Protective Effects of Antioxidants in Huntington’s Disease: an Extensive Review

Essa, Musthafa Mohamed; Moghadas, Marzieh; Ba-Omar, Taher; Qoronfleh, M. Walid; Guillemin, Gilles J.; Manivasagam, Thamilarasan; Justin-Thenmozhi, Arokiasamy; Ray, Bipul; Bhat, Abid; Chidambaram, Saravana Babu; Fernandes, Amanda J.; Song, Byoung Joon; Akbar, Mohammed

doi:10.1007/s12640-018-9989-9

Cited by 52 publications

(33 citation statements)

References 286 publications

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“…Current therapeutic methods against HD are mostly based on attenuating disease symptoms . The reported cases include tetrabenazine, antioxidants, and antidepressants . On the other hand, others developed a preventive strategy by using an inhibitor or presymptomatic intervention.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Inhibitor Based on Chitosan and Amphiphilic Peptide against Mutant Huntingtin Toxicity

Wahyuningtyas

Chen

et al. 2019

ChemBioChem

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Huntington's disease (HD) is classified as a protein‐misfolding disease correlated with the mutant Huntingtin (mHtt) protein with abnormally expanded polyglutamine (polyQ) domains. Because no effective drugs have yet been reported, attempts to develop better therapy to delay the age of onset are in urgent demand. In this study, an amphiphilic peptide consisting of negatively charged hexaglutamic acid and a stretch of decaglutamine (E6Q10) was chemically synthesized as an inhibitor against polyQ and mHtt toxicity. It is found that E6Q10 selfassembles into spherical vesicles, as shown by means of TEM, cryoelectron microscopy, and dynamic light scattering. Assembled E6Q10 prevented the polyQ‐rich peptide (KKWQ20AKK) from forming amyloid fibrils. To enable the cell‐penetration ability of E6Q10, the E6Q10⋅chitosan complex was generated. It is demonstrated that the complex penetrates cells, interferes with the mHtt oligomerization and aggregation process, and prevents mHtt cytotoxicity. By combining positively charged chitosan and amphiphilic peptides with a negatively charge moiety, a new strategy is provided to develop biocompatible and biodegradable inhibitors against mHtt toxicity.

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Section: Introductionmentioning

confidence: 99%

Biocompatible Inhibitor Based on Chitosan and Amphiphilic Peptide against Mutant Huntingtin Toxicity

Wahyuningtyas

Chen

et al. 2019

ChemBioChem

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“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by abnormally increased intracellular accumulation of the Huntingtin (Htt) protein due to repetition polyglutamine (polyQ) repeats which in turn produces inclusion bodies (IBs) and leading to the development of motor disabilities in HD patients. Common symptoms include involuntary movements, abnormalities in gait, posture, and balance, obsessive–compulsive behavior, and memory loss .…”

Section: Curcumin In Neurodegenerative Diseasesmentioning

confidence: 99%

Benefits of curcumin in brain disorders

et al. 2019

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Curcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti‐inflammatory, anti‐cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This review summarizes available data from several recent studies on curcumin in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Huntington's disease, Prions disease, stroke, Down's syndrome, autism, Amyotrophic lateral sclerosis, anxiety, depression, and aging. Recent advancements toward increasing the therapeutic efficacy of curcuma/curcumin formulation and the novel delivery strategies employed to overcome its minimal bioavailability and toxicity studies have also been discussed. This review also summarizes the ongoing clinical trials on curcumin for different neurodegenerative diseases and patent details of curcuma/curcumin in India.

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“…Sustained oxidative stress, in particular, ROS may also trigger abnormalities in mitochondrial function, impairment of the DNA repair system, and cellular damage, all of which are considered to play decisive roles in accelerating the aging process and the development of neurodegenerative disorders [37,38]. Indeed, a large body of evidence exists underscoring the role of ROS in several human disease states, including neurodegenerative disorders [39][40][41][42]. Therefore, continued efforts are critical to identifying agents that could be potentially useful in the treatment and prevention of neurodegenerative diseases [7,43].…”

Section: Oxidative Stress and Neurodegenerative Disordersmentioning

confidence: 99%

“…Therefore, continued efforts are critical to identifying agents that could be potentially useful in the treatment and prevention of neurodegenerative diseases [7,43]. Many studies have observed the association between the accumulation of ROS and the pathogenesis of neurodegenerative disorders, including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's diseases [39][40][41]44]. In brief, Alzheimer's disease is a neurodegenerative disorder that is characterized by the progressive loss of memory and the development of dementia [45,46], whereas Huntington's disease refers to a hereditary disorder of the CNS [40,42].…”

Section: Oxidative Stress and Neurodegenerative Disordersmentioning

confidence: 99%

“…Many studies have observed the association between the accumulation of ROS and the pathogenesis of neurodegenerative disorders, including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's diseases [39][40][41]44]. In brief, Alzheimer's disease is a neurodegenerative disorder that is characterized by the progressive loss of memory and the development of dementia [45,46], whereas Huntington's disease refers to a hereditary disorder of the CNS [40,42]. The symptoms of Huntington's disease include cognitive impairments, movement disorders, and psychiatric disorders [47].…”

Section: Oxidative Stress and Neurodegenerative Disordersmentioning

confidence: 99%

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Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Madireddy¹,

Madireddy²

2019

J Neurosci Neurol Disord

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Vitamin E Antioxidant, Neuroprotection Vitamin E is a scavenger of several ROS and serves to reduce their reactivity and toxicity. It offers protection from the propagative damage of ROS by inhibiting the oxidative modifi cation of lipoproteins AD [74-79,82-86] PD [175-177,79] ALS [193,217,218] Vitamin C Antioxidant, Neuroprotection Vitamin C is an excellent antioxidant, suitable in reducing ROS levels, lipid peroxidation, and oxidative stress. It is also useful in regenerating other antioxidants. AD [81,82,75,77,79] PD [166-168] ALS [213,214] Vitamin D Antioxidant Neuroprotection Vitamin D prevent oxidative stress, lower the production of free radicals, and reduce neurotoxicity through the enhancement of autophagy signaling pathways AD [74-78,30,16,80] PD [157-159,169-174] ALS [215,216] Vitamin A Antioxidan Vitamin A prevent the formation of Aβ plaques AD [16,30,74-78] Vitamin B Antioxidant Neuroprotection Vitamin B perform antioxidant and neuroprotective functions AD [88-90] PD [157-159,162-165] HD [105] Curcumin Antioxidant Anti-infl ammatory Neuroprotection Curcumin is a scavenger of free radicals and reduces mitochondrial disfunction. AD [100,101] Omega−3 fatty acids Antioxidant Anti-infl ammatory Omega-3 fatty acids reduce ROS formation acting as free radical scavengers.

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Protective Effects of Antioxidants in Huntington’s Disease: an Extensive Review

Cited by 52 publications

References 286 publications

Biocompatible Inhibitor Based on Chitosan and Amphiphilic Peptide against Mutant Huntingtin Toxicity

Biocompatible Inhibitor Based on Chitosan and Amphiphilic Peptide against Mutant Huntingtin Toxicity

Benefits of curcumin in brain disorders

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

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