Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy Army Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, from Jan 2020 to Dec 2020. Methodology: This study was carried out among 30 male Sprague Dawley rats, distributed into three groups as 10 rats/group; group A served as control group, rats in group B were exposed to allethrin-based mosquito coil smoke 4hours/day for 12 weeks. Rats in group C were administered Coenzyme Q10 (10 mg/kg/day) via oral gavage for 12 weeks along with mosquito coil smoke exposure. At the end of study, gross parameters of body weight gain, testicular weight and volume, and relative tissue body weight index of testis were compared among groups. Results: Rats exposed to mosquito coil smoke alone showed significantly less weight gain (p<0.001)), testicular weight (p<0.001), volume (p<0.001), and relative tissue body weight index (p<0.001) as compared to control group. Rats administered Coenzyme Q10 along with mosquito coil smoke exposure exhibited significantly higher weight gain (p<0.001), testicular weight (p<0.001), volume (p<0.001) and relative tissue body weight index (p<0.001) as compared to rats exposed to mosquito coil smoke alone. Conclusion: Long-term inhalation of allethrin-based mosquito coil smoke caused testicular atrophy among rats, as evident by reduced testicular weight, volume and relative tissue body weight index. Whereas, prophylactic oral administration of Coenzyme......................
Objective: To study the effects of injection botox in masseter muscle on the morphometric measurement of underlying mandible and total body weight change in Sprague Dawley rats.Study Design: Laboratory-based experimental study. Place and Duration of Study: Anatomy Department, Army Medical College, Rawalpindi, with collaboration with Military Hospital, Rawalpindi and National Institute of Health (NIH), Islamabad, from Jun to Aug 2020. Methodology: Female sprague dawley rats, 10 weeks of age, weighing 200-250 gm were selected. They were housed in separate cages in animal house of NIH under standard laboratory conditions and received regular diet and water ad libitum. Animals were divided into three groups. Group-A served as control while group B and C were experimental groups. Group-B was sham injected whilst group-C was injected by injection botox in left masseter muscle. Initial and final weights of the rats were recorded. All the rats were sacrificed after completion of experimental period. Weight of left mandibles was recorded. All the specimens of mandibles were cleaned and the mandibular length, condylar head length and width were measured by Vernier caliper. Result: Total 30 sprague dawley rats were included in the study. Injection botox decreased the morphometric measurements of the mandible in experimental group-C when compared with control group-A and sham group-B with the statistically significant result (p<0.001).
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