Protective effects of allicin on streptozotocin‐induced diabetic nephropathy in rats

Huang, Hong; Jiang, Ying; Mao, Genxiang; Fang, Yuan; Zheng, Hao; Ruan, Yuan; Wu, Tianfeng

doi:10.1002/jsfa.7874

Cited by 34 publications

(54 citation statements)

References 30 publications

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“…10 The use of antioxidants to combat the harmful effects of oxidative stress in diabetic nephropathy has been reported in a number of experimental models. For example, extract from ginkgo biloba and allicin improved glomerular hypertrophy in diabetic rats, 11 , 12 and administration of Lindera strychnifolia decreased the development of diabetic nephropathy in mice. 13 In addition, rosmarinic acid, aster koraiensis, vitamin C, alpha lipoic acid, ferulic acid and coenzyme Q10 have been shown to treat glomerulosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Comparing the renoprotective effects of the antioxidants melatonin, vitamin D and vitamin E in diabetic rats

Alqasim

Eldin

Hammadi

et al. 2020

Journal of Taibah University Medical Sciences

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Objectives Diabetes mellitus is associated with oxidative stress that leads to inflammation and diabetic nephropathy. This study aimed to determine the possible renoprotective effects of the antioxidants melatonin, vitamin D and vitamin E in diabetic rats. Methods We divided 108 albino rats into 12 groups. G1 group was fed a normal diet and did not receive any medication. G2 to G4 consisted of non-diabetic rats that were treated as follows: G2 with melatonin; G3 with vitamin E; G4 with vitamin D. Groups G5 to G12 consisted of diabetic rats that were treated as follows: G5 received no medication; G6 treated with insulin; G7 treated with melatonin; G8 treated with melatonin and insulin; G9 treated with vitamin E; G10 treated with vitamin E and insulin; G11 treated with vitamin D and G12 treated with vitamin D and insulin. Two months after treatment commenced, histological and biochemical examinations of glucose profile, oxidative stress status, renal function, homocysteine and TNF-α were performed. Results Total antioxidant capacity (TAC) increased significantly in groups G2, 7, 8, 10 and 11. TNF-α significantly increased in G2, but decreased in all other groups. Creatinine increased significantly in groups G5, 6, 7, 8, 9, 11 and 12. In the kidneys of the diabetic rats, thickened capillary basement membrane, diffuse mesangial sclerosis and nodular glomerulosclerosis was observed. Rats treated with melatonin showed marked improvement in these symptoms. However, in those treated with vitamin D and E, thickened capillary basement membrane and mesangial sclerosis was still present. Conclusions Melatonin, administered either with or without insulin had a significant biochemical antioxidant effect and histological renoprotective effect. Conversely, vitamin D and E did not appear to have any effects on the parameters measured.

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Section: Introductionmentioning

confidence: 99%

Comparing the renoprotective effects of the antioxidants melatonin, vitamin D and vitamin E in diabetic rats

Alqasim

Eldin

Hammadi

et al. 2020

Journal of Taibah University Medical Sciences

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“…Diallyl thiosulfinate (allicin) is a major component formed when garlic ( Allium sativum ) is crushed or ground [ 8 ]. Allicin is considered as a panacea as it has a broad spectrum of physiological activities such as antihypertensives [ 9 , 10 ], antioxidants [ 9 ], antidiabetics [ 11 ], cardioprotectives [ 10 ], nephroprotectives [ 11 ], and immunomodulators [ 12 , 13 ]. As far as nephroprotective mechanisms of allicin in experimental DN are concerned, recent studies have shown that this garlic derivative partially reverses the increased expression of transforming growth factor β (TGF-β) and the activation (i.e., phosphorylation) of its downstream target extracellular signal-regulated kinase ½ (ERK1/2) that drive renal epithelial-mesenchymal transition and fibrosis [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of the Nutraceutical Garlic Derivative Allicin in the Progression of Diabetic Nephropathy

