Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Zahran, Faten; SA, Gabr; El-Moneim, Abd El-Moneim Eid Abd; MN, Sharoud; WF, Hassanin; NM, Mesalam

doi:10.18006/2018.6(1).211.219

Cited by 4 publications

(2 citation statements)

References 43 publications

(46 reference statements)

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“…These findings were in agreement with Zahran et al, (2018) who revealed that CCl4 injected i/p into the experimental rats at a dose of 1 ml/kg b.w, once daily, 3 times weekly for four weeks to induce toxicity significantly reduced Hb level, RBCs count and PCV. The intoxication of CCl4 in rats led to microcytic hypochromic anemia and increased erythrocyte fragility.…”

Section: Discussionsupporting

confidence: 92%

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Comparative Hematological and Biochemical Studies on the Effect of Some Hepatoprotective Agents in Rats

Kilany

Khalil

Saied

et al. 2020

Egyptian Academic Journal of Biological Sciences, B. Zoology

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This work was conducted to investigate the hepato-protective effect of chamomile extract, grape seed extract and Silymarin against carbon tetrachloride-induced hepatic toxicity in rats. A total of 80 normal male albino rats, were divided into 8 groups, the first group (group I): rats served as the control group and received commercial balanced diet all over the experimental period (3 weeks), group II: chamomile orally treated group (200mg/kg,) for the whole experimental period, group III: grape seed orally treated group (100mg/kg), for the whole experimental period, group IV: silymarin orally treated group (100mg/kg) for the whole experimental period, group V: served as hepatotoxicated group, treated with an intraperitoneal injection of 2mg /kg b. w. of carbon tetrachloride(CCl 4) dissolved into corn oil 1:1 at 11 and 12 days of an experiment to induce hepato-toxicity and groupVI: chamomile orally pretreated group (200mg/kg) for the whole experimental period with i/p injection of CCl 4 in days 11 and 12 of the experiment, group VII: grape seed orally pretreated group (100mg/kg) for the whole experimental period, with i/p injection of CCl 4 in days 11 and 12 of the experiment and group VIII: silymarin orally pretreated group (100mg/kg) for the whole experimental period, with i/p injection of CCl 4 in days 11 and 12 of the experiment. Objective: The present study was carried out to investigate the effect of oral administration of ethanol extract of chamomile capitula extract, grape seed and silymarin for 3 weeks on hepatotoxicity induced to rats by carbon tetrachloride (CCl 4). These effects were explored by measuring erythrogram and serum levels of liver enzymes; aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP); albumin, globulin, total protein, cholesterol, bilirubin, albumin. Results: The results showed that the oral administration of chamomile extract, a grape seed extract, and silymarin to hepato-injured rats for 21 days improved anemia and significantly decreased the elevated serum levels of liver enzymes (AST, ALT, and ALP), total bilirubin and increased serum total protein, albumin, when compared to the corresponding control, positive groups. Conclusion: The results suggest that the chamomile extract, grape seed extract, and silymarin induce potent hepato-protective effects in CCl 4 induced hepato-injury in rats. This study recommends that intake of chamomile and grape seed extracts as an herbal may be beneficial for patients who suffer from liver diseases.

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Section: Discussionsupporting

confidence: 92%

“…Similar results were obtained by Zahran et al, (2018) showed that CCl4 toxicity significantly reduced Hb level, RBCs count and PCV with respect to normal control. The intoxication of CCl4 rats led to microcytic hypochromic anaemia, increased erythrocyte fragility.…”

Section: Discussionsupporting

confidence: 87%

Comparative Hematological and Biochemical Studies on the Effect of Some Hepatoprotective Agents in Rats

Kilany

Khalil

Saied

et al. 2020

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Comparative Protective Effects of Spirulina and Spirulina Supplemented with Thiamineagainst Sub-acute Carbon Tetrachloride Toxicity in Rats

El-Bialy

El-Boraey

Hamouda

et al. 2019

Biomed. Pharmacol. J.

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Carbon tetrachloride (CCl4) is used extensively as an industrial solvent and considered the best-characterized experimental animal model of xenobiotic-induced hepatic toxicity via reactive oxygen species (ROS) generation. This study was designed to evaluate the protective effects of Spirulina platensis (SP) versus Spirulina platensis supplemented with thiamine (SPt) against subacute CCl4 toxicity in rats. Rats were divided into six equal groups; Control vehicle (0.5 ml/rat 1:1 olive oil in water), SP (800 mg/kg b.wt.), SPt (800 mg/kg b.wt.), CCl4 (1ml/kg b.wt.), SP + CCl4 and SPt + CCl4. All treatments were orally and daily for a month except CCl4 was given three times weekly. CCl4 caused significant reduction in body weight gain, haemoglobin content and haematocrit percentage accompanied by leukocytosis, granulocytosis, monocytosis and lymphocytopenia. Moreover, there were significant increase in the levels of serum ALT, AST; total, direct and indirect bilirubin; urea and creatinine of CCL4- intoxicated rats. CCL4- induced significant increase of malondialdehyde levels with significant reduction of catalase activity in liver and kidney. In addition, hepatic and renal various histopathological alterations were recorded. SP and SPt ameliorated almost these changes while they couldn’t reverse the reduction of body weight gains and red blood indices. The more potent effects on measured parameters were elucidated by SPt. In conclusion SP and SPt could be used as natural antioxidant supplements to counteract the CCl4 adverse effects.

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Nuclear Energy in Israel: A Concept Study

Kroupenev¹,

Alexenberg

Cornblit³

et al. 2008

SSRN Journal

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Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Cited by 4 publications

References 43 publications

Comparative Hematological and Biochemical Studies on the Effect of Some Hepatoprotective Agents in Rats

Comparative Hematological and Biochemical Studies on the Effect of Some Hepatoprotective Agents in Rats

Comparative Protective Effects of Spirulina and Spirulina Supplemented with Thiamineagainst Sub-acute Carbon Tetrachloride Toxicity in Rats

Nuclear Energy in Israel: A Concept Study

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