Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats

Posadas, S; Caz, Víctor; Largo, Carlota; Gándara, B. De la; Matallanas, B.; Reglero, Guillermo; Miguel, Enrique de

doi:10.1016/j.exger.2009.02.015

Cited by 80 publications

(64 citation statements)

References 60 publications

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“…In fact, these changes in antioxidant enzyme activity are markedly variable depending on sex, tissues and even on the animal model or analytic techniques employed (Posadas et al 2009). Previous studies from our group have found reduced CAT in leukocytes from both old and prematurely aging mice (Alvarado et al 2006;Arranz et al 2010a).…”

Section: Discussionmentioning

confidence: 98%

The aged-related increase in xanthine oxidase expression and activity in several tissues from mice is not shown in long-lived animals

et al. 2011

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Xanthine oxidase (XO) is an important source of oxidant production and plays an essential role in several oxidative stress-related diseases. Aging is associated with a progressive deregulation of homeostasis as a result of a chronic oxidative stress situation. In the present work the age-related changes in XO expression and activity, as well as the activities of superoxide dismutase and catalase have been investigated in liver, kidney and thymus from four different age groups of mice, including long-lived animals. Furthermore, we have evaluated the contribution of the XO to the oxidative stress-associated with aging, in comparison to another enzymatic key source of oxidant generation, the NADPH oxidase, in peritoneal leukocytes from old mice. In all the tissues analyzed, the old mice showed higher activity and expression of XO, and decreased or unchanged superoxide dismutase and catalase activities as compared with adult mice. Moreover, the inhibition of reactive oxygen species with allopurinol or apocynin in peritoneal leukocytes from old mice, suggest that both XO and NADPH oxidase contribute to the generation of superoxide anion, whereas the XO may have a special relevance in the production of hydrogen peroxyde. Finally, long-lived animals showed a well-preserved redox state, in terms of antioxidant defenses and oxidant compounds in tissues and immune cells, which may be related to the ability of these subjects to reach a very advanced age in healthy condition. These results confirm that XO plays an important role in the age-related oxidative stress in tissues and immune cells.

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Section: Discussionmentioning

confidence: 98%

The aged-related increase in xanthine oxidase expression and activity in several tissues from mice is not shown in long-lived animals

et al. 2011

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“…The first three were expected, common in wheat, they are responsible for a series of biological effects, with antioxidant and anti-inflammatory action (Santos et al, 2011). The carnosic acid however, is a common component of rosemary (Rosmarinus officinalis), which has also had antioxidant proprieties described (Posadas et al, 2009). Wheat extracts have a pro-inflammatory action (Souza et al, 2006), increasing fibroblast migration into the injured site.…”

Section: Discussionmentioning

confidence: 99%

Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model

Tillmann

Felix

Mueller

et al. 2014

Arq. Bras. Med. Vet. Zootec.

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While Triticum sp. has been shown to act in wound healing, stimulating collagen synthesis by fibroblasts, the use of this plant extract has yet to be assessed in vivo, in commercially viable presentations. This study used rabbits and assessed, on days seven, 14, and 21, the presence or absence of granulation tissue and epithelialization, histopathological structures, and scar quality through the breaking and tension strength. Treatments, performed for 21 days, were aqueous extract of T. aestivum at a concentration of 2mg/mL (group I) and 10mg/mL (group II) and a nonionic cream (control group). We demonstrate that the formation of granulation tissue was not significantly different between treatments. In the analysis of epithelial tissue, wounds in group II differed from other treatments by day 7. On days 14 and 21 there was no significant clinical difference between groups. In the histopathological evaluation, scar quality and rupture strength did not differ between the groups in the studied period. In the tension strength evaluation, group I differed from the others, presenting a higher tension strength overall. The studied treatments did not differ regarding healing evolution of the skin wounds, but T. aestivum extract, at 2mg/mL, presents better results in the tension strength evaluation.

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“…Rosmarinus officinalis (R. officinalis) has been used in the prevention of flap necrosis (5); it is known to exert antimicrobial (6-10), antioxidant (11)(12)(13)(14)(15)(16)(17)(18), anti-inflammatory (19,20), antifungal (6,9,10), antidiabetic (15), anticarcinogenic (13,19), antiplatelet (21), antimetastatic (13,19), antiproliferative (16) and antimutagenic (22) effects.…”

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confidence: 99%

Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps

et al. 2016

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Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats

Cited by 80 publications

References 60 publications

The aged-related increase in xanthine oxidase expression and activity in several tissues from mice is not shown in long-lived animals

The aged-related increase in xanthine oxidase expression and activity in several tissues from mice is not shown in long-lived animals

Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model

Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps

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