Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer

Xiang, Yangfeng; Zhao, Jian‐Qiang; Zhao, Ming; Wang, Kejing

doi:10.3892/etm.2018.5828

Cited by 26 publications

(22 citation statements)

References 31 publications

(38 reference statements)

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“…In this study, the acute effect of 24h exposure to single-agent treatment and co-treatment was investigated, based on the 24h IC 50 , in accordance with other research papers that have previously been published by other research groups [40,41]. Allicin 24h treatment was shown to be efficient in lung, breast, and colon cancer [42], and thyroid cancer [43]. Allicin can inhibit cell the migration and proliferation of lung adenocarcinoma after 24h treatment [40,44].…”

Section: Discussionmentioning

confidence: 77%

The Synergistic Antitumor Effect of 5-Fluorouracil Combined with Allicin against Lung and Colorectal Carcinoma Cells

et al. 2020

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5-fluorouracil (5-FU) is an anticancer drug used to inhibit the proliferation of many different tumor cells. Since severe events are associated with this compound, its combination with different anticancer drugs or adjuvants would allow the use of a significantly lower dose of 5-FU. In this study, we highlighted that the combination of allicin with 5-FU inhibited the cell migration and proliferation of colorectal and lung cancer cells. 5-FU inhibited cell growth with a similar inhibitory concentration for both normal and tumor cells (~200µM), while allicin showed different inhibitory concentrations. With an IC50 of 8.625 µM, lung cancer cells were the most sensitive to allicin. Compared to 5-FU and allicin single-agent treatments, the co-treatment showed a reduced viability rate, with p < 0.05. The morphological changes were visible on all three cell lines, indicating that the treatment inhibited the proliferation of both normal and tumor cells. We highlighted different cell death mechanisms—apoptosis for lung cancer and a non-apoptotic cell death for colorectal cancer. The synergistic antitumor effect of 5-FU combined with allicin was visible against lung and colorectal carcinoma cells. Better results were obtained when a lower concentration of 5-FU was combined with allicin than the single-agent treatment at IC50.

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Section: Discussionmentioning

confidence: 77%

The Synergistic Antitumor Effect of 5-Fluorouracil Combined with Allicin against Lung and Colorectal Carcinoma Cells

et al. 2020

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“…Allicin, a compound that is generated when garlic cloves are crushed or cut, has diverse biological activities, including anticancer and anti-inflammatory properties (Bayan, Koulivand & Gorji, 2014;Ginter & Simko, 2010;Lin et al, 2017). Several studies have shown that allicin causes apoptosis or autophagy in several types of cancer cell through the p53 pathway (Chu et al, 2012(Chu et al, , 2013Li, Jing, Ma & Liang, 2018;Oommen, Anti, Srinivas & Karunagaran, 2004;Xiang, Zhao, Zhao & Wang, 2018). By contrast, during in vitro maturation of porcine oocyte, allicin prevents apoptosis by regulating expression of Bcl family genes (Jeong et al, 2017).…”

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confidence: 99%

Allicin protects porcine oocytes against damage during aging in vitro

Park

Lee

Yoon

et al. 2019

Molecular Reproduction Devel

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Allicin, a chemical component of garlic, has strong antioxidant activity and is thought to exert antiaging effects in vitro. We investigated whether allicin treatment would protect porcine oocytes and embryos from postovulatory aging mediated by apoptosis and autophagy. The rates of oocyte survival and polar body extrusion in samples treated with 1 µM allicin (1 AL) were significantly higher than in untreated samples (0 AL). In addition, 1 AL prevented defects in spindle formation and chromosome alignment, as well as decreases in the expression of maturation markers, during in vitro aging. In this study, we considered allicin to be a regulator of autophagy rather than an antioxidant or antiapoptotic agent. At the embryo level, although the cleavage rate after parthenogenetic activation was similar in all groups, the blastocyst formation rate was higher in the 1 AL group than in the 0 AL group. Our findings demonstrate that allicin effectively prevents the deterioration of porcine oocytes during aging in vitro, and could therefore be used to improve the quality of aged oocytes used in in vitro experiments.

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“…Allicin inhibits the proliferation of cancer cells, induces cell apoptosis, and increases the intracellular levels of ROS [57,118]. It can also improve multidrug resistance in thyroid cancer cells via inducing autophagy but inactivating AKT and S6 pathways [119].…”

Section: Other Bioactivitiesmentioning

confidence: 99%

Herbal Active Ingredients: An Emerging Potential for the Prevention and Treatment of Papillary Thyroid Carcinoma

Yang

Chen

et al. 2020

BioMed Research International

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Papillary thyroid carcinoma (PTC) is the most common subtype of differentiated thyroid cancers in Asian coastal cities, where the patients have increased risk of potentially high or excessive iodine intake. Given the high metastasis and recurrence of patients with BRAFV600E mutation, the mortality rate of thyroid cancer has recently shown an upward trend. A variety of therapies, including surgery, radiotherapy, and chemotherapy, have been used to treat thyroid cancer, but these therapies still have limitations, including postoperative complications, drug resistance, poor efficacy, or serious side effects. Recent studies have shown the potential of active ingredients derived from herbal medicine in inhibiting PTC via various cell signaling pathways. Some plant-derived compounds, such as apigenin, genistein, and curcumin, are also known to prevent and treat PTC. This article summarizes the recent advances in the structure-functional impact of anti-PTC active ingredients and their effects on PTC cells and tumor microenvironments with an emphasis on their challenges from basic research to clinical practice.

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Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer

Cited by 26 publications

References 31 publications

The Synergistic Antitumor Effect of 5-Fluorouracil Combined with Allicin against Lung and Colorectal Carcinoma Cells

The Synergistic Antitumor Effect of 5-Fluorouracil Combined with Allicin against Lung and Colorectal Carcinoma Cells

Allicin protects porcine oocytes against damage during aging in vitro

Herbal Active Ingredients: An Emerging Potential for the Prevention and Treatment of Papillary Thyroid Carcinoma

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