Protective effect of vanillic acid in hydrogen peroxide-induced oxidative stress in D.Mel-2 cell line

Taqvi, Shagufta; Bhat, Eijaz Ahmed; Sajjad, Nasreena; Sabir, Jamal S. M.; Qureshi, Aleem; Rather, Irfan A.; Rehman, Suriya

doi:10.1016/j.sjbs.2020.12.023

Cited by 22 publications

(21 citation statements)

References 25 publications

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“…In the present work, a significant increase of both SOD and CAT activities was observed in the H 2 O 2 -exposed C. viridis brain cells pretreated with SCG at 230 µg/mL and 460 µg/mL (Figure 3). Similarly, as found in this study, Taqvi et al [44] demonstrated that vanillic acid, a phenolic acid, exerts antioxidant effects against H 2 O 2 -induced oxidative stress in D.Mel-2 cells. Cells exposed to H 2 O 2 significantly increased lipid peroxidation and reduced activity of SOD, CAT and GPx.…”

Section: Discussionsupporting

confidence: 88%

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Polyphenolic Extracts from Spent Coffee Grounds Prevent H2O2-Induced Oxidative Stress in Centropomus viridis Brain Cells

et al. 2021

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Oxidative stress in aquatic organisms might suppress the immune system and propagate infectious diseases. This study aimed to investigate the protective effect of polyphenolic extracts from spent coffee grounds (SCG) against oxidative stress, induced by H2O2, in C. viridis brain cells, through an in vitro model. Hydrophilic extracts from SCG are rich in quinic, ferulic and caffeic acids and showed antioxidant capacity in DPPH, ORAC and FRAP assays. Furthermore, pretreatment of C. viridis brain cells with the polyphenolic extracts from SCG (230 and 460 µg/mL) for 24 h prior to 100 µM H2O2 exposure (1 h) significantly increased antioxidant enzymes activity (superoxide dismutase and catalase) and reduced lipid peroxidation (measured by MDA levels). These results suggest that polyphenols found in SCG extracts exert an antioxidative protective effect against oxidative stress in C. viridis brain cells by stimulating the activity of SOD and CAT.

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Section: Discussionsupporting

confidence: 88%

“…Cells exposed to H 2 O 2 significantly increased lipid peroxidation and reduced activity of SOD, CAT and GPx. D.Mel-2 cells treated with vanillic acid (0.25%) reduced lipid peroxidation and increased the activity of the antioxidant enzymes [44].…”

Section: Discussionmentioning

confidence: 95%

Polyphenolic Extracts from Spent Coffee Grounds Prevent H2O2-Induced Oxidative Stress in Centropomus viridis Brain Cells

et al. 2021

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“…We believe that the protective effect of the A. thwaitesianum fruit extract may be related to its chemical components, polyphenols, and flavonoids. We identified the presence of ferulic acid, caffeic acid, vanillic acid, protocatechuic acid, and cyanidin, which have been previously described as antioxidant compounds with anti-inflammatory and photo-protective properties [ 35 , 36 , 37 , 38 , 39 ]. The DPPH assay revealed that the fruit extract could act as electron and proton donors that stabilize DPPH free radicals.…”

Section: Discussionmentioning

confidence: 99%

Photo-Protective and Anti-Inflammatory Effects of Antidesma thwaitesianum Müll. Arg. Fruit Extract against UVB-Induced Keratinocyte Cell Damage

et al. 2022

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The main cause of most skin cancers is damage from UVB from sunlight, which penetrate the skin surface and induce inflammation. For this reason, this study aims to identify natural products with photo-protection properties and their mode of action by using the UVB-irradiated HaCaT keratinocyte model. Antidesma thwaitesianum fruit extracts at 25, 50, and 100 µg/mL recovered cell viability following UVB exposure in a dose-dependent manner. Cell survival was associated with the reduction in intracellular ROS and NO. In addition, we showed that the pre-treatment with the fruit extract lowered the phosphorylation level of two MAPK-signaling pathways: p38 MAPKs and JNKs. The resulting lower MAPK activation decreased their downstream pro-inflammatory cascade through COX-2 expression and subsequently reduced the PGE2 proinflammatory mediator level. The photoprotective effects of the fruit extract were correlated with the presence of polyphenolic compounds, including cyanidin, ferulic acid, caffeic acid, vanillic acid, and protocatechuic acid, which have been previously described as antioxidant and anti-inflammation. Together, we demonstrated that the pre-treatment with the fruit extract had photo-protection by inhibiting oxidative stress and subsequently lowered stress-induced MAPK responses. Therefore, this fresh fruit is worthy of investigation to be utilized as a skincare ingredient for preventing UVB-induced skin damage.

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“…In this study, 15 phenolic compounds were characterized, including vanillic acid, 4-coumaric acid, ferulic acid, astragalin, afzelin, and curcumin. In the previous studies, vanillic acid, a bioactive phenolic compound, was proven to antioxidant and inhibit oxidative stress [ 31 – 33 ], which have anti-inflammatory and neuroprotective effects [ 34 , 35 ]. In addition, the plant phenolic acid 4-coumaric acid protected against oxidative DNA damage in rat colonic mucosa and ultraviolet B-induced oxidative DNA damage in rabbit corneal-derived cells [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus

Wang

et al. 2021

BioMed Research International

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Stahlianthus involucratus (S. involucratus) has anti-inflammatory, antinociceptive, and antipyretic activities; however, there are no literature reports on its antioxidant capacity. This study presents a comparative assessment of the polyphenols contents, flavonoids contents, and antioxidant activity of the aqueous and methanol extracts of S. involucratus (ASI and MSI). Moreover, the expression of oxidative stress-related genes in H2O2-induced H9c2 cells pretreated with the MSI was measured by RT-qPCR, and furthermore, MSI were characterized by UHPLC-Q-Orbitrap-MS/MS. The results indicated that the MSI had higher antioxidant contents and antioxidant capacity, and MSI could inhibit H2O2-induced oxidative stress in H9c2 cells by activating the Nrf2/HO-1 pathway. UHPLC-Q-Orbitrap-MS/MS characterized 15 phenolic compounds from the MSI. In conclusion, S. involucratus has the potential antioxidant capacity.

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Protective effect of vanillic acid in hydrogen peroxide-induced oxidative stress in D.Mel-2 cell line

Cited by 22 publications

References 25 publications

Polyphenolic Extracts from Spent Coffee Grounds Prevent H2O2-Induced Oxidative Stress in Centropomus viridis Brain Cells

Polyphenolic Extracts from Spent Coffee Grounds Prevent H2O2-Induced Oxidative Stress in Centropomus viridis Brain Cells

Photo-Protective and Anti-Inflammatory Effects of Antidesma thwaitesianum Müll. Arg. Fruit Extract against UVB-Induced Keratinocyte Cell Damage

The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus

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