Protective Effects and Mechanism of Polysaccharides from Edible Medicinal Plants in Alcoholic Liver Injury: A Review

Su, Zhuo-Wen; Yan, Ting-Yu; Feng, Jing; Zhang, Meng-Yuan; Han, Lei; Zhang, Hua-Feng; Xiao, Ying

doi:10.3390/ijms242216530

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…Typically, mitochondrial abnormalities usually occur in the early stages of alcoholic liver injury that continually produce detrimental effects on hepatocytes. When the liver is chronically exposed to ethanol, mitochondria produce large amounts of reactive nitrogen species (RNS) and ROS, which inactivate components of the respiratory chain by destroying mitochondrial DNA (mtDNA), inducing mitochondrial permeability transition, leading to mitochondrial swelling and rupture, and ultimately hepatocyte death ( Su et al, 2023 ). ROS secreted by mitochondria is scavenged by the cellular antioxidant system.…”

Section: Pathophysiology Of Aldmentioning

confidence: 99%

“…However, overproduction of ROS due to excessive alcohol consumption may disturb the balance. Subsequently, oxidative stress may become an essential factor in alcoholic liver injury ( Su et al, 2023 ). Oxidative stress is characterized by an increase in lipid peroxidation associated with alterations in the antioxidant system ( Molina et al, 2003 ).…”

Section: Mechanism Of Action Of Hovenia Dulcis In the Treatment Of Al...mentioning

confidence: 99%

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Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease

He,

Liu,

Wang

et al. 2024

Front. Pharmacol.

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Globally, alcohol-associated liver disease (ALD) has become an increased burden for society. Disulfirams, Benzodiazepines (BZDs), and corticosteroids are commonly used to treat ALD. However, the occurrence of side effects such as hepatotoxicity and dependence, impedes the achievement of desirable and optimal therapeutic efficacy. Therefore, there is an urgent need for more effective and safer treatments. Hovenia dulcis is an herbal medicine promoting alcohol removal clearance, lipid-lowering, anti-inflammatory, and hepatoprotective properties. Hovenia dulcis has a variety of chemical components such as dihydromyricetin, quercetin and beta-sitosterol, which can affect ALD through multiple pathways, including ethanol metabolism, immune response, hepatic fibrosis, oxidative stress, autophagy, lipid metabolism, and intestinal barrier, suggesting its promising role in the treatment of ALD. Thus, this work aims to comprehensively review the chemical composition of Hovenia dulcis and the molecular mechanisms involved in the process of ALD treatment.

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Section: Pathophysiology Of Aldmentioning

confidence: 99%

Section: Mechanism Of Action Of Hovenia Dulcis In the Treatment Of Al...mentioning

confidence: 99%

Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease

He,

Liu,

Wang

et al. 2024

Front. Pharmacol.

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“…Reducing the level of oxidative stress and minimizing liver damage can prevent and treat alcoholic liver injury (Su et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Zhang,

Liu,

et al. 2024

Journal of Food Science

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Polysaccharides from natural sources can regulate the composition of intestinal flora through the “gut‐liver axis” pathway, potentially ameliorating alcoholic liver injury. Aspalathus linearis, also known as rooibos, is one such natural product that has shown promise in this regard. This study looked at the structural properties of A. linearis polysaccharide (ALP) and how well it would work to treat acute alcoholic liver impairment. This study looks at the composition of monosaccharides, functional groups, and molecular weight (Mw) of a newly discovered water‐soluble polysaccharide, named ALP. The polysaccharide is composed of pyranose rings, amide groups, and sulfate groups linked by β‐glycosidic linkage. It has a relative Mw of 4.30 × 103 kDa and is composed of glucose, rhamnose, and some other monosaccharides. The study found that treating mice with the model of acute alcoholic liver disease with ALP could alleviate pathological symptoms, inhibit the release of inflammatory cytokines, and suppress indicators of oxidative stress. Experiments have shown that different doses of ALP can activate the P4502E1/Keap1‐Nrf2‐HO‐1 signaling pathway. The regulation of inflammatory factors and downstream antioxidant enzymes occurs as a result. Based on these data, it is likely that ALP protects the liver via the “gut‐liver axis” pathway by reducing oxidative stress‐related damage, inflammation, and alcohol‐related alterations to the gut microbiome. The results indicate that ALP mitigates injury caused by oxidative stress, inflammatory responses, and changes in the gut microbiota induced by alcohol through the “gut‐liver axis” pathway, which provides protection to the liver. This provides preliminary evidence for the development of related drugs.Practical ApplicationResearchers extracted a polysaccharide from fresh leaves of Auricularia auricula. The polysaccharide was purified and determined to have a predominantly homogeneous molecular weight. An acute alcoholic liver damage mouse model was established, and it was concluded that the polysaccharide could ameliorate liver injury in mice through the “gut‐liver axis” pathway. This novel polysaccharide can be used as an additive to develop functional foods with beneficial effects, which can positively impact the daily maintenance of consumers.

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Assessing the ability of polysaccharides extracted from date palm fruit to salvage Wistar rats from cisplatin-linked hepatic damage

Adewale,

Oyelola,

Oladele

et al. 2024

Pharmacological Research - Modern Chinese Medicine

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Protective Effects and Mechanism of Polysaccharides from Edible Medicinal Plants in Alcoholic Liver Injury: A Review

Cited by 3 publications

References 69 publications

Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease

Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Assessing the ability of polysaccharides extracted from date palm fruit to salvage Wistar rats from cisplatin-linked hepatic damage

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