Protective effect of the extracts from Cnidium officinale against oxidative damage induced by hydrogen peroxide via antioxidant effect

Jeong, Jin Boo; Park, Jae Ho; Lee, Hee Kyeong; Ju, So Yeong; Hong, Se Chul; Lee, Jeong Rak; Chung, Gyu Young; Lim, Jae Hwan; Jeong, Hyung Jin

doi:10.1016/j.fct.2008.11.039

Cited by 58 publications

(25 citation statements)

References 25 publications

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“…Natural phenolic compounds display a potential role as chemo-preventive agents. This is considered to be mainly due to their antioxidant, radical scavenging properties and chelating activities [31]. Such antioxidant-based pharmaceutical drugs have been used during the last three decades for the prevention and treatment of complex diseases like atherosclerosis, stroke, diabetes, Alzheimer's disease, and also in cancer therapy [32].…”

Section: Introductionmentioning

confidence: 99%

Supplemental UV‐B induced changes in leaf morphology, physiology and secondary metabolites of an Indian aromatic plantCymbopogon citratus(D.C.) Staph under natural field conditions

Kumari

Agrawal

2010

International Journal of Environmental Studies

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Cymbopogon citratus (D.C.) Staph, an aromatic perennial herb, is known to have great potential as a medicinal plant. In our study, we investigated in realistic field conditions the effect of supplemental ultraviolet-B (sUV-B) at two levels (+1.8 and +3.6 kJ m −2 d −1 above ambient) on various growth, physiological and biochemical characteristics of C. citratus. A higher dose of sUV-B produced a 17.6% reduction in biomass while at a lower dose the characteristics remained unaffected. The sUV-B imparted its negative effects to chlorophyll contents while an increment was noticed for carotenoids and phenolic compounds. No significant change in the rate of photosynthesis was noticed. The SEM observation revealed dense waxy deposition on the adaxial surface of exposed leaves at a lower dose of sUV-B to increase epidermal transmittance. This study clearly indicated the beneficial effect of sUV-B on volatile oils production in C. citratus plants grown under a low dose of sUV-B.

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Section: Introductionmentioning

confidence: 99%

Supplemental UV‐B induced changes in leaf morphology, physiology and secondary metabolites of an Indian aromatic plantCymbopogon citratus(D.C.) Staph under natural field conditions

Kumari

Agrawal

2010

International Journal of Environmental Studies

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“…The toxic effects are caused by reactive species called "oxygen radicals" [1]. Some of the reactive oxygen species (ROS), including hydrogen peroxide, singlet oxygen, hydroxyl and superoxide radicals, have positive roles in energy production in in vivo systems, phagocytosis, intercellular signal transfer, regulation of cell growth and the synthesis of important biological compounds [2].…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and In vitro antioxidant and antidiabetic activities of Eucalyptus Camaldulensis Dehnh. essential oil

Başak

Candan

2010

JICS

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The present study was designed to determine the composition of the essential oil of Eucalyptus camaldulensis Dehnh. leaves and to examine its in vitro antioxidant and antidiabetic activities. The chemical composition of the essential oil from Eucalyptus camaldulensis Dehnh. leaves was analyzed by GC/GC-MS, twenty-nine compounds representing 99.10% of the total oil were identified. The major components of the oil were p-cymene (68.43%), 1,8-cineole (13.92%), 1-(S)-Į-pinene (3.45%) and R-(+)-limonene (2.84%). The antioxidant features of the essential oil were evaluated using inhibition of 2,2-diphenyl-1-picrylhydrazyl, hydroxyl, and superoxide radicals, inhibition of hydrogen peroxide and lipid peroxidation assays. We also studied Į-amylase and Į-glucosidase inhibition in vitro to assess the antidiabetic properties of the essential oil. Both Į-amylase and Į-glucosidase were inhibited by a non-competitive mechanism.

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“…22 It has been reported that C. officinale extract has the protective effects against ultraviolet B (UVB)-induced DNA damage, and H 2 O 2 -induced DNA and cell damage in the human skin fibroblast cell. 23,24 Though it was reported that Z-ligustilide, its bioactive metabolites of C. officinale, has the antiinflammatory effect by suppressing the NF-κB pathway, its extract has not been reported it has the protective effect on skin disorder.…”

Section: Discussionmentioning

confidence: 99%

The Amelioration Effect of the Ethanolic Extract of Cnidium officinale in Mice with Imiquimod-induced Psoriasis-like Skin Lesion

et al. 2018

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− Psoriasis is an auto-immune skin disease, which is characterized by the excessive generation of plaques on the skin with typically a long-lasting red, itchy and scaly symptoms. Imiquimod, which has been used for the treatment of external genital warts, actinic keratosis, and superficial basal cell carcinoma, induced of psoriasis-like skin disorders with skin erythema and thickness in mice. In the present study, we tried to find the bioactive herbal extract against imiquimod-induced psoriasis-like skin disorder in mice. During the searching of the herbal extract with anti-psoriatic effect, the ethanolic extract of Cnidium officinale ameliorated imiquimodinduced psoriasis-like skin disorder in mice. The morphological evaluation, H&E staining and Psoriasis Area and Severity Index (PASI) score showed that ear and back thickness, and erythema induced by imiquimod were significantly reversed after the treatment of the cream of the ethanolic extract of C. officinale. The overexpressed myeloperoxidase (MPO) and keratin 6A levels were decreased by the treatment of C. officinale cream. Also, IFN-γ, c-fos and IκB-α mRNA levels, which are related to the progression of psoriasis, were reduced by C. officinale cream. Thus, the ethanolic extract of C. officinale ameliorated psoriasis-like skin disorder induced by imiquimod and might be the therapeutic agent for psoriasis.

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Protective effect of the extracts from Cnidium officinale against oxidative damage induced by hydrogen peroxide via antioxidant effect

Cited by 58 publications

References 25 publications

Supplemental UV‐B induced changes in leaf morphology, physiology and secondary metabolites of an Indian aromatic plantCymbopogon citratus(D.C.) Staph under natural field conditions

Supplemental UV‐B induced changes in leaf morphology, physiology and secondary metabolites of an Indian aromatic plantCymbopogon citratus(D.C.) Staph under natural field conditions

Chemical composition and In vitro antioxidant and antidiabetic activities of Eucalyptus Camaldulensis Dehnh. essential oil

The Amelioration Effect of the Ethanolic Extract of Cnidium officinale in Mice with Imiquimod-induced Psoriasis-like Skin Lesion

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