Protective Effect of Resveratrol Co-Administration with Cholesterol Diet on Erythrocyte Osmotic Fragility and Malondialdehyde Concentration in Rabbits

Jimoh, A.; Tanko, Y.; Ahmed, Amran; Mohammed, Aliyu; Ayo, Joseph Olusegun

doi:10.9734/bjpr/2015/15856

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Oxidative stress significantly reduce total red blood cells, hemoglobin, total white blood cells including neutrophils, platelets and packed cell volume [4]. Continuous exposure to ROS renders erythrocyte sensitive to redox imbalance which in in turn increase OF due to ROS induced changes in the molecular properties of the erythrocyte [21].…”

Section: Discussionmentioning

confidence: 99%

Osmotic Fragility and Some Hematological Implications of Chronically Administered Carbamazepine is Attenuated by Resveratrol and Vitamin E Combination

Aliyu

Saleh

et al. 2019

BJSTR

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Carbamazepine (CBZ) as a drug used in the treatment of epilepsy and neuropathic pain has been shown to facilitate the effects of free radicals. Resveratrol (RESV), known as 3,5,4′-trihydroxystilbene, is found in grapes and other plant products. It effectively scavenges free radicals and other oxidants. Vitamin E (Vit E) is a lipid soluble antioxidant present in all cellular membranes. The present study assessed the combined effect of vitamin E and resveratrol on hematological markers of carbamazepine-induced oxidative stress. Adult male Wistar rats (n = 25) were randomly allotted to five groups: Group I (control) received distilled water, Group II received CBZ (50 mg/kg), Group III received CBZ(500mg/kg) and Vitamin E (200 mg/kg); Group IV received of CBZ(50 mg/kg), and resveratrol (20 mg/kg); Group V received CBZ (50 mg/kg) and the coadministration of vitamin E (200 mg/kg) and resveratrol (20 mg/kg). Administration was done orally daily for 45 day after which animals were sacrificed and blood samples were used for biochemical analyses. Hematological parameters such as Red Blood Cell Count (RBC), White Blood Cell Count (WBC), Platelets Count (PC) and Osmotic Fragility (OF) were determined. Combination of RESV and Vit E significantly increased RBC, WBC PCV and decreased OF compared to the CBZ, RESV and Vit E treated groups respectively. In conclusion, co administration of RESV and Vit E resulted in better protective effect on CBZ induced hematological changes in rats than their respective doses of RESV and Vit E.

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Section: Discussionmentioning

confidence: 99%

Osmotic Fragility and Some Hematological Implications of Chronically Administered Carbamazepine is Attenuated by Resveratrol and Vitamin E Combination

Aliyu

Saleh

et al. 2019

BJSTR

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Effects of dietary supplementation of resveratrol on performance, egg quality, yolk cholesterol and antioxidant enzyme activity of laying hens

Feng

Gong

Zhao

et al. 2017

British Poultry Science

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1. This experiment was conducted to evaluate the effects of dietary supplementation of resveratrol on laying performance, egg quality, egg yolk cholesterol and antioxidant enzyme activities of laying hens. 2. A total of 360 Beijing PINK-1 laying hens (60 weeks old) were randomly distributed among five dietary treatments, each of which included 6 replicates of 12 hens. Dietary treatments were basal diet supplemented with 0 (control), 0.5, 1.0, 2.0 and 4.0 g/kg diet resveratrol. The study lasted for 9 weeks including 1 week of adaptation and 8 weeks of the main experimental period. 3. The results indicated that dietary resveratrol significantly improved feed conversion ratios during 5-8 weeks and 1-8 weeks of the trial. Increasing dietary concentrations of the resveratrol linearly improved Haugh unit and albumen height of eggs. 4. The content of total cholesterol (TC), total triglyceride (TG), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) in serum and cholesterol in yolk was significantly decreased by dietary resveratrol, and there were significant linear correlations between these indexes and resveratrol supplemental levels. 5. Dietary resveratrol supplementation significantly improved serum Glutathione peroxidase (GSH-Px) enzyme activity and decreased serum malondialdehyde (MDA) content in groups with 2.0 and 4.0 g/kg resveratrol as compared to the control, respectively. However, supplementation of resveratrol did not affect the activity of serum superoxide dismutase (SOD). 6. It is concluded that resveratrol supplementation has a positive effect on performance, lipid-related traits and antioxidant activity of laying hens.

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Protective Effect of Resveratrol Co-Administration with Cholesterol Diet on Erythrocyte Osmotic Fragility and Malondialdehyde Concentration in Rabbits

Cited by 2 publications

References 37 publications

Osmotic Fragility and Some Hematological Implications of Chronically Administered Carbamazepine is Attenuated by Resveratrol and Vitamin E Combination

Osmotic Fragility and Some Hematological Implications of Chronically Administered Carbamazepine is Attenuated by Resveratrol and Vitamin E Combination

Effects of dietary supplementation of resveratrol on performance, egg quality, yolk cholesterol and antioxidant enzyme activity of laying hens

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