The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs

Abstract

Coronaviruses, mainly including severe acute respiratory syndrome virus, severe acute respiratory syndrome coronavirus 2, Middle East respiratory syndrome virus, human coronavirus OC43, chicken infectious bronchitis virus, porcine infectious gastroenteritis virus, porcine epidemic diarrhea virus, and murine hepatitis virus, can cause severe diseases in humans and livestock. The severe acute respiratory syndrome coronavirus 2 is infecting millions of human beings with high morbidity and mortality worldwide, and the multiplicity of swine epidemic diarrhea coronavirus in swine suggests that coronaviruses seriously jeopardize the safety of public health and that therapeutic intervention is urgently needed. Currently, the most effective methods of prevention and control for coronaviruses are vaccine immunization and pharmacotherapy. However, the emergence of mutated viruses reduces the effectiveness of vaccines. In addition, vaccine developments often lag behind, making it difficult to put them into use early in the outbreak. Therefore, it is meaningful to screen safe, cheap, and broad-spectrum antiviral agents for coronaviruses. This review systematically summarizes the mechanisms and state of anti-human and porcine coronavirus drugs, in order to provide theoretical support for the development of anti-coronavirus drugs and other antivirals.

Antiviral activity of chrysin and naringenin against porcine epidemic diarrhea virus infection

“…In recent years, the antiviral effects of natural compounds, especially plant extracts and Chinese herbal medicines, had been gradually revealed. Due to its advantages of rich sources, unique chemical structure, and diverse activities, natural compounds have gradually been a hot topic in the development of new drugs ( 17 ). Flavonoids are a kind of polyphenols mainly derived from plants.…”