Protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion in adult male rat

Ameli, Mojtaba; Hashemi, Mohaddeseh Sadat; Moghimian, Maryam; Shokoohi, Majid

doi:10.1111/and.13068

Cited by 46 publications

(71 citation statements)

References 24 publications

(41 reference statements)

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“…Also, a lot of drugs in this group, like amlodipine, nifedipine, verapamil and lidocaine, have antioxidant properties (Arena et al, 2017). Sarica et al (1999) reduce the I/R damage and the sperm parameters assessment in various groups indicated that verapamil cannot remarkably meliorate the sperm characteristics; it is perhaps based on verapamil calcium channel-blocking activity that perhaps blocked the Ca2+/Na+ channels of spermatozoa and could not increase the motility and percentage of normal spermatozoa (Ameli et al, 2018). Also, Juneja et al (1990) and Moger (1983) have revealed that sperm quality diminishes followed by administration of calcium channel blockers like verapamil (Juneja et al, 1990;Moger, 1983).…”

Section: Deepa Et Al In Research On the Impacts Of Heparin On Cell Pmentioning

confidence: 99%

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The effects of verapamil and heparin co‐administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats

et al. 2019

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In this research, the impacts of combined administration of verapamil and heparin on testicular torsion damage were examined. In this experimental study, 30 sexually mature male Wistar albino rats were divided into five equal groups haphazardly (n = 6): Group 1 was the sham group. In group 2, a 2‐hr testicular torsion was induced, and thereafter, detorsion was done. Rats in group 3 and group 4 experienced an identical surgical procedure like group 2, but verapamil and heparin were administered in 0.3 mg/kg and 800 IU/kg doses respectively, and in group 5, a combination of verapamil and heparin were administered. Intraperitoneal drug injection in all treatment groups was done 30 min before testicular detorsion. Testicular torsion significantly changed sperm parameters, oxidative stress biomarkers and Cosentino's histological score compared to the sham group (p < .05). All treatment groups reduced testicular damage by decreasing oxidative stress and improving sperm parameters, but heparin and co‐administration of verapamil and heparin were significantly better than verapamil injection alone. However, heparin injected group was more effective than other treatment groups (p < .05). Overall, an anticoagulant like heparin is more effective than a calcium channel blocker such as verapamil, and it is more likely to reduce testicular torsion injuries.

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Section: Deepa Et Al In Research On the Impacts Of Heparin On Cell Pmentioning

confidence: 99%

“…In a research about verapamil's protective effects on testicular tissue conducted byAmeli et al (2018), it was found that verapamil can *p < .05 compared with the sham group. In a research about verapamil's protective effects on testicular tissue conducted byAmeli et al (2018), it was found that verapamil can *p < .05 compared with the sham group.…”

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The effects of verapamil and heparin co‐administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats

et al. 2019

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“…Testicular torsion is a urological emergency, which can ultimately cause losing of gonads (Ameli et al, 2018). Probability of this complication occurrence is high in pubertal period, but it can occur at any age (Gökçe et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have proved that I/R injury is relevant to high levels of MDA (Ameli et al, 2018;Avlan et al, 2005;Gökçe et al, 2010;Wilhelm Filho et al, 2004). Several studies have proved that I/R injury is relevant to high levels of MDA (Ameli et al, 2018;Avlan et al, 2005;Gökçe et al, 2010;Wilhelm Filho et al, 2004).…”

Section: Stevia Rebaudiana Is a Shrub With Numerous Medical Featuresmentioning

confidence: 99%

“…It is prevalent at any age with the estimation of one in 4,000 males, but the medical literature reveals that this clinical condition has mostly been observed in the population of adolescents ages especially 25 years old (Moghimian, Abtahi-Evari, Shokoohi, Amiri, & Soltani, 2017; Moghimian, Soltani, Abtahi, Adabi, & Jajarmy, 2016). Testicular torsion/detorsion (T/D) causes testicular ischaemia-reperfusion (I/R) injury that can lead to the alterations in biochemical and histopathological values (Ameli, Hashemi, Moghimian, & Shokoohi, 2018;Wilhelm Filho, Torres, Bordin, Crezcynski-Pasa, & Boveris, 2004); however, torsion degree and its duration highly affect the complications of this damage (Ameli et al, 2018;Moghimian et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Protective effects ofStevia rebaudianaaqueous extract on experimental unilateral testicular ischaemia/reperfusion injury in rats

2019

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This project aimed to examine Stevia rebaudiana aqueous extract protective effects on testicular ischaemia/reperfusion injury of rats. Forty rats were randomly divided into five groups: (1) sham group, (2) torsion/detorsion group, (3 and 4) low and high doses treatment groups received S. rebaudiana extract intraperitoneally 30 min before detorsion by 500 and 1,000 mg/kg respectively, and (5) healthy group received the extract by 1,000 mg/kg. In this study, left testes were rotated 2 hr, reperfusion period took long 5 hr, and then orchiectomy was performed. Histopathological and biochemical evaluations of testicular tissue samples were performed.Histopathologically, sham and healthy groups exhibited normal seminiferous tubules.Germinal cell necrosis, interstitial oedema, haemorrhage and congestion were seen in torsion/detorsion group. Testicular tissues of both treatment groups revealed lower histopathological alterations. Significant higher malondialdehyde level was observed in torsion/detorsion group than sham and healthy groups (p < .05). Compared with torsion/detorsion group, S. rebaudiana extract significantly reduced malondialdehyde level in treatment groups (p < .05). Torsion/detorsion group had significantly lower glutathione peroxidase and superoxide dismutase activities than sham and healthy groups, and these parameters showed significant increase in treatment groups compared with torsion/detorsion group (p < .05). The results revealed S. rebaudiana has this potential to protect the testes from ischaemia/reperfusion injury. K E Y W O R D Sischaemia/reperfusion injury, Stevia rebaudiana, testis

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The antioxidant effects of hydroalcoholic extract of Ashrasi date palm on sperm parameters and DNA fragmentation in diabetic rats

Hosseinipour

Asgari

Kermani

et al. 2022

Anim Models and Exp Med

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Diabetes is a metabolic disorder in which the blood glucose level is increased because of a lack of insulin production or a reduction in insulin sensitivity and function. 1 Diabetes causes injury to different organs and leads to their dysfunctions and failures. 2 One of the complications of diabetes can be disruption of reproductive system of men. 3 The metabolism of glucose is a key factor during

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Protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion in adult male rat

Abstract: Tadalafil and verapamil can be protected the testis tissue damage and replaced the testicular function by suppressing oxidative stress after testicular torsion.

Cited by 46 publications

References 24 publications

The effects of verapamil and heparin co‐administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats

The effects of verapamil and heparin co‐administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats

Protective effects ofStevia rebaudianaaqueous extract on experimental unilateral testicular ischaemia/reperfusion injury in rats

The antioxidant effects of hydroalcoholic extract of Ashrasi date palm on sperm parameters and DNA fragmentation in diabetic rats

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