Protective effect of the association of curcumin with piperine on prostatic lesions: New perspectives on BPA-induced carcinogenesis

Facina, Camila Helena; Campos, Silvana G. P.; Ruiz, Thalles Fernando Rocha; Góes, Rejane Maira; Vilamaior, Patrícia Simone Leite; Taboga, Sebastião Roberto

doi:10.1016/j.fct.2021.112700

Cited by 13 publications

(8 citation statements)

References 54 publications

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“…As a result, it can reduce the risk of causing cancer due to DNA adducts (Sehgal et al, 2013). Moreover, the anticarcinogenic effect of this combination has been reported in prostatic lobes (Facina et al, 2021). Table 4 summarizes the in vitro and in vivo studies investigating the anticancer effects of the combination of curcumin and piperine.…”

Section: The Anticancer Efficacy Of Single Polyphenols Plus Their Com...mentioning

confidence: 93%

“…As a result, it can reduce the risk of causing cancer due to DNA adducts (Sehgal et al, 2013). Moreover, the anticarcinogenic effect of this combination has been reported in prostatic lobes (Facina et al, 2021). Table 4 summarizes Anticancer efficacy of this combinatory treatment includes cell cycle arrest at the G2/M checkpoint, the over-expressed gene of caspase3, and the increase in apoptotic cell percentage (Bolat et al, 2020).…”

Section: Piperine and Curcumin-piperine Combinationmentioning

confidence: 99%

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Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets

Ghobadi

Asoodeh

2023

Phytotherapy Research

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Natural plant phytochemicals are effective against different types of diseases, including cancer. Curcumin, a powerful herbal polyphenol, exerts inhibitory effects on cancer cell proliferation, angiogenesis, invasion, and metastasis through interaction with different molecular targets. However, the clinical use of curcumin is limited due to poor solubility in water and metabolism in the liver and intestine. The synergistic effects of curcumin with some phytochemicals such as resveratrol, quercetin, epigallocatechin-3-gallate, and piperine can improve its clinical efficacy in cancer treatment. The present review specifically focuses on anticancer mechanisms related to the co-administration of curcumin with other phytochemicals, including resveratrol, quercetin, epigallocatechin-3-gallate, and piperine. According to the molecular evidence, the phytochemical combinations exert synergistic effects on suppressing cell proliferation, reducing cellular invasion, and inducing apoptosis and cell cycle arrest. This review also emphasizes the significance of the co-delivery vehicles-based nanoparticles of such bioactive phytochemicals that could improve their bioavailability and reduce their systemic dose. Further highquality studies are needed to firmly establish the clinical efficacy of the phytochemical combinations.

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Section: The Anticancer Efficacy Of Single Polyphenols Plus Their Com...mentioning

confidence: 93%

“…As a result, it can reduce the risk of causing cancer due to DNA adducts (Sehgal et al, 2013). Moreover, the anticarcinogenic effect of this combination has been reported in prostatic lobes (Facina et al, 2021). Table 4 summarizes Anticancer efficacy of this combinatory treatment includes cell cycle arrest at the G2/M checkpoint, the over-expressed gene of caspase3, and the increase in apoptotic cell percentage (Bolat et al, 2020).…”

Section: Piperine and Curcumin-piperine Combinationmentioning

confidence: 99%

Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets

Ghobadi

Asoodeh

2023

Phytotherapy Research

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“…Nevertheless, results of another study were not convincing enough. [167] On the other hand, some in vivo studies suggest that piperine can have a strong potent protective effect on curcumin against carcinogens [168][169][170][171]. It cannot also be neglected that piperine suppresses the expression of IL-1β in gastric cancer cells induced by H. pylori and inflammation in pyloric mucosa of Mongolian gerbils after infection [172].…”

Section: Curcumin Formulations: Data From Clinical Trialsmentioning

confidence: 99%

Therapeutic potential and limitations of curcumin as antimetastatic agent

Dytrych¹,

Kejík²,

Hajduch³

et al. 2023

Biomedicine & Pharmacotherapy

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“…1 Curcumin is one of the most interesting compounds being investigated, with many different possible uses. [32][33][34][35][36][37] Curcumin has not demonstrated yet good clinical results due to weak absorption and metabolism. However, compounds derived from curcumin are promising.…”

Section: Direct Chemopreventive Agentsmentioning

confidence: 99%

Natural Products as Cancer Chemo Preventive Agents: Where We Stand

Boretti¹

2022

Natural Product Communications

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This work briefly reviews cancer chemoprevention. This is a very challenging field, as products with a high level of toxicity such as chemotherapeutic agents may be proposed and accepted only under life-threatening conditions. Cancer chemoprevention is otherwise limited to completely safe substances, preferably having neither toxic nor side effects, administered in relatively low amounts. Phases of clinical trials, therapeutic end-points, and biomarkers of chemoprevention are difficult to be defined. The clinical trials needed to prove the efficacy of chemopreventive agents must be very long and extremely widespread to achieve significance, with many variables difficult to control, and therefore subjected to many confounding factors. This makes them almost impossible. It is, therefore, no surprise, if the progress of chemoprevention has been so far very limited. There are only a few examples of direct use of chemopreventive agents, under investigation, but with anything but established protocols, in addition to indirect uses such as general supplementation with antioxidant, anti-inflammatory, and immune-supportive agents. Cancer chemoprevention remains a potentially very rewarding approach, certainly worth further study, but extremely difficult to pursue, in need of different methodological approaches to producing valuable chemopreventive compounds of clear dosages and benefits.

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Protective effect of the association of curcumin with piperine on prostatic lesions: New perspectives on BPA-induced carcinogenesis

Cited by 13 publications

References 54 publications

Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets

Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets

Therapeutic potential and limitations of curcumin as antimetastatic agent

Natural Products as Cancer Chemo Preventive Agents: Where We Stand

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