Protective Effect of Resveratrol against Pentylenetetrazole-Induced Seizures and Its Modulation by an Adenosinergic System

Abstract

The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats. Resveratrol (20, 40, and 80 mg/kg i.p.) administered 20 min prior to convulsive challenge with PTZ (60 mg/kg i.p.) dose dependently reduced the percent incidence of generalized tonic-clonic convulsions. Resveratrol (40 mg/kg) also potentiated the effect of sodium valproate (150 mg/kg) and diazepam (2 mg/kg) against PTZ-induced seizures. Since adenosine, an endogenous anticonvulsant, has been demonstrated to modulate the action of various antiepileptics, experiments were also carried out to determine whether an adenosinergic mechanism is involved in the anticonvulsant action of resveratrol. When a subanticonvulsant dose of adenosine (500 mg/kg) was administered together with resveratrol, a significant reduction in the percent incidence of generalized tonic-clonic convulsions was observed. Moreover, the nonspecific adenosine receptor antagonist theophylline (50 mg/kg i.p.) significantly reversed the resveratrol-induced protection, whereas the specific adenosine A₂ receptor antagonist 3,7-dimethyl-1-propargylxanthine (1 mg/kg i.p.) could not reverse the resveratrol-induced protection. The findings of the present study suggest an antiepileptic potential of resveratrol and that an adenosinergic mechanism may play a role in its anticonvulsant activity.

Resveratrol Attenuates Behavioral Impairments and Reduces Cortical and Hippocampal Loss in a Rat Controlled Cortical Impact Model of Traumatic Brain Injury

“…This compound, also known as 3,5,4 0 -trihydroxystilbene, is a naturallyoccurring phytoalexin that is found in multiple plant sources . In multiple models of neurological injury including stroke (Wang et al, 2002;West et al, 2007), spinal cord injury (Ates et al, 2006;Kaplan et al, 2005;Kiziltepe et al, 2004;Yang and Piao, 2003), epilepsy (Gupta et al, 2002a;2002b;Wu et al, 2009), and Huntington's disease (Parker et al, 2005), resveratrol has demonstrated efficacy in reducing neuropathological and behavioral sequelae. Some studies have also found that traumatic brain injury (TBI) in both adult (Ates et al, 2007) and immature (Sonmez et al, 2007) animals is amenable to treatment with resveratrol, although behavioral protection has not yet been demonstrated in adult models of TBI.…”

Synthesis, Antitubercular and Leishmanicidal Evaluation of Resveratrol Analogues

“…Soc. 2162 neuroprotective, 16,17 free radicals scavenger, and even fighting Alzheimer's disease 18,19 have been also attributed to resveratrol.…”

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“…Recently, additional properties of resveratrol have been documented, such as radical scavenging, antioxidant activity 14,16 , neuroprotection 14,17 , antiviral activity 14,18 , antibacterial activity [19][20][21] , antitubercular activity [22][23][24] . Suitable substituted cisstilbene derivatives are characterized by potent inhibitory activity on COX-2, quite similarly with that observed for a variety of vicinal diarylheterocycles, among which important antiinflammatory drugs, like celecoxib and valdecoxib, are found 25 .…”