Protective effect of vitamin E against alloxan-induced mouse hyperglycemia

Takemoto, Kazunori; Doi, Wakana; Masuoka, Noriyoshi

doi:10.1016/j.bbadis.2015.12.022

Cited by 17 publications

(11 citation statements)

References 21 publications

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“…In terms of glucose regulation, α-tocopherol showed promising hypoglycemic effects in animal studies, by increasing insulin-secreting cells in the pancreas and insulin production, while reducing oxidative products and apoptosis in the pancreas [111,112]. α-tocopherol was less potent as compared to T3 mixture in reducing the plasma glucose or insulin levels in diabetic rats [19,52].…”

Section: Difference In the Metabolic Effect Between T3 And Alpha-tmentioning

confidence: 99%

The Role of Tocotrienol in Protecting Against Metabolic Diseases

Pang¹,

Chin

2019

Molecules

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Obesity is a major risk factor for diabetes, and these two metabolic conditions cause significant healthcare burden worldwide. Chronic inflammation and increased oxidative stress due to exposure of cells to excess nutrients in obesity may trigger insulin resistance and pancreatic β-cell dysfunction. Tocotrienol, as a functional food component with anti-inflammatory, antioxidant, and cell signaling-mediating effects, may be a potential agent to complement the current management of obesity and diabetes. The review aimed to summarize the current evidence on the anti-obesity and antidiabetic effects of tocotrienol. Previous studies showed that tocotrienol could suppress adipogenesis and, subsequently, reduce body weight and fat mass in animals. This was achieved by regulating pathways of lipid metabolism and fatty acid biosynthesis. It could also reduce the expression of transcription factors regulating adipogenesis and increase apoptosis of adipocytes. In diabetic models, tocotrienol was shown to improve glucose homeostasis. Activation of peroxisome proliferator-activated receptors was suggested to be responsible for these effects. Tocotrienol also prevented multiple systemic complications due to obesity and diabetes in animal models through suppression of inflammation and oxidative stress. Several clinical trials have been conducted to validate the antidiabetic of tocotrienol, but the results were heterogeneous. There is no evidence showing the anti-obesity effects of tocotrienol in humans. Considering the limitations of the current studies, tocotrienol has the potential to be a functional food component to aid in the management of patients with obesity and diabetes.

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Section: Difference In the Metabolic Effect Between T3 And Alpha-tmentioning

confidence: 99%

The Role of Tocotrienol in Protecting Against Metabolic Diseases

Pang¹,

Chin

2019

Molecules

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“…Several researchers reported that dietary intake of A. awamori improved an intestinal environment and induced increase of α-tocopherol (vitamin E) level in their blood and muscles to affect the lipid and protein metabolism (El-Deep et al, 2014;Saleh et al, 2013Saleh et al, , 2014. As the intake of vitamin E improved mouse hyperglycemia caused by alloxan and vitamin E improved insulin release from pancreas damaged by alloxan (Kamimura et al, 2013;Takemoto, Doi, & Masuoka, 2016), we deduced that A. awamori is an effective probiotic and increases vitamin E to ameliorate hyperglycemia induced by oxidative stress. Therefore, A. awamori may be likely to be applicable as a supplement if untoward side effects are not observed.…”

Section: Discussionmentioning

confidence: 85%

Effect of Asperagillus awamori on Alloxan-induced Mouse Hyperglycemia

Masuda¹,

Okachi²,

Hirao³

et al. 2017

JFR

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Problem statement: Though alloxan-induced mouse hyperglycemia was ameliorated by feeding of 5 % Asperagillus awamori (A. awamori)-fermented burdock root diet (fermented burdock diet), it is unclear whether the anti-hyperglycemia activity is due to A. awamori or antioxidant activity induced by the fermentation.Methods: A 0.05 % A. awamori diet was prepared. Acatalasemic mice, having a quite low catalase activity in blood, were divided three groups, and each group fed control, A. awamori and the fermented burdock diets for 14 weeks, separately. Then, alloxan monohydrate (200 mg/ kg of body weight) was intraperitoneally administrated to each mouse. Glucose, insulin, C-peptide contents in blood and glucose tolerance tests (GTTs) were examined.Results: Incidence of alloxan-induced hyperglycemia in acatalasemic mice maintained with the A. awamori diet or the fermented burdock diet was low (20 or 25%) compared to that (75%) maintained with the control diet. Feeding the A. awamori diet ameliorated insulin, C-peptide in blood and GTT like as mice fed the fermented burdock diet. It indicated that A. awamori in these diets plays an important role for the prevention of alloxan-induced hyperglycemia.Conclusions: It is suggested that A. awamori has the anti-hyperglycemia activity.

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“…Vitamin E, because of its antioxidant activity, is believed to be promising therapeutic alternative T1DM and T2DM. Supplementation with vitamin E has been reported to ameliorate mouse hyperglycemia through improving secretion of insulin from alloxantreated islet [44]. In vivo, rats with streptozotocin-induced DM were shown to present significant decrease in glucose level and improved antioxidant enzymes activities, including glutathione reductase, glutathione peroxidase, and catalase, after vitamin E supplementation.…”

Section: Vitamin E For T1dm and T2dm Treatmentmentioning

confidence: 99%

Medicinal Plants, Bioactive Compounds, and Dietary Therapies for Treating Type 1 and Type 2 Diabetes Mellitus

Awuchi¹

2022

Natural Drugs From Plants

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Medicinal plants, bioactive compounds, and dietary measures have been found to be effective in the treatment of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). About 463 million people have diabetes worldwide; estimates project 700 million people by 2045. While T1DM is caused by the loss of beta cells of pancreatic islets that produce insulin, resulting in the deficiency of insulin, T2DM, which constitutes over 90 to 95% of all DM cases, is caused by insulin resistance, and could relatively combine reduction in the secretion of insulin. Aloe vera, Terminalia chebula, Perilla frutescens, Curcuma longa, Zingiber zerumbet, Nigella sativa, Gongronema latifolium, Pachira aquatic, Caesalpinioideae, Azadirachta indica, Artemisia dracunculus, Artemisia herbaalba, Vachellia nilotica, Abelmoschus moschatus, Cinnamomum verum, Salvia officinalis, Tinospora cordifoli, Pterocarpus, Ocimum tenuiflorum, Mangifera indica, Syzygium cumini, Coccinia grandis, Caesalpinia bonduc, Gymnema sylvestre, Carthamus tinctorius, Allium sativum, and Trigonella foenum-graecum are among the medicinal plants shown to be effective in controlling and treating T1DM and T2DM. Bioactive compounds such as lycopene, vitamin E, vitamin D, genistein, quercetin, resveratrol, epigallocatechin-3-gallate, hesperidin, naringin, anthocyanin, etc. are useful in treating T1DM and T2DM.

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Protective effect of vitamin E against alloxan-induced mouse hyperglycemia

Abstract: It is suggested that the difference in the mice fed vitamin E supplemented diet is due to an increase of insulin secretion and that vitamin E supplementation may have a role in helping to slow the stages of diabetes mellitus.

Cited by 17 publications

References 21 publications

The Role of Tocotrienol in Protecting Against Metabolic Diseases

The Role of Tocotrienol in Protecting Against Metabolic Diseases

Effect of Asperagillus awamori on Alloxan-induced Mouse Hyperglycemia

Medicinal Plants, Bioactive Compounds, and Dietary Therapies for Treating Type 1 and Type 2 Diabetes Mellitus

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