“…There is report of increase in different innate immune system upon administration/intake of probiotics i.e. In tilapia (Oreochromis niloticus) a two weeks feeding of Lactobacillus rhamnosus significantly stimulates phagocytosis (Pirarat et al, 2006), Stimulation of lysozyme activity in rainbow trout was observed after two weeks feeding with Kocuria sp. SM1 (Sharifuzzaman and Austin, 2009) and Carnobacterium divergens B33 (Sakai et al, 1995), Probiotics such as L. rhamnosus, E. faecium and B. subtilis are found to up regulate the proinflammatory cytokines such as IL-1b1 and TGF b in the spleen and head kidney of the O. mykiss (Panigrahi et al, 2007), Sharifuzzaman and Austin(2009) also reported significantly higher anti-protease activity in O. mykiss within two weeks of the completion of probiotic species Kocuria.…”