Protective effect of Vaccinium arctostaphylos L. fruit extract on gentamicin-induced nephrotoxicity in rats

Bazm, Mohsen Akbari; Khazaei, Mozafar; Ghanbari, Elham; Naseri, Leila

doi:10.1007/s00580-018-2743-0

Cited by 14 publications

(10 citation statements)

References 30 publications

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“…Treatment groups received V. arctostaphylos L . extract and OM for 50 days through gavage (Bazm, Khazaei, Ghanbari, & Naseri, and Akbari Bazm, Khazaei, Khazaei, & Naseri, ).…”

Section: Methodsmentioning

confidence: 99%

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The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

et al. 2020

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Anabolic androgenic steroids (AAS) such as oxymetholone (OM) used for athletic enhancement, but increased free radicals damage and changes in hormonal levels, lead to serious and irreversible organ damage. Vaccinium arctostaphylos(V. arctostaphylos( has been demonstrated to have antioxidant and antiinflammatory effects. The aim of present study was to investigate V. arctostaphylos effect on OM‐induced oxidative injury in mouse testis and sperm parameters. In this experimental study, 30 BALB/c mice were divided into five groups, including healthy, positive control(5 mg/kg OM) and three treatment groups (100, 200 and 400 mg/kg of V. arctostaphylos extract + 5 mg/kg OM). At the end of the study, serum luteinizing hormone (LH), follicle‐stimulating hormone (FSH) and testosterone levels were measured. Testis stereological and sperm parameters were calculated. Antioxidant status was measured using nitric oxide (NO) and FRAP assay, and malondialdehyde (MDA) levels. Furthermore, the expression of p53, caspase‐3, Bax and Bcl‐2 was measured. V. arctostaphylos decreased the serum level of testosterone, increased the LH and FSH, and improved the stereological and sperm parameters and down‐regulated the p53, caspase‐3 and Bax and up‐regulated Bcl‐2 genes. Furthermore, this dose decreased serum levels of NO and increased testis FRAP and MDA levels in treated groups compared with OM group. V. arctostaphylos extract has protective effects against testicular toxicity caused by OM.

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“…Treatment groups received V. arctostaphylos L . extract and OM for 50 days through gavage (Bazm, Khazaei, Ghanbari, & Naseri, and Akbari Bazm, Khazaei, Khazaei, & Naseri, ).…”

Section: Methodsmentioning

confidence: 99%

“…Group 2: Positive control group, oxymetholone (OM): received 5 ml/kg OM dissolved in 0.5 ml DW (ratio of 1:1). Naseri, 2018 and.…”

Section: Experimental Design and Treatmentsmentioning

confidence: 99%

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

et al. 2020

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“…1442125) and dried at room temperature. Finally, after evaporation of alcohol, 30 g of the extract was stored at 4°C (Ahmeda, Zangeneh, & Zangeneh, 2020; Bazm, Khazaei, Ghanbari, & Naseri, 2018; Bazm, Naseri, & Khazaei, 2018).…”

Section: Methodsmentioning

confidence: 99%

Doxorubicin and Trifolium pratense L. (Red clover) extract synergistically inhibits brain and lung metastases in 4T1 tumor‐bearing BALB/c mice

Akbaribazm

Khazaei

et al. 2020

Food Science & Nutrition

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Breast cancer (BC) is the most common malignancy in women with 18% prevalence and 1 million new cases each year. This cancer showed the highest mortality in the United States and claimed a mortality rate of 89.2 per 100,000 in the world in 2000 (Aurit, Devesa, Soliman, & Schairer, 2019). BC tumors present a heterogeneous phenotype regarding the expressions of different cellular receptors (estrogen receptors [ER], progesterone receptor [PR], and epidermal growth factor receptor 2 [HER2]) in tumor cells. Studies

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“…To condense the solution, a vacuum distillation unit (Heidolph Collegiate, LABOROTA 4000) at 50°C was used. The 35 g extract was stored at 4°C (Bazm, Khazaei, Ghanbari, & Naseri, ).…”

Section: Methodsmentioning

confidence: 99%

“…The images were processed using Adobe Photoshop CC (Adobe System); then, the stereological parameters of volume (seminiferous tubules, parenchyma and interstitial tissues), length (seminiferous tubules), lumen diameter and germinal epithelium height were calculated. The treatment groups were then compared with the positive control group (OM), (Figure a–c); (Baharan & Goodarzi, ; Bazm et al,).…”

Section: Methodsmentioning

confidence: 99%

Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone‐induced oxidative injury in mouse testis and sperm parameters

Bazm

Khazaei

et al. 2019

Andrologia

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Testicular tissue and sex hormones are sensitive to the anabolic steroids (oxymetholone/OM) due to increased free radical damage and hormonal changes. The Nasturtium officinale L. have various antioxidant compounds. The aim of the present study was to investigate N. officinale effect on OM-induced oxidative injury in mouse testis and sperm parameters. Thirty BALB/c mice were divided into five groups, including control, OM (5 ml/kg) and three N. officinale doses (25, 50 and 100 mg/ kg) + OM. At the end of the study (40 days), serum luteinising hormone (LH), folliclestimulating hormone (FSH), testosterone, nitric oxide (NO) levels, ferric reducing ability of power (FRAP) and testis stereological factors were measured. The sperm parameters were evaluated. Liquid chromatography-electrospray ionisation-tandem mass spectrometry (LC-ESI/MS) analysis was yielded a fingerprint of N. officinale phenolic constituents. 100 mg/kg of N. officinale extract significantly reduced the serum level of testosterone and a significant increase in LH and FSH in comparison with the control group. This dose also significantly improved the stereological factors and sperm parameters. 50 and 100 mg/kg of N. officinale extract significantly increased the testis tissue FRAP levels, and 100 doses reduced the serum levels of NO.Fourteen compounds and 34 peaks were identified in the extract with LC-ESI/MS. Nasturtium officinale extract has protective effects against testicular toxicity caused

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Protective effect of Vaccinium arctostaphylos L. fruit extract on gentamicin-induced nephrotoxicity in rats

Cited by 14 publications

References 30 publications

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

Doxorubicin and Trifolium pratense L. (Red clover) extract synergistically inhibits brain and lung metastases in 4T1 tumor‐bearing BALB/c mice

Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone‐induced oxidative injury in mouse testis and sperm parameters

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