Buendía

González

Reyes

et al. 2018

IJMS

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Diabetic nephropathy (DN) is presently the primary cause of chronic kidney disease and end-stage renal disease (ESRD). It has been suggested that inflammation and oxidative stress, in addition to or in concert with the metabolic changes, plays an important role in the maintenance and progression of the disease. Therefore, attenuating or blocking these mechanisms may be a therapeutic target to delay the progression of the disease. Diallyl thiosulfinate (allicin), a compound derived from garlic, inhibits free radical formation, increases glutathione synthesis and decreases the levels of proinflammatory molecules in vitro. This research aimed to assess the effect of allicin on oxidative stress and inflammation-induced diabetes. Animals were divided into control and diabetes (streptozotocin 50 mg/kg i.p.), and maintained for 30 days. After 30 days, the group of diabetic animals was subdivided into diabetes and allicin-treated diabetes (16 mg/kg/day oral gavage). The three experimental groups were maintained for another month. We analyzed the status of renal function, oxidative stress and proinflammatory cytokines. The untreated diabetic group showed hyperglycemia and increased diuresis, creatinine clearance, proteinuria, glycosuria and urinary excretion of N-acetyl-β-d-glucosaminidase (NAG), as well as increased oxidative stress and the expression of interleukin 1β (IL-1β), IL-6, nuclear factor kappa beta (NFκβ) and transforming growth factor-β1 (TGF-β1) in plasma and kidney. In contrast, the inhibitor of NFκβ (Iκβ) is decreased in the cortex. It has been demonstrated that the allicin treatment decreases hyperglycemia, polyuria, and NAG excretion. The oxidative stress and proinflammatory cytokines were also reduced by the allicin treatment. In conclusion, allicin delays the progression of diabetic nephropathy through antioxidant and anti-inflammatory mechanisms.

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“…Allicin is isolated from garlic and may also be extracted as a brownish orange dry resin from the Garcinia hanburyi tree occurring in South-East Asia (11,12). In previous years, Asians have used allicin as a traditional medicine for the therapy of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer

Xiang

Zhao

et al. 2018

Exp Ther Med

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Abstract. Allicin has been reported to inhibit cancer cell proliferation, induce cell apoptosis and enhance the accumulation of reactive oxygen species. However, it has remained elusive whether allicin improves multidrug resistance in thyroid cancer cells through modulating autophagy. The present study demonstrated that combined use of allicin and cisplatin or carboplatin resulted in an enhanced growth inhibitory effect on SW1736 and HTh-7 cells. Furthermore, treatment with allicin significantly increased SW1736 and HTh-7 cell autophagy. Of note, allicin-induced cell death was largely abolished by 3-methyladenine or chloroquine treatment, suggesting that allicin-induced A549 cell death was dependent on autophagy. Western blot analysis demonstrated that allicin treatment inhibited the activation of Akt, mammalian target of rapamycin and S6. Furthermore, it was demonstrated that combined use of allicin and rapamycin induced more cell death compared with that induced by allicin or rapamycin alone. In conclusion, allicin may serve as an adjunctive therapy for thyroid cancer, as it induces autophagy-dependent cell death even when cancer cells have developed apoptosis resistance.

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Protective effects of allicin on streptozotocin‐induced diabetic nephropathy in rats

Abstract: These results suggested that allicin may play a protective role in diabetic nephropathy via the TGF-β1/ERK pathway in diabetic rats. © 2016 Society of Chemical Industry.

Cited by 34 publications

References 30 publications

Comparing the renoprotective effects of the antioxidants melatonin, vitamin D and vitamin E in diabetic rats

Comparing the renoprotective effects of the antioxidants melatonin, vitamin D and vitamin E in diabetic rats

Immunomodulatory Effects of the Nutraceutical Garlic Derivative Allicin in the Progression of Diabetic Nephropathy

Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer

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