Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice

Yang, Bo; Zhang, Xiangyu; Guan, Shengwen; Hua, Zichun

doi:10.3390/molecules200712250

Cited by 92 publications

(87 citation statements)

References 33 publications

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“…Also, CCl4 alter the antioxidant profile of the liver by reacting with sulfhydryl groups of glutathione (GSH) and thiols group of protein, including the antioxidant enzymes as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione transferase (GST) (Knockaert et al, 2012;Yang et al, 2015).…”

Section: Epa Iris 2010)mentioning

confidence: 99%

Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Zahran¹,

SA²,

El-Moneim³

et al. 2018

JEBAS

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Present study has been carried out evaluate prophylactic effect of Camel milk on physiological and biochemical changes in CCl4-intoxicated rats. A total of 36 male albino rats were randomly divided into 6 groups viz. control group (G1), silymarin (SM) group (G2), camel milk (CM) group (G3), CCl4-intoxicated group (G4), silymarin prophylactic group (G5) and camel milk prophylactic group (G6). Each group has six rats. After completion of the study (8 wks), blood samples were collected and hematological parameters, liver contents of glutathione (GSH), malondialdhyde (MDA) , superoxide dismutaseactivity (SOD), serum urea, uric acid, creatinine, testosterone, estradiol were measured. The results of this study revealed that CCl4 toxicity significantly reduced Hb level, RBCs count and PCV, whereas it significantly increased the WBCs count with respect to normal control. Intoxication of CCl4 in G4 rats led to microcytic hypochromic anaemia, increased erythrocyte fragility and, leukocytosis was accompanied neutrophils increases and a decrease in lymphocyte counts. Also, CCl4 produced significant increase in serum urea, uric acid, creatinine and estradiol level and decrease in circulating testosterone level compared with normal rats. Pre-treatment with CM and SM brought significant restoration in hematological, renal function parameters and sexual hormones disturbance. Moreover, lipid peroxidation and oxidative stress were obviously noted in CCl4 intoxicated (G4) organism where a

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Section: Epa Iris 2010)mentioning

confidence: 99%

Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Zahran¹,

SA²,

El-Moneim³

et al. 2018

JEBAS

View full text Add to dashboard Cite

show abstract

“…Later, the damage is through increased expression of various pro-inflammatory mediators such as tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), interleukin-1 (IL-1), cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB). 15,16,17 When the liver cells are injured, its enzymes spill into the blood, causing elevated levels of ALT, AST, ALP, γ-glutamyl transpeptidase, sorbitol dehydrogenase, glutamate dehydrogenase and lactate dehydrogenase. Bilirubin, the endogenous product derived from the degradation of haemoglobin, builds up in the blood and extracellular fluid as its excretion is impaired.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

et al. 2017

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Background: In absence of reliable hepatoprotective drug in modern medicine, the traditional herbal medicines have been emphasized. Present study was designed to assess hepatoprotective effect of aqueous extract of Melothria perpusilla (AEMP) against carbon tetrachloride (CCl4) induced liver injury.Methods: Five groups of animals with 6 rats in each were treated for 7 days. Group I received 1% gum acacia in distilled water (1 ml/200 g p.o.) daily. Group II, III, IV and V received CCl4 in liquid paraffin (1 ml/kg s.c.) on day 2, 4 and 6. Group III, IV and V were treated respectively with silymarin (100 mg/kg p.o.), AEMP- 200 and 400 mg/kg p.o. daily. On day 8, liver injury was assessed by measuring serum ALT, AST, ALP and bilirubin.Results: ALT, AST, ALP and bilirubin were significantly reduced in groups receiving both CCl4 and AEMP when compared with CCl4 treated group.Conclusions: AEMP produced hepatoprotective effect against CCl4 induced liver injury.

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“…MDA is one of the main lipid peroxidation products, which was assessed as an indicator of lipid peroxidation in oxidative liver damage [63]. Saad et al [62] have reported a close relationship between lipid peroxidation and fibrogenesis in CCl 4 treated rats.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Carbon Tetrachloride and Ethanol-Induced Hepatic Fibrosis in Rats by Calligonum Comosum Shoot Extract

Mousa¹,

Hassan²,

El-Sammad³

2017

Asian J Pharm Clin Res

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Objective: This study was designed to evaluate the hepatoprotective and antioxidant effects of methanolic extract of Calligonum comosum (C. comosum) shoots on the hepatic fibrosis induced by carbon tetrachloride and ethanol (CCl 4 /ethanol) in rats.Methods: A liver fibrosis was induced in Sprague Dawley rats by oral administration of CCl 4 (1 ml/kg body weight, twice weekly for 10 weeks) along with ethanol (10% in drinking water 1 week before CCl 4 administration and throughout the experiment). Rats were pretreated with C. comosum extract (daily, orally at a dose of 50 mg/kg body weight 1 week before CCl 4 administration). At the end of the experiment, serum, and liver samples were subjected to biochemical investigations. In addition, liver and kidney tissues were evaluated for histopathological changes.Results: C. comosum extract pretreatment significantly reduced CCl 4 -induced elevation in serum levels of aspartate aminotransaminase, alanine aminotransaminase, alkaline phosphatase, total bilirubin, urea, creatinine, and significantly elevated serum contents of total protein and albumin, as well as an improvement in hepatic protein content, albumin/globulin ratio, body weight and relative liver and kidney weights. C. comosum extract also significantly increased the hepatic levels of glucose-6-phosphatase, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, and glutathione with significant decrease in the contents of malondialdehyde and protein carbonyl. In addition, downregulation in expression of the fibrotic marker matrix metalloproteinase-2 was observed. C. comosum extract also ameliorated histopathological changes of CCl 4 /ethanol group which further evidenced the biochemical findings. Conclusion:Our results confirmed that the methanolic extract of C. comosum shoots effectively protect against CCl 4 /ethanol-induced liver fibrosis, through its antioxidant property.

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Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice

Cited by 92 publications

References 33 publications

Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

Attenuation of Carbon Tetrachloride and Ethanol-Induced Hepatic Fibrosis in Rats by Calligonum Comosum Shoot Extract

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