Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Aβ25–35-induced cognitive deficits in mice

Ruan, Changgeng; Si, Jianmin; Zhang, Li; Chen, Di-Hua; Du, Guanhua; Sun, Lan

doi:10.1016/j.neulet.2009.10.029

Cited by 32 publications

(27 citation statements)

References 23 publications

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“…I.c.v. Injection of in mice resulted in learning and memory deficits that were accompanied by a decrease of choline-acetyltransferase and an increase of cholinesterase activity, suggesting that accumulation of Aβ disrupted cholinergic activity and caused the cognitive impairments of AD (Maurice et al, 1996;Ruan et al, 2009;Tohda et al, 2004). The deposition of Aβ in the pathogenesis of AD is invariably associated with oxidative stress and inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

Jung¹,

Song²,

Seong³

2012

Korean Journal of Medicinal Crop Science

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Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

Jung¹,

Song²,

Seong³

2012

Korean Journal of Medicinal Crop Science

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“…1 filter paper, and the filtrate was concentrated using a rotary vacuum evaporator to yield an ethanol extract (220 g) that was stored at room temperature until required. Induction of memory impairment and administration of I. latifolia extract Memory impairment in the mice was induced by icv injection of 15 nmol of the aggregated form of Ab (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), as previously described. 21 I. latifolia extract (25,50, and 100 mg/kg) suspended in distilled water and donepezil (2 mg/kg) were orally administered 30 min before Ab (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) treatment and were further given on a daily basis for 7 days.…”

Section: Plant Materials and Extract Preparationmentioning

confidence: 99%

“…21 At 30 min after the administration of I. latifolia and donepezil on day 7 following icv injection of Ab (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), the mice were trained for a step-through passive avoidance task. A retention trial was performed 24 h after the training trial.…”

Section: Reagentsmentioning

confidence: 99%

“…After the test, locomotor activity and motor coordination were measured using a photobeam monitoring system (AM1051; Benwick Electronics, Benwick, United Kingdom) and rota rod apparatus (775 Rota rod, IITC Life Science Inc., Woodland Hills, CA, USA), respectively. These measurements were taken to eliminate any possible effects of Ab (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) on general motor function. Each mouse was placed in the center of the activity cage, and the total number of mobile counts was registered for 5 min.…”

Section: Reagentsmentioning

confidence: 99%

“…14 We isolated antioxidant compounds, caffeoylquinic acid derivatives (CQAs), which are potentially responsible for the neuroprotection conferred by I. latifolia, 15 as shown by other groups. [16][17][18] In the present study, we determined whether I. latifolia exerts a protective effect against memory deficits induced by a single intracerebroventricular (icv) injection of Ab (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) in mice, an AD-type amnesia model, 19,20 and investigated the underlying mechanisms. In addition, the protective effects of I. latifolia on Ab (25-35)-induced neuronal damage were studied in cultured rat cortical neurons.…”

Section: Introduction Amentioning

confidence: 99%

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Ilex latifoliaPrevents AmyloidβProtein (25–35)-Induced Memory Impairment by Inhibiting Apoptosis and Tau Phosphorylation in Mice

Kim

Lee

Jang

et al. 2015

Journal of Medicinal Food

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Ilex latifolia Thunb. (Aquifoliaceae), a Chinese bitter tea called ''kudingcha,'' has been widely consumed as a health beverage and found to possess antioxidant, antidiabetic, antihypertensive, anti-inflammatory, and anti-ischemic activities. The aim of the present study was to investigate the neuroprotective effects of an ethanol extract of I. latifolia against amyloid b protein (Ab)-induced memory impairment in mice and neurotoxicity in cultured rat cortical neurons. Memory impairment in mice was induced by intracerebroventricular injection of 15 nmol Ab (25-35) and measured by the passive avoidance test and Morris water maze test. Chronic administration of I. latifolia (25-100 mg/kg, p.o.) significantly prevented Ab (25-35)-induced memory loss. I. latifolia also prevented the decrease of glutathione concentrations, increased lipid peroxidation, expression of phosphorylated tau (p-tau), and changes in apoptosis-associated proteins in the memory-impaired mouse brain. Exposure of cultured cortical neurons to 10 lM Ab (25-35) for 36 h induced neuronal apoptotic death. The neuronal cell death, elevation of intracellular Ca 2+ concentration, generation of reactive oxygen species, and expression of proapoptotic proteins caused by in the cultured neurons were inhibited by treatment with I. latifolia (1-50 lg/mL). These results suggest that I. latifolia may have a possible therapeutic role in managing cognitive impairment associated with Alzheimer's disease. The underlying mechanism might involve the antiapoptotic effects mediated by antioxidant activity and inhibition of p-tau formation.

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Natural products and their derivatives as multifunctional ligands against Alzheimer's disease

Patil

Thakur

Sharma

et al. 2019

Drug Development Research

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Alzheimer's disease (AD), a complex neurodegenerative disorder causing multiple cellular changes including impaired cholinergic system, beta‐amyloid (βA) aggregation, tau hyperphosphorylation, metal dyshomeostasis, neuroinflammation, and many other pathways are involved in the pathogenesis of the disease. However, the exact cause of the disease is not known. Natural products such as flavonoids, alkaloids, resveratrol, and curcumin have multifunctional properties, and have drawn the attention of the researchers because these molecules are capable of interacting concurrently with the multiple targets of AD. Therefore, natural products and their derivatives with proven efficacy could be used in the management of the neurodegenerative disorders. This review focuses on the natural product based multitarget directed ligands like tacrine‐coumarin, tacrine‐huperzine A, harmine‐isoxazoline, berberine‐thiophenyl, galantamine‐indole, pyridoxine‐resveratrol, donepezil‐curcumin and their mode of action.

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Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Aβ25–35-induced cognitive deficits in mice

Cited by 32 publications

References 23 publications

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

Ilex latifoliaPrevents AmyloidβProtein (25–35)-Induced Memory Impairment by Inhibiting Apoptosis and Tau Phosphorylation in Mice

Natural products and their derivatives as multifunctional ligands against Alzheimer's disease

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