Protective effect of probiotic bacteria against cadmium-induced genotoxicity in rat hepatocytes in vivo and in vitro

Jama, M Adel; Mitić-Ćulafić, Dragana; Kolarević, Stoimir; Đurašević, Siniša; Knežević-Vukčević, Jelena

doi:10.2298/abs1203197j

Cited by 37 publications

(13 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The protective effect of LAB against the toxicity of Cd has also been demonstrated. Strains of L. acidophilus and B. longum (5 × 10 8 CFU/g of food) significantly reduced Cd-induced genotoxicity (around 20%) in mice treated for 5 weeks with CdCl2 (70 mg/L in drinking water) (Jama et al, 2012). Zhai et al (2014) also showed that L. plantarum CCFM8610 (10 9 CFU in 0.5 mL of skim milk once daily via gavage) reduced oxidative stress caused by exposure to Cd (10 mg/mL in drinking water during 8 weeks).…”

Section: Metals and Metalloidsmentioning

confidence: 99%

Use of lactic acid bacteria and yeasts to reduce exposure to chemical food contaminants and toxicity

Chiocchetti

Jadán-Piedra

Monedero

et al. 2018

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

Chemical contaminants that are present in food pose a health problem and their levels are controlled by national and international food safety organizations. Despite increasing regulation, foods that exceed legal limits reach the market. In Europe, the number of notifications of chemical contamination due to pesticide residues, mycotoxins and metals is particularly high. Moreover, in many parts of the world, drinking water contains high levels of chemical contaminants owing to geogenic or anthropogenic causes. Elimination of chemical contaminants from water and especially from food is quite complex. Drastic treatments are usually required, which can modify the food matrix or involve changes in the forms of cultivation and production of the food products. These modifications often make these treatments unfeasible. In recent years, efforts have been made to develop strategies based on the use of components of natural origin to reduce the quantity of contaminants in foods and drinking water, and to reduce the quantity that reaches the bloodstream after ingestion, and thus, their toxicity. This review provides a summary of the existing literature on strategies based on the use of lactic acid bacteria or yeasts belonging to the genus Saccharomyces that are employed in food industry or for dietary purposes.

show abstract

Section: Metals and Metalloidsmentioning

confidence: 99%

Use of lactic acid bacteria and yeasts to reduce exposure to chemical food contaminants and toxicity

Chiocchetti

Jadán-Piedra

Monedero

et al. 2018

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

show abstract

“…Several recent reports confirmed that other probiotics may also be protective against heavy metal toxicity. A mixture of L. rhamnosus Rosell-11, L. acidophilus Rosell-52 and B. longum Rosell-175 significantly reduced Cd-induced genotoxicity both in vitro using liver tissue culture and in rats [ 122 ]. Another study investigated the potential of L. rhamnosus GR-1 supplemented yogurt to lower heavy metal levels in at-risk populations of pregnant women and in children in Tanzania [ 123 ].…”

Section: Probiotics As Functional Food Supplementsmentioning

confidence: 99%

Dietary Strategies for the Treatment of Cadmium and Lead Toxicity

2015

View full text Add to dashboard Cite

Cadmium (Cd) and lead (Pb) are toxic heavy metals that cause adverse health effects in humans and animals. Chelation therapy, the conventional treatment for heavy metal toxicity, is reported to have a number of safety and efficacy issues. Recent studies have shown that dietary supplements play important roles in protecting against Cd and Pb toxicity. This paper reviews the evidence for protective effects of essential metals, vitamins, edible plants, phytochemicals, probiotics and other dietary supplements against Cd and Pb toxicity and describes the proposed possible mechanisms. Based on these findings, dietary strategies are recommended for people at risk of Cd and Pb exposure. The application of these strategies is advantageous for both the prevention and alleviation of Cd and Pb toxicity, as such supplements can be added easily and affordably to the daily diet and are expected to have very few side effects compared to the chelation therapy.

show abstract

“…Feeding lyophilized probiotic mixture of bacteria (Lactobacillus rhamnosus, L. acidophilus and Bifidobacterium longum) at 5 × 108 cfu/g of food for 5 weeks reduced cadmium induced genotoxicity by 20% in rats [43]. The same study also found that much higher reduction (48%) of genotoxicity by probiotic mixture was observed in in vitro hepatocytes.…”

Section: Physical Binding/inactivation Of Mutagenic/carcinogenic/genomentioning

confidence: 72%

Chemopreventive Potential of Probiotics and Prebiotics

Sunkata¹,

Herring²,

Walker³

et al. 2014

FNS

View full text Add to dashboard Cite

Utilization of probiotics and prebiotics in food products and in the diet supplemental form continues to gain interest because of their health benefits. Cancer is the leading cause of death and strategies for chemoprevention are important to reduce mortality and morbidity. Probiotics are gaining attention to use as preventive agents. Efficacy of their use as chemopreventive agents was established through research. This review focused on the mechanisms of prebiotics and probiotics action against cancer. Benefits of probiotics against cancer are attributed to competitive exclusion of pathogenic bacteria, direct physical binding to carcinogens, altering intestinal environment to modulate the production enzymes, antioxidant activity and immune modulation. Prebiotics are indigestible food components that could promote the growth of probiotics. Chemopreventive properties of prebiotics are due to their production of short chain fatty acids and enhancing the immunity of the host. Anticarcinogenic properties of pre-and probiotics result from a combination of events rather from a single event.

show abstract

Protective effect of probiotic bacteria against cadmium-induced genotoxicity in rat hepatocytes in vivo and in vitro

Cited by 37 publications

References 33 publications

Use of lactic acid bacteria and yeasts to reduce exposure to chemical food contaminants and toxicity

Use of lactic acid bacteria and yeasts to reduce exposure to chemical food contaminants and toxicity

Dietary Strategies for the Treatment of Cadmium and Lead Toxicity

Chemopreventive Potential of Probiotics and Prebiotics

Contact Info

Product

Resources

About