3 (See Figure S1).…”

Section: Discussionmentioning

confidence: 99%

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High Surface Reactivity and Biocompatibility of Y2O3 NPs in Human MCF-7 Epithelial and HT-1080 Fibro-Blast Cells

et al. 2020

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This study aimed to generate a comparative data on biological response of yttrium oxide nanoparticles (Y2O3 NPs) with the antioxidant CeO2 NPs and pro-oxidant ZnO NPs. Sizes of Y2O3 NPs were found to be in the range of 35±10 nm as measured by TEM and were larger from its hydrodynamic sizes in water (1004 ± 134 nm), PBS (3373 ± 249 nm), serum free culture media (1735 ± 305 nm) and complete culture media (542 ± 108 nm). Surface reactivity of Y2O3 NPs with bovine serum albumin (BSA) was found significantly higher than for CeO2 and ZnO NPs. The displacement studies clearly suggested that adsorption to either BSA, filtered serum or serum free media was quite stable, and was dependent on whichever component interacted first with the Y2O3 NPs. Enzyme mimetic activity, like that of CeO2 NPs, was not detected for the NPs of Y2O3 or ZnO. Cell viability measured by MTT and neutral red uptake (NRU) assays suggested Y2O3 NPs were not toxic in human breast carcinoma MCF-7 and fibroblast HT-1080 cells up to the concentration of 200 μg/mL for a 24 h treatment period. Oxidative stress markers suggested Y2O3 NPs to be tolerably non-oxidative and biocompatible. Moreover, mitochondrial potential determined by JC-1 as well as lysosomal activity determined by lysotracker (LTR) remained un-affected and intact due to Y2O3 and CeO2 NPs whereas, as expected, were significantly induced by ZnO NPs. Hoechst-PI dual staining clearly suggested apoptotic potential of only ZnO NPs. With high surface reactivity and biocompatibility, NPs of Y2O3 could be a promising agent in the field of nanomedicine.

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Protective effects of cerium oxide and yttrium oxide nanoparticles on reduction of oxidative stress induced by sub-acute exposure to diazinon in the rat pancreas

Cited by 63 publications

References 61 publications

Anti-apoptotic and Antioxidant Effect of Cerium Oxide Nanoparticles on Cyclophosphamide-Induced Hepatotoxicity

Anti-apoptotic and Antioxidant Effect of Cerium Oxide Nanoparticles on Cyclophosphamide-Induced Hepatotoxicity

Effect of Orlistat on the pancreas of the female albino rat: Histological and Histochemical study

High Surface Reactivity and Biocompatibility of Y2O3 NPs in Human MCF-7 Epithelial and HT-1080 Fibro-Blast Cells

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