Chemopreventive Potential of Probiotics and Prebiotics

Abstract

Utilization of probiotics and prebiotics in food products and in the diet supplemental form continues to gain interest because of their health benefits. Cancer is the leading cause of death and strategies for chemoprevention are important to reduce mortality and morbidity. Probiotics are gaining attention to use as preventive agents. Efficacy of their use as chemopreventive agents was established through research. This review focused on the mechanisms of prebiotics and probiotics action against cancer. Benefits of probiotics against cancer are attributed to competitive exclusion of pathogenic bacteria, direct physical binding to carcinogens, altering intestinal environment to modulate the production enzymes, antioxidant activity and immune modulation. Prebiotics are indigestible food components that could promote the growth of probiotics. Chemopreventive properties of prebiotics are due to their production of short chain fatty acids and enhancing the immunity of the host. Anticarcinogenic properties of pre-and probiotics result from a combination of events rather from a single event.

Adherence of probiotic bacteria to human colon epithelial cells and inhibitory effect against enteric pathogens – In vitro study

“…Milk and dairy products thus are very good forms of administration for probiotics through the diet (S anchez et al 2009). The health benefits of probiotics were reported in many studies (Chakraborti 2011;Duncan and Flint 2013;Sunkata et al 2014;Amara and Shibl 2015;Pandey et al 2015). One of the principles for a prospective probiotic strain is the ability to adhere to mucosal surfaces of the gastrointestinal tract.…”

“…The health benefits of probiotics were reported in many studies (Chakraborti ; Duncan and Flint ; Sunkata et al . ; Amara and Shibl ; Pandey et al . ).…”

Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation

“…Carcinogens represent the substances inducing cancer in humans. Increased consumption of processed red meat and low consumption of vegetables and fruits might provoke carcinogenesis in humans through food intake (Sunkata et al, 2014). Notable carcinogens reported comprising tryptophanase, acetaldehyde,…”

The Role of Curcumin in Gastric Carcinoma by Modulating the Immune System and its SAR

“…Low rates of survival and the vast majority of cases of stomach cancer are fatal 2 . Due to their chemo-prevention abilities, natural products such as green tea, resveratrol 3 , vitamins, and functional meals like probiotics and prebiotics may be helpful 4 . CUR, a natural cancer-preventing drug, has drawn more interest since it can stop tumour growth.…”