Protective effect of α‐tocopherol on oxidative stress in experimental pulmonary fibrosis in rats

Değer, Yeter; Yur, Fatmagül; Ertekin, Ali; Mert, Nihat; Dede, Semiha; Mert, Handan

doi:10.1002/cbf.1362

Cited by 29 publications

(14 citation statements)

References 36 publications

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“…In order to investigate whether catalase activity and mRNA are also decreased during the development of lung fibrosis, C57BL/6J mice were subjected to intratracheal administration of bleomycin. The levels of catalase activity in whole lung homogenates were significantly lower at 7, 14, and 21 days after intratracheal bleomycin administration compared with untreated controls (p < 0.01) (Figure 3A), which is in line with the findings of previous studies [32,33]. Whole lung catalase mRNA expression was significantly decreased at 7 and 14 days after intratracheal bleomycin administration compared with controls (p < 0.01, respectively) (Figure 3B).…”

Section: Resultssupporting

confidence: 92%

The Role of Catalase in Pulmonary Fibrosis

et al. 2010

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BackgroundCatalase is preferentially expressed in bronchiolar and alveolar epithelial cells, and acts as an endogenous antioxidant enzyme in normal lungs. We thus postulated epithelial damage would be associated with a functional deficiency of catalase during the development of lung fibrosis.MethodsThe present study evaluates the expression of catalase mRNA and protein in human interstitial pneumonias and in mouse bleomycin-induced lung injury. We examined the degree of bleomycin-induced inflammation and fibrosis in the mice with lowered catalase activity.ResultsIn humans, catalase was decreased at the levels of activity, protein content and mRNA expression in fibrotic lungs (n = 12) compared to control lungs (n = 10). Immunohistochemistry revealed a decrease in catalase in bronchiolar epithelium and abnormal re-epithelialization in fibrotic areas. In C57BL/6J mice, catalase activity was suppressed along with downregulation of catalase mRNA in whole lung homogenates after bleomycin administration. In acatalasemic mice, neutrophilic inflammation was prolonged until 14 days, and there was a higher degree of lung fibrosis in association with a higher level of transforming growth factor-β expression and total collagen content following bleomycin treatment compared to wild-type mice.ConclusionsTaken together, these findings demonstrate diminished catalase expression and activity in human pulmonary fibrosis and suggest the protective role of catalase against bleomycin-induced inflammation and subsequent fibrosis.

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Section: Resultssupporting

confidence: 92%

The Role of Catalase in Pulmonary Fibrosis

et al. 2010

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“…Thus, a number of studies have been carried out to determine the protective effects of vitamin E in different biological models of injury (Chen & Tappel 1995). Değer et al (2007) proved that the pulmonary formation of fibriosis prevents vitamin E supplementation. Kato et al (1990) noted that the concentration of vitamin E in the lung tissue increased significantly after intratrecheal administration of BLM.…”

Section: Blm: Bleomycinmentioning

confidence: 99%

The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats

Çelikezen¹,

Oto²,

Özdemir³

et al. 2015

Bitlis Eren University Journal of Science and Technology

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The purpose of this study is to investigate the antioxidant effects boric acid and CoQ10 has on pulmonary fibrosis in bleomycin induced rats. 32 wistar albino male rats were used in this study. The rats were categorised in four groups; a control group (only given normal saline), a bleomycin (BLM) group, a BLM + boric acid group, and a BLM + boric acid + CoQ10. The study period was adjusted to 30 days. Retinol, vitamin E, vitamin D, catalase, carbonic anhydrase, glucose, total protein, albumin, globulin, and total bilirubin levels were measured at the end of the study. There was a significant increase in the vitamin E levels of all groups (p<0.05). There was a statistically significant increase in the glucose level of all groups (P<0.001). There were significant decreases in albumin and total protein levels of all groups. While the significance level of the decrease in the albumin level was p<0.001, the significance level of the decrease in the total protein level was p<0.05. There was no significant difference in other biochemical parameters.

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“…The catalytic antioxidant porphyrin MnTBAP attenuates bleomycin-induced lung fibrosis in mice (148). The administration of vitamin E has also been shown to have protective effects, and its deficiency potentiates bleomycin-induced lung fibrosis in animals (57,58,142,188). Thiolcontaining antioxidants have been extensively studied in the bleomycin model of lung fibrosis.…”

Section: Fibrogenic Drugs Antioxidants and Oxidative Stressmentioning

confidence: 99%

Antioxidants as Potential Therapeutics for Lung Fibrosis

Day

2008

Antioxidants & Redox Signaling

124

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Interstitial lung disease encompasses a large group of chronic lung disorders associated with excessive tissue remodeling, scarring, and fibrosis. The evidence of a redox imbalance in lung fibrosis is substantial, and the rationale for testing antioxidants as potential new therapeutics for lung fibrosis is appealing. Current animal models of lung fibrosis have clear involvement of ROS in their pathogenesis. New classes of antioxidant agents divided into catalytic antioxidant mimetics and antioxidant scavengers are being developed. The catalytic antioxidant class is based on endogenous antioxidant enzymes and includes the manganese-containing macrocyclics, porphyrins, salens, and the non-metal-containing nitroxides. The antioxidant scavenging class is based on endogenous antioxidant molecules and includes the vitamin E analogues, thiols, lazaroids, and polyphenolic agents. Numerous studies have shown oxidative stress to be associated with many interstitial lung diseases and that these agents are effective in attenuating fibroproliferative responses in the lung of animals and humans.

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Protective effect of α‐tocopherol on oxidative stress in experimental pulmonary fibrosis in rats

Cited by 29 publications

References 36 publications

The Role of Catalase in Pulmonary Fibrosis

The Role of Catalase in Pulmonary Fibrosis

The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats

Antioxidants as Potential Therapeutics for Lung Fibrosis

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