2011
DOI: 10.1016/s2222-1808(11)60002-9
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Protective effect of pineapple (Ananas cosmosus) peel extract on alcohol–induced oxidative stress in brain tissues of male albino rats

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Cited by 49 publications
(26 citation statements)
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“…Its hydrophilic and lipophilic nature also aids in its free radical scavenging and antioxidant actions. Its lipophilic nature enhances the easiness at which it crosses the morphophysiological barriers, such as the bloodbrain barrier, and then effectively enters the cells and subcellular compartments [47,48] . It distributes in all cell compartments, being especially high in the nucleus and mitochondria [49,50] .…”
Section: Discussionmentioning
confidence: 99%
“…Its hydrophilic and lipophilic nature also aids in its free radical scavenging and antioxidant actions. Its lipophilic nature enhances the easiness at which it crosses the morphophysiological barriers, such as the bloodbrain barrier, and then effectively enters the cells and subcellular compartments [47,48] . It distributes in all cell compartments, being especially high in the nucleus and mitochondria [49,50] .…”
Section: Discussionmentioning
confidence: 99%
“…The citric acid content in the sperm suspension of the seed extract fed rats revealed a significant decrement indicating the reduced oxidative metabolism. Citric acid level in the sperm suspension forms the index towards the level of oxidative metabolism of the spermatozoa as well as the reproductive tissue [26][27][28][29][30][31][32][33][34][35][36][37] . The activity level of the enzyme iso-citrate dehydrogenase recorded significant depletion in the extract fed rats when compared with that of the control indicating the deranged oxidative potential in the sperm suspension.…”
Section: Discussionmentioning
confidence: 99%
“…The result is owing to a mechanism related to phagocytosis by macrophages. The process of phagocytosis by macrophages includes opsonisation of the foreign particulate matter with antibodies and complement C3b leading to more rapid clearance of foreign particulate matter from the blood [17][18][19][20][21] . Alcohol extract although produced dose dependently increase in phagocytic index but no significant value was obtained with selected doses.…”
Section: Discussionmentioning
confidence: 99%
“…Male Balb/C mice (Mus musculus) [8][9][10] weeks old and weighing [18][19][20][21][22] g, in groups of six each were used for the study. The animals were housed under standard laboratory conditions with a temperature of (23暲1) 曟 , relative humidity of (55暲10)%, 12/12 h light-dark cycles and fed with a standard pellet diet (Lipton India Ltd.) and water was given ad libitum.…”
Section: Animalsmentioning
confidence: 99%