Assessing the ability of polysaccharides extracted from date palm fruit to salvage Wistar rats from cisplatin-linked hepatic damage

Adewale, Omowumi Oyeronke; Oyelola, Roseline Faderera; Oladele, Johnson Olaleye; Agbaje, Wasiu Bolade

doi:10.1016/j.prmcm.2024.100400

Cited by 3 publications

(1 citation statement)

References 80 publications

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“…The results showed that Snct-P, Gnkgo-P, and ML-P had significant DPPH-scavenging activities when compared with other crude polysaccharides, while Snct-P had the highest activity among the three; this is evident by its lowest IC 50 among the three. These three crude polysaccharides showed dose-dependent activities, which suggests that they possess radical-reducing capacities [55] with increasing doses and that they can act as hydrogen ion donors and free radical scavengers [56].…”

Section: Discussionmentioning

confidence: 95%

Screening of Antioxidative and Antiproliferative Activities of Crude Polysaccharides Extracted from Six Different Plants

Adewale,

Wińska,

Krawczyk

et al. 2024

Applied Sciences

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Plant polysaccharides have gained interest in medical research for their ability to suppress various diseases, including cancer. However, information on some plant polysaccharides is yet to be uncovered. In this study, we screened crude polysaccharides extracted from six different plants for their antioxidative and antiproliferative activities. Crude polysaccharides were isolated from different parts of some plants using the established extraction protocol. The crude polysaccharides were evaluated for their chemical composition (protein, total sugar, and phenolics), free radical-scavenging activities, and antiproliferative activities against breast cancer MCF-7 cells as well as non-cancerous cells, i.e., human fibroblast MRC-5 cells and Cercopithecus aethiops kidney Vero cells, via an MTT assay and CM20 Incubation Monitoring System (Olympus) for MCF-7. The investigated crude polysaccharides showed significant variations in their chemical constituents and antioxidative properties. Only Moringa seed crude polysaccharide extracts showed significant antiproliferative activities at various concentrations, with an IC50 value of 0.061 mg/mL, which was about 2.6 folds higher on MRC-5 and Vero cell lines. The antiproliferative activities toward cancer cell lines and lack of significant toxicity in the case of normal cells indicate that this extract may be promising as a valuable source for novel cancer therapy.

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Section: Discussionmentioning

confidence: 95%

Screening of Antioxidative and Antiproliferative Activities of Crude Polysaccharides Extracted from Six Different Plants

Adewale,

Wińska,

Krawczyk

et al. 2024

Applied Sciences

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Water-soluble phenolics from Phoenix dactylifera fruits as potential reno-protective agent against cisplatin-induced toxicity: pre- and post-treatment strategies

Adewale,

Oyelola,

Adetuyi

et al. 2024

Drug and Chemical Toxicology

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Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Pedrosa,

Fabi

2024

Plants

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Plants are a core part of cultural identity, as part of a diet, decorations, ceremonies, or as medicinal agents. Empirical knowledge regarding plants and their healing potential has existed worldwide for centuries. With the advance of science and technology, not only is the refinement of such sources or isolation of specific compounds possible, but these compounds can also be characterized based on their natural occurrence. Besides their importance for plant metabolism and structure, polysaccharides have been demonstrated to have substantial positive human health impacts on inflammation, metabolism, oxidative stress, and others. As an inherent part of plant cell walls, many polysaccharides from medicinal herbs, such as fructans, glucans, and pectins, have been extracted and analyzed for their structure and function. However, a review summarizing a significant portion of these studies was still unavailable. This review helps to fill the knowledge gap between polysaccharide bioactivity, their structure, and their plant matrix sources, focusing on historical medicinal usage.

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Assessing the ability of polysaccharides extracted from date palm fruit to salvage Wistar rats from cisplatin-linked hepatic damage

Cited by 3 publications

References 80 publications

Screening of Antioxidative and Antiproliferative Activities of Crude Polysaccharides Extracted from Six Different Plants

Screening of Antioxidative and Antiproliferative Activities of Crude Polysaccharides Extracted from Six Different Plants

Water-soluble phenolics from Phoenix dactylifera fruits as potential reno-protective agent against cisplatin-induced toxicity: pre- and post-treatment strategies

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

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