Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance

Chen, Tong; Gao, Jin; Xiang, Pengjun; Chen, Yongde; Ji, Jing; Xie, Peng; Wu, Hui; Xiao, Wei; Wei, Yanyan; Wang, Shumin; Li, Lan; Ji, Hui; Yan, Tianhua

doi:10.1016/j.intimp.2015.04.001

Cited by 89 publications

(44 citation statements)

References 34 publications

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“…In response to NDEA stimulation, cytoplasmic transaminase including ALT and AST is released and enters circulation. Both ALT and AST serve as reliable diagnostic indicators of liver injury [19]. The data displayed that the activities of transaminases significantly increased, which confirmed the successful building of NDEA-induced HCC model.…”

Section: Discussionmentioning

confidence: 80%

Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO‐1/NF‐κB Pathway

Zheng

Peng

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The purpose of the present study was to evaluate the pharmacological effects of Portulaca oleracea L. (Purslane) (PL) on N-nitrosodiethylamine- (NDEA-) induced hepatocellular carcinomas (HCC) and explore its potential mechanism. Mice were randomly assigned to four groups: control group, NDEA group, NDEA + Purslane (100 mg/kg) group, and NDEA + Purslane (200 mg/kg) group. The animal of each group was given NDEA (100 ppm) in drinking water. 1 h later, Purslane dissolved in PBS was intragastrically administered for continuous seven days. The results showed that Purslane reduced the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in liver and serum. Purslane also reduced the contents of interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), and methane dicarboxylic aldehyde (MDA) and restored the activity of superoxygen dehydrogenises (SOD) in serum. Purslane could obviously attenuate the hepatic pathological alteration. Furthermore, treatment with Purslane effectively inhibited the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), mammalian target of rapamycin (mTOR), nuclear factor-kappa B (NF-κB), and inhibitor of NF-κBα (IκBα) and upregulated the expressions of NF-E2-related factor 2 (Nrf2) and heme oxygenase- (HO-) 1. In conclusion, our research suggested that Purslane exhibited protective effects on NDEA-induced hepatocellular carcinomas by anti-inflammatory and antioxidative properties via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway.

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Section: Discussionmentioning

confidence: 80%

Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO‐1/NF‐κB Pathway

Zheng

Peng

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Western blot was performed as described previously [22]. The blots were incubated overnight with primary rabbit anti-NF-κB (p65) antibody (1:1000, Cell Signaling Technology), rabbit anti-IκBα antibody (1:1000, Cell Signaling Technology), anti-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) antibody(1:1000, Cell Signaling Technology), rabbit anti-lamin B1 antibody (1:1000, Abcam), rabbit anti-voltage-dependent anion channel 1(VDAC1) antibody (1:5000, Abcam), rabbit anti-cytochrome C antibody (1:5000, Abcam) and rabbit anti-PARP-1 antibody (1:5000, Abcam).…”

Section: Gel Electrophoresis and Western Blotmentioning

confidence: 99%

Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition

Wang

Shi

Feng

et al. 2016

International Immunopharmacology

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“…The fresh roots of P. grandiflorum have been eaten as pickles for preventing obesity in China and Korea [15]. As a major and the most potent pharmacological constituent of Platycodi radix, Platycodin D (PLD) has been shown to exhibit a variety of pharmacological activities, such as antidiabetic [16], anti-inflammatory [17], anticancer [18], antinociceptive [19] and immunomodulatory [20]. Despite the several known effects of PLD, few work focused on ALI prevention promoted by this compound has been reported to date.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro

Tao

Wang

et al. 2015

International Immunopharmacology

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Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance

Cited by 89 publications

References 34 publications

Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO‐1/NF‐κB Pathway

Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO‐1/NF‐κB Pathway

Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition

Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro

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