Protective effect of vitamin B5 (dexpanthenol) on cardiovascular damage induced by streptozocin in rats

Abstract

Objectives: This study investigated whether Dexpanthenol (DEX) improves diabetic cardiovascular function and cardiac performance by regulating total oxidant and antioxidant status. Methods: Diabetes was induced by a single intraperitoneal injection of Streptozocin (50 mg/kg in 1 ml of saline) and treatment groups received DEX (300 mg/kg/day) for 6 weeks. Endothelium (in)dependent relaxation responses were assessed in thoracic aortic rings and coronary vasculature together with alpha receptor and voltage dependant contractile responses of aorta. Myocardial contractility has been recorded by an intra ventricular latex balloon. Total oxidant and antioxidant status were measured from the serum samples. Results: Induction of diabetes resulted in an apparent body weight loss, high blood glucose, endothelial dysfunction and increased serum oxidant status. DEX supplementation restored the endothelial dysfunction, antioxidant status and body weight whereas decreasing blood glucose level. Conclusion: Along with the standard therapy of diabetes, DEX can be used as a safe and economical way of adjuvant therapy to diminish the burden of the disease (Tab.

Among the water-soluble vitamins, dietary intakes of vitamins C, B2and folate are associated with the reduced risk of diabetes in Japanese women but not men

“…However, most of the available research on B-group vitamins/T2DM associations has concentrated on vitamins B 6 , folate and vitamin B 12 , and has shown inconsistent findings (10)(11)(12) . Similar large studies to investigate the associations of other B vitamin intakes, such as vitamin B 1 (thiamine), B 2 (riboflavin), B 3 (niacin) and B 5 (pantothenic acid) are scarce (13)(14)(15)(16)(17)(18) . Moreover, the previous observations were either for the vitamin B-group status (11,13,17) or supplemental (8,9,12,(14)(15)(16)18) rather than dietary intakes (7) .…”

“…Similar large studies to investigate the associations of other B vitamin intakes, such as vitamin B 1 (thiamine), B 2 (riboflavin), B 3 (niacin) and B 5 (pantothenic acid) are scarce (13)(14)(15)(16)(17)(18) . Moreover, the previous observations were either for the vitamin B-group status (11,13,17) or supplemental (8,9,12,(14)(15)(16)18) rather than dietary intakes (7) . Therefore, in the present analysis, we aimed to investigate the association between dietary consumptions of the whole set of water-soluble vitamins (B 1 , B 2 , B 3 , B 5 , B 6 , B 9 , B 12 and C) and the risk of 5-year cumulative incidence of T2DM among a large cohort of Japanese men and women, hypothesising that intakes of at least some of these water-soluble vitamins could associate inversely with the risk of T2DM.…”

Moroccan Bee Bread Improves Biochemical and Histological Changes of the Brain, Liver, and Kidneys Induced by Titanium Dioxide Nanoparticles

“…The coadministration of BB extract for 30 days (Group 4) was able to reduce hyperglycemia, which is in agreement with the finding of Capcarova et al [ 23 ]. Hypoglycemic activity of BB extract might be due to the interaction between its individual molecules, especially flavonoids vitamins C and B [ 54 ]. Indeed, Al-Ishaq et al reported that flavonoid derivatives reduce hyperglycemia by modulating glucose transport in addition to their powerful antioxidant capacities [ 55 ].…”

Curative role of pantothenic acid in brain damage of gamma irradiated rats

“…The modulator role of pantothenic acid in the radiationinduced oxidative stress might be associated to its effectiveness in the scavenging of free radicals [66,67] and the improvement of the antioxidant status [68,69]. In this respect, pantothenic acid, by regulating the Krebs cycle activity, would contribute in the synthesis of GSH by increasing the production of NADPH [70].…”