Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis

Rousta, Ali Mohammad; Mirahmadi, Seyed-Mohamad-Sadegh; Shahmohammadi, Alireza; Nourabadi, Davood; Khajevand-Khazaei, Mohammad-Reza; Baluchnejadmojarad, Tourandokht; Roghani, Mehrdad

doi:10.1080/08923973.2018.1523926

Cited by 34 publications

(19 citation statements)

References 53 publications

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“…interferon γ (IFNγ)-inducible protein 10 (IP-10/CXCL10)) in human primary monocytes and THP-1 cells ( Hsieh et al, 2014 ). The anti-inflammatory effects of sesamin have also been observed in different in vivo models ( Cui et al, 2010 , Lin et al, 2014 , Ahmad et al, 2016 , Zhang et al, 2016 , Li et al, 2016 , Fan et al, 2017 , Rousta et al, 2018 , Zhao et al, 2019 , Bai et al, 2019 , Lin et al, 2019 , Sayhan et al, 2019 Ali et al, 2020 ). Consistently, sesamin has been shown to suppress a series of inflammatory markers associated with type-II diabetes and rheumatoid arthritis in humans ( Mohammad Shahi et al, 2017 , Helli et al, 2019 ).…”

Section: Anti-inflammatory Effects Of Sesaminmentioning

confidence: 90%

Health benefits of sesamin on cardiovascular disease and its associated risk factors

Dalibalta

Majdalawieh

Manjikian

2020

Saudi Pharmaceutical Journal

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Sesamin, a major lignin isolated from sesame ( Sesamum indicum ) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehensive review summarizes the evidence on the effects of sesamin on CVD and its risk factors, principally due to its antioxidant properties. Specifically, this review highlights the mechanisms underlying the anti-hypertensive, anti-atherogenic, anti-thrombotic, anti-diabetic, and anti-obesity, lipolytic effects of sesamin both in vivo and in vitro , and identifies the signaling pathways targeted by sesamin and its metabolites. The data indicates that RAS/MAPK, PI3K/AKT, ERK1/2, p38, p53, IL-6, TNFα, and NF-κB signaling networks are all involved in moderating the various effects of sesamin on CVD and its risk factors. In conclusion, the experimental evidence suggesting that sesamin can reduce CVD risk is convincing. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat CVD and its multitude of risk factors.

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Section: Anti-inflammatory Effects Of Sesaminmentioning

confidence: 90%

Health benefits of sesamin on cardiovascular disease and its associated risk factors

Dalibalta

Majdalawieh

Manjikian

2020

Saudi Pharmaceutical Journal

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“…It has recently been reported that sesamin (at a single dose of 25-100 mg/kg) given orally one hour before intraperitoneal injection of lipopolysaccharide (LPS) was effective in protecting mice from LPS-induced acute kidney injury (AKI) by reducing renal oxidative stress, inflammation, and apoptosis (Rousta et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…For example, sesamin has been reported to protect against cardiac remodeling in rodents induced by transverse aortic constriction via the Sirt3/ROS pathway (Fan et al 2017), several dietary restriction-related signaling pathways, including processes requiring SIRT1, TOR, and AMPK in Caenorhabditis elegans, and the inhibition of the TLR4 expression and NF-κB activation in LPS-induced acute lung injury in mice (Qiang et al 2016). NF-κB activation, toll-like receptor 4 (TLR4), cyclooxygenase-2 (COX2), tumor necrosis factor α (TNF-α), interleukin-6, DNA fragmentation and Nrf2 have been suggested to be the mechanisms involved in LPS-induced AKI in mice (Rousta et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage

