Protective effect of quercetin on rat testes against cadmium toxicity by alleviating oxidative stress and autophagy

Wang, Jicang; Zhu, Huali; Wang, Ke; Zhou, Yang; Liu, Zongping

doi:10.1007/s11356-020-08947-2

Cited by 71 publications

(56 citation statements)

References 44 publications

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“…Cadmium exposure markedly decreased the activities of superoxide dismutase and catalase. This is consistent with the most recent finding of others [ [64] , [65] , [66] , [67] ]. Cadmium being a Fenton metal [ 7 , 8 ], may have bound to these enzymes, interacted with the covalent bonds of their amino acids residues and thus abruptly inhibited their activities.…”

Section: Discussionsupporting

confidence: 94%

Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

et al. 2020

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Section: Discussionsupporting

confidence: 94%

Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

et al. 2020

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“…However, mounting evidence has recently proved the efficacy of numerous substances with antioxidant capacity in preventing the Cd‐induced testicular damage (Bashir et al ., 2019; Bhardwaj et al ., 2020a; Wang et al ., 2020). In the present study, co‐incubation with Qcn provides significant protection to the Cd‐induced oxidative stress in testis by inhibiting the lipid peroxidation (decrease in MDA level), and restoring the Cd‐induced reduction in total antioxidant capacity (FRAP activity) with the simultaneous restoration of antioxidant enzymes' (CAT, SOD, GST) activity.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, co‐incubation with Qcn provides significant protection to the Cd‐induced oxidative stress in testis by inhibiting the lipid peroxidation (decrease in MDA level), and restoring the Cd‐induced reduction in total antioxidant capacity (FRAP activity) with the simultaneous restoration of antioxidant enzymes' (CAT, SOD, GST) activity. Our findings are constant with the previous findings that showed that Qcn treatment affords significant protection to the Cd‐induced oxidative stress‐mediated damage through its antioxidant and free radical scavenging capacity (Mao et al ., 2018; Wang et al ., 2018; Wang et al ., 2020). Randomized clinical trials also suggested that medical therapy for infertility with natural antioxidant curcumin or alpha‐lipoic acid supplementation could improve sperm quality parameters by reducing oxidative stress (Alizadeh et al ., 2018; Haghighian et al ., 2015).…”

Section: Discussionmentioning

confidence: 99%

Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro

Bhardwaj

Panchal

2021

Environ and Mol Mutagen

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Cadmium (Cd), an environmental toxic heavy metal, has been reported to cause testicular toxicity, which contributes to the recent decline in male fertility worldwide. Quercetin (Qcn), a major dietary antioxidant, has been shown to have protective effects under various pathological conditions. However, whether Qcn provides protection against Cd‐stimulated testicular toxicity remains obscured. The present study was therefore aimed at investigating the ameliorative effect of Qcn supplementation on Cd‐induced toxicity in the goat testis in vitro in a dose‐(10, 50, and 100 μM) and time‐dependent (4 and 8 h) manner. Different cytotoxicity, genotoxicity, and biochemical analyses have been carried out using appropriate methods. Cytotoxicity in testicular cells induced by Cd treatment was apparently mitigated by Qcn treatment, evidenced by decreased apoptotic attributes or frequency in Qcn plus Cd‐treated groups compared to the only Cd‐treated groups. Qcn treatment provides substantial protection to the Cd‐triggered aggression in oxidative (increased MDA levels) and total antioxidant capacity (reduced FRAP activity) in testicular tissue, indicating the anti‐oxidative function of Qcn against Cd exposure. Moreover, Cd‐induced decline in antioxidant status (CAT, SOD, and GST activity) was markedly restored by Qcn supplementation in testicular tissue. In conclusion, this study shows that Qcn treatment significantly attenuated the Cd‐evoked testicular damage, suggesting its beneficial potential in preventing or at least in managing the gonadotoxicity in males induced by steadily increasing Cd contamination in the environment.

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“…The weight of the testis was then measured in grams using a digital analytical balance (Sartorius CP 324S), sensitive to weight increment of 0.0001 gram. Relative Tissue Body Weight Index (RTBWI) was calculated to get standardize the weight of the testis over rats of different sizes, using the following formula 16 .…”

Section: Methodsmentioning

confidence: 99%

Prophylactic Effect of Coenzyme Q10 on Gross Parameters of Rat Testis Exposed to Mosquito Coil Smoke Inhalation

Atta

Qamar

Iram

et al. 2021

PAFMJ

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Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy Army Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, from Jan 2020 to Dec 2020. Methodology: This study was carried out among 30 male Sprague Dawley rats, distributed into three groups as 10 rats/group; group A served as control group, rats in group B were exposed to allethrin-based mosquito coil smoke 4hours/day for 12 weeks. Rats in group C were administered Coenzyme Q10 (10 mg/kg/day) via oral gavage for 12 weeks along with mosquito coil smoke exposure. At the end of study, gross parameters of body weight gain, testicular weight and volume, and relative tissue body weight index of testis were compared among groups. Results: Rats exposed to mosquito coil smoke alone showed significantly less weight gain (p<0.001)), testicular weight (p<0.001), volume (p<0.001), and relative tissue body weight index (p<0.001) as compared to control group. Rats administered Coenzyme Q10 along with mosquito coil smoke exposure exhibited significantly higher weight gain (p<0.001), testicular weight (p<0.001), volume (p<0.001) and relative tissue body weight index (p<0.001) as compared to rats exposed to mosquito coil smoke alone. Conclusion: Long-term inhalation of allethrin-based mosquito coil smoke caused testicular atrophy among rats, as evident by reduced testicular weight, volume and relative tissue body weight index. Whereas, prophylactic oral administration of Coenzyme......................

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Protective effect of quercetin on rat testes against cadmium toxicity by alleviating oxidative stress and autophagy

Cited by 71 publications

References 44 publications

Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro

Prophylactic Effect of Coenzyme Q10 on Gross Parameters of Rat Testis Exposed to Mosquito Coil Smoke Inhalation

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