Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice

Protective effects of Quercetin and chronic moderate exercise (training) against oxidative stress in the liver tissue of streptozotocin-induced diabetic rats

“…Our results are consistent with recent research that revealed the hypoglycemic effect of Quercetin in animal models of type 1 diabetes (1,2,19,22). Quercetin is a polyphenol of the flavonol group known for its many beneficial effects on the body.…”

“…The free radicals lead to glycation reactions and oxidative modification of lipids, protein modification, and DNA damage. Our results are inkeeping with other recent studies that state the fact that diabetes mellitus increases oxidative stress in the liver in an animal model system (1,30). The present study found a significant increase in the levels of MDA, which is an end product of lipoperoxidation, and PC, produced by protein oxidation, associating with lowering antioxidant activities in the liver which demonstrates the presence of oxidative stress in STZinduced diabetic rats, at this level.…”

“…Quercetin is a polyphenol of the flavonol group known for its many beneficial effects on the body. The Quercetin mechanism that lowers blood sugar was explained by: its α-glycosidase inhibitory activity in vitro; the increase of the hexokinase activity; the decrease in the glucose-6-phosphatase and fructo-bisphosphatase activities; the increased expression of GLUT 4 (insulin-dependent glucose transporter) via mRNA expression and translocation to the plasma membrane (1).…”

“…A highly promising candidate for the prevention of adverse effects of oxidative stress in DM is Quercetin (3,4,5,7,3,4-penta-hydroxyflavone), which is one of the most abundant flavonoids in the human diet, as it is present in fruits and vegetables such as onions, citrus fruits, berries, red grapes, red wine, broccoli, bark roots, flowers, and tea (6). Quercetin has protective effects against beta-cell damage and it's capable of decreasing blood glucose levels in diabetes (1,2). Recent studies demonstrated that Quercetin has strong antioxidant and protective effects against oxidative stress in streptozotocin (STZ)-induced diabetic rats, protecting various tissues and organs (4,10,19) such as the liver (11), pancreatic gland, kidneys (2) and testis (22).…”

Protective Effects of Polysaccharides from Radix Astragali Against Alloxan-induced Oxidative Stress in Diabetic Mice

“…While on the one hand hyperglycemia engenders free radicals, on the other hand it also impairs the endogenous antioxidant defense system in many ways during diabetes [4]. Oxidative stress can damage several biomolecules like proteins, lipids and DNA, thereby leading to the inactivation of enzymes affecting DNA integrity and cellular membrane composition [16]. Thus, the ideal anti-diabetic drug should combine both hypoglycemic and antioxidant properties.…”