et al. 2020

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Nephrotoxicity of cisplatin (CP) involves renal oxidative stress and inflammation, and sesamin (a major liganin in many plants) has strong antioxidant and antiinflammatory actions. Therefore, we investigated here the possible mitigative action of sesamin on CP nephrotoxicity in rats. Sesamin was given orally (5 mg/kg/day, 10 days), and on the 7th day, some of the treated rats were injected intraperitoneally with either saline or CP (5 mg/kg). On the 11th day, rats were sacrificed, and blood and urine samples and kidneys were collected for biochemical estimation of several traditional and novel indices of renal damage in plasma and urine, several oxidative and nitrosative indices in kidneys, and assessment of histopathological renal damage. CP significantly and adversely altered all the physiological, biochemical and histopathological indices of renal function measured. Kidneys of CP‐treated rats had a moderate degree of necrosis. This was markedly lessened when CP was given simultaneously with sesamin. Sesamin treatment did not significantly alter the renal CP concentration. The results suggested that sesamin had ameliorated CP nephrotoxicity in rats by reversing the CP-induced oxidative stress and inflammation. Pending further pharmacological and toxicological studies sesamin may be considered a potentially useful nephroprotective agent.

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“…Septic AKI is considered a major public health concern in today’s world, however, there is no effective treatment for it. Accumulation studies have demonstrated that the pathological process of septic AKI was highly associated with excessive inflammatory response and renal cell apoptosis [22,23]. Here, we investigated the functions of miR-191-5p in septic rat models and found that the injection of miR-191-5p mimic could observably inhibit renal injury scores.…”

Section: Discussionmentioning

confidence: 88%

“…In our study, the injection of miR-191-5p mimic had a potently suppressive effect on the levels of serum TNF-α, IL-1β and IL-6 in septic rat models, which may indicate that miR-191-5p might be a possible therapeutic target for the treatment of septic AKI. Cell apoptosis is also a contributing factor that is strongly involved in the development of AKI, and many agents with the abilities of anti-inflammation and anti-apoptosis are promising for prevention of AKI [23,29]. Consistent with our results, the up-regulated Bcl-2 and down-regulated Bax and C caspase-3 in rat kidneys of M group may suggest that a portion of the protective effect of miR-191-5p on rat kidneys might be attributed to its ability to regulate apoptotic proteins.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-191-5p diminished sepsis-induced acute kidney injury through targeting oxidative stress responsive 1 in rat models

2019

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There is no effective treatment for septic acute kidney injury (AKI), which is considered a major public health concern in today’s world. Here, we studied the functions of miR-191-5p in septic AKI. MiR-191-5p mimic or mimic control was injected into rats from caudal vein before cecal ligation and puncture (CLP) surgery. Part of kidney tissues was stained by Hematoxylin and Eosin (H&E) for histological examination. The levels of serum cytokines were evaluated using enzyme-linked immunosorbent assay (ELISA). For cell transfection, renal cells were isolated from the kidneys of CLP rat model injected with mimic control and miR-191-5p mimic. With TargetScan prediction, serine/threonine-protein kinase OSR1 was identified as a target of miR-191-5p. Oxidative stress responsive 1 (OXSR1) overexpression vector was transfected into renal cells. Cell viability and apoptosis rate were determined by Cell Counting Kit-8 (CCK-8) and flow cytometry, respectively. We additionally measured the phosphorylation levels of p38 and p65. We found that the injection of miR-191-5p mimic could observably inhibit renal injury scores, and inhibit inflammatory cytokine productions and apoptotic protein levels in septic rats. After being transfected with OXSR1, the apoptosis rates and expressions of B-cell lymphoma-2 (Bcl-2), down-regulated Bax and Cleaved caspase-3 (C caspase-3) indicated overexpressed OXSR1 contributed to cell apoptosis. The up-regulated protein levels of p-p38 and p-p65 may suggest the involvement of p38 MAPK/NF-κB signaling pathway in the functions of OXSR1. Our results showed that the protective effects of miR-191-5p on kidney tissues of septic rats may rely on the repression of OXSR1.

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Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis

Cited by 34 publications

References 53 publications

Health benefits of sesamin on cardiovascular disease and its associated risk factors

Health benefits of sesamin on cardiovascular disease and its associated risk factors

Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage

MicroRNA-191-5p diminished sepsis-induced acute kidney injury through targeting oxidative stress responsive 1 in rat models

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