Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model

Mansour, Basma S.; Salem, Noha A.; Kader, Ghada Abdel; Abdel-Alrahman, Gamal; Mahmoud, Omayma M.

doi:10.1016/j.lfs.2021.119099

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Azithromycin is a widely used antibiotic in the treatment protocol of COVID-19 for its antiviral and immunomodulatory effects. Previously, rat models showed that azithromycin produces high free radicals, and thus induces excessive oxidative stress, inflammation, and infraction of myocardial tissue [ 25 ]. Thus, azithromycin induces cardiotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Ameliorates Cardiac and Hepatic Toxicity Induced by Azithromycin-Etoricoxib Drug Interaction

Hamza

Alaryani

Omara³

et al. 2022

CIMB

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The complexity of prescribing safe and effective drug therapy is still challenging. Due to the increased number of medications taken by patients, the potential for drug-drug interactions has clinically important consequences. This study focuses on the potential drug-drug interaction between azithromycin and etoricoxib and the possibility of counteracting this adverse reaction by giving ascorbic acid intraperitoneally to male albino rats. Sixty adult male albino rats weighing 150–180 g were used. The rats were allocated into six equal groups. One group was a control, and the others were given azithromycin, etoricoxib, either alone or combination, with one group treated with ascorbic acid and the last group treated with the drug combination and ascorbic acid. Blood samples were collected for measuring AST, ALT, LDH, CK-MB, and troponin alongside antioxidant enzymes and histopathological examination for both liver and heart tissue. The results showed both hepatic and cardiac damage in azithromycin and etoricoxib groups represented by increasing levels of heaptoc enzymes (ALT, AST, LDH, CK-MB, and troponin) with declining antioxidant enzymes and elevation of malondialdehyde and the appearance of hepatic and cardiac toxicities. Upon administration, ascorbic acid ameliorated all the mentioned biochemical parameters. In conclusion, ascorbic acid has great antioxidant capacities and hepatic and cardiac ameliorative effects and can alleviate drug interaction toxicity.

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Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Ameliorates Cardiac and Hepatic Toxicity Induced by Azithromycin-Etoricoxib Drug Interaction

Hamza

Alaryani

Omara³

et al. 2022

CIMB

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“…Aescin treatment protected the myocardium against ISO-induced damage and restored myocardial architecture to near-normal. Histopathological investigations of cardiac tissues from normal and aescin-only treated rats revealed a healthy morphology of the heart muscle without any necrosis, demonstrating that aescin is nontoxic 42 . Aescin 5 and 20 mg/kg b.w also provided excellent morphological protection by reducing muscle fiber loss with moderate necrosis.…”

Section: Fig 7: Histopathological Studies Of the Heart Tissue Of Norm...mentioning

confidence: 86%

Untitled

2023

IJPSR

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The efficacy of aescin on the liver and cardiac markers, lipid profile, and antioxidant status in rats with myocardial infarction (MI) induced by isoproterenol (ISO) was investigated in this study. Three doses of aescin (5, 10, and 20 mg/kg of b.w) were administered to rats for the first 21 days. After the treatment period, ISO (60 mg/kg of b.w) was given subcutaneously to the rats on the 22 nd and 23 rd day. Cardiovascular and hepatic markers (CK, ALT, CK-MB, AST, cTnI, and cTnT) has been analyzed to investigate cardiac and liver damage. The activities of antioxidant enzymes (CAT, GST, SOD, and GPx) were decreased in both cardiac tissue and erythrocytes of ISO rats. The levels of phospholipids (PLs), total cholesterol (TC), free fatty acids (FFA), and triglycerides (TG) were increased significantly in the serum of the rats administrated with ISO. The results of the present study implies that aescin pretreatment reduces oxidative stress and exhibits cardioprotective action by scavenging the free radicals and maintaining the levels of circulatory and cardiac lipids. Hematoxylin and eosin staining method was used to examine the cardiac histological changes in the experimental rats. The results showed that ISO-administered rats pretreated with aescin reduced cardiac tissue damage compared with ISO-alone injected rats. INTRODUCTION:Myocardial infarction (MI) is a severe health concern in developed and developing countries, affecting a large proportion of the global population and significantly impacting mortality numbers 1 . It is a clinical disorder caused by a sustained restriction of cardiac blood flow, and this mechanism can occur even in minor blockages when cholesterol plaque is disrupted 2 . The cardiac markers detection in serum is essential in the early diagnosis of MI.

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“…Azithromycin (AZM) is a second-generation broad-spectrum synthetic macrolide antibiotic that not only acts against gram-positive and gram-negative bacteria, but also has antiviral and anti-inflammatory effects and is also able to modulate immune responses [ 120 ]. AZM exerts antiviral effects by inducing type I interferon immune responses [ 121 ].…”

Section: Other Potential Antiviral Agentsmentioning

confidence: 99%

The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs

Zeng

Wang

et al. 2022

Microorganisms

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Coronaviruses, mainly including severe acute respiratory syndrome virus, severe acute respiratory syndrome coronavirus 2, Middle East respiratory syndrome virus, human coronavirus OC43, chicken infectious bronchitis virus, porcine infectious gastroenteritis virus, porcine epidemic diarrhea virus, and murine hepatitis virus, can cause severe diseases in humans and livestock. The severe acute respiratory syndrome coronavirus 2 is infecting millions of human beings with high morbidity and mortality worldwide, and the multiplicity of swine epidemic diarrhea coronavirus in swine suggests that coronaviruses seriously jeopardize the safety of public health and that therapeutic intervention is urgently needed. Currently, the most effective methods of prevention and control for coronaviruses are vaccine immunization and pharmacotherapy. However, the emergence of mutated viruses reduces the effectiveness of vaccines. In addition, vaccine developments often lag behind, making it difficult to put them into use early in the outbreak. Therefore, it is meaningful to screen safe, cheap, and broad-spectrum antiviral agents for coronaviruses. This review systematically summarizes the mechanisms and state of anti-human and porcine coronavirus drugs, in order to provide theoretical support for the development of anti-coronavirus drugs and other antivirals.

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Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model

Cited by 5 publications

References 41 publications

Ascorbic Acid Ameliorates Cardiac and Hepatic Toxicity Induced by Azithromycin-Etoricoxib Drug Interaction

Ascorbic Acid Ameliorates Cardiac and Hepatic Toxicity Induced by Azithromycin-Etoricoxib Drug Interaction

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The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs

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