Protective Effect of Selenoarginine against Oxidative Stress in<scp>D</scp>-Galactose-Induced Aging Mice

Liu, Anjun; Ma, Yongmin; Zhu, Zhiwei

doi:10.1271/bbb.80558

Cited by 36 publications

(25 citation statements)

References 21 publications

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“…Therefore, this animal model has been widely used for brain aging and antiaging pharmacology studies. MDA, a metabolic product of lipid peroxidation, is often used a marker of oxidative injury and an indicator of aging (Liu et al 2009). GSH-px also is an important indicator in aging assessment (Liu et al 2009).…”

Section: Discussionmentioning

confidence: 99%

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FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging

Fang

Wang

Liu

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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The aim of this study was to investigate the protective effects of N-[2-(4-hydroxy-phenyl)-ethyl]-2-(2,5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide (FLZ), a synthetic squamosamide cyclic derivative, on senescent mice induced by D: -galactose/NaNO(2) (120/90 mg/kg, i.p.) once daily for 60 days. FLZ (75 and 150 mg/kg) was orally administered once daily for 30 days after D: -galactose/NaNO(2) treatment for 30 days. The cognitive function of mice was evaluated with step-down task. The brain biomarkers including monoamine oxidase B (MAO-B), glutathione peroxidase (GSH-px), and malondialdehyde (MDA) were determined according to the manufacturer's instructions. The expression of acetylcholinesterase (ACh-E) and choline acetyltransferase (ChAT) protein in the CA1 region of hippocampus were counted by immunohistochemical staining. The results showed that the cognitive function, GSH-px activity in the brain, and the expression of ACh-E and ChAT in the CA1 region of hippocampus were significantly decreased, while MAO-B activity and MDA level in the brain were increased in senescent mice compared with the control mice. FLZ treatment prolonged the step-down latency and decreased the number of step-down errors in the senescent mice. In addition, FLZ treatment increased the GSH-px activity and the expression of ACh-E and ChAT in the hippocampus and decreased the MDA level and MAO-B activity compared with the senescent mice without drug administration. These findings suggested that FLZ improves the performance in the step-down task and the pathological alternations in senescent mice.

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Section: Discussionmentioning

confidence: 99%

“…MDA, a metabolic product of lipid peroxidation, is often used a marker of oxidative injury and an indicator of aging (Liu et al 2009). GSH-px also is an important indicator in aging assessment (Liu et al 2009). It is a kind of anti-oxidant enzymes in vivo, which can eliminate the free radicals to prevent cells from oxidative injury.…”

Section: Discussionmentioning

confidence: 99%

FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging

Fang

Wang

Liu

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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“…(3) D-Galactose induced mimetic ageing model group (n = 8, 20-week-old). After acclimatization to laboratory conditions, one of these 20-week-old rat groups received daily intraperitoneal injection of D-galactose at a dosage of 60 mg/kg/day for 6 weeks, whereas naturally ageing and control groups were injected with saline (0.9%) only (Liu et al 2009). At the end of the treatment, the rats were sacrificed following an overnight fast, and the kidneys were immediately collected for homogenization.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats

et al. 2011

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Ageing of kidneys is a clinical health issue of the society. Age-related renal insufficiency has important implications due to impaired redox homeostasis. We examined protein, DNA and lipid oxidation biomarkers as well as protein-bound sialic acid (SA) in the kidney tissues of D-galactose induced ageing rats, naturally aged rats and their corresponding young control group. Intraperitoneal injection of D-galactose (60 mg/kg/day) for 6 weeks to young male Sprague-Dawley rats (20-week-old) was used to establish mimetic ageing model. In this study, we investigated the levels of protein carbonyl groups (PCO), various thiol fractions such as total thiol groups (T-SH), protein (P-SH) and non-protein thiol groups (NP-SH), lipid oxidation parameters such as lipid hydroperoxides (LHP) and malondialdehyde (MDA), SA and 8-hydroxy-2'deoxyguanosine (8-OHdG) parameters for comparison of naturally aged, induced aged and young rats. In D-galactose induced aged group, PCO, LHP, MDA, and 8-OHdG concentrations were significantly higher than young control group, whereas T-SH, P-SH levels were significantly lower than the young rats. In addition, NP-SH and SA concentrations were similar between the mimetic ageing and young control groups. In naturally ageing rats, PCO and MDA levels were significantly higher, whereas T-SH, P-SH, NP-SH concentrations were low compared to young controls. On the other hand, SA and 8-OHdG levels were not different between the naturally ageing group and the young control group. Our results demonstrated that the rats in the mimetic ageing group, have significant similarities with the naturally aged rats in terms of impaired redox homeostasis and can be used as a reliable animal model for renal ageing.

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“…SOD catalyzes the dismutation of superoxide to oxygen and hydrogen peroxide [12], which is catalyzed next by GPx with GSH as an electron donor [39]. It has been shown that the level of MDA increases, but GPx and SOD activity decreases in kidney with aging [40,41].…”

Section: Discussionmentioning

confidence: 99%

Not Only Melatonin but also Caffeic Acid Phenethyl Ester Protects Kidneys against Aging-related Oxidative Damage in Sprague Dawley Rats

Eşrefoğlu

Iraz

Ateş

et al. 2012

Ultrastructural Pathology

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Microscopic features and antioxidant status of kidneys of young, old, and caffeic acid phenethyl ester (CAPE) and melatonin administered old Sprague Dawley rats were evaluated. Aging-related tubular and glomerular changes were evident. The most prominent tubular alterations were massive vacuole formation, mitochondrial degeneration, and lysosome accumulation. Mean tissue malondialdehyde (MDA) level was increased, mean tissue superoxide dismutase (SOD), catalase (CAT) (p < .001), and glutathione peroxidase (GPx) activities (p < .05), and total glutathione (GSH) level were decreased in old animals. Melatonin significantly reduced tissue MDA levels (p < .005), but increased tissue SOD (p < .001), CAT, and GPx activities (p < .05), and GSH levels (p < .005) in old animals. CAPE also significantly reduced tissue MDA levels (p < .005), but increased tissue SOD (p < .05), CAT (p < .005), GPx activities, and GSH levels (p < .001) in old rats. Mean tissue MDA levels of melatonin and CAPE-administered rats were even lower than those of young rats (p < .05). In conclusion, tubular and glomerular structures and tissue antioxidant enzyme activities were very well preserved in CAPE and melatonin-administered rats.

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Protective Effect of Selenoarginine against Oxidative Stress inD-Galactose-Induced Aging Mice

Cited by 36 publications

References 21 publications

FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging

FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging

Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats

Not Only Melatonin but also Caffeic Acid Phenethyl Ester Protects Kidneys against Aging-related Oxidative Damage in Sprague Dawley Rats